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Protein Overview: Dscam-PAC

General Information:
Name(s) found: Dscam-PAC / FBpp0110343 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2031 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVNQF YGADILMEYV IRGNAAVLKC SIPSFVADFV RVESWIDEEG 180
  181 TELRPSENYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGSVAPKVD MHDKMDFTIR SSNRSLNLFC KAQGFPMPAF RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMAPPK IAPFDFGQSA SSFEDSVSVN CLVTSGDLPI DIEWLFGGEP 660
  661 INFATGIAIL RGGKRTSLLT IDSVHAGHAG NYTCKAKNQA SSSEYSAALI VNVPPRWILE 720
  721 PTDKAFAQGS DAKVECKADG FPKPQVTWKK AVGDTPGEYK DLKKSDNIRV EEGTLHVDNI 780
  781 QKTNEGYYLC EAINGIGSGL SAVIMISVQA PPEFTEKLRN QTARRGEPAV LQCEAKGEKP 840
  841 IGILWNMNNM RLDPKNDNRY TIREEILSTG VMSSLSIKRT ERSDSALFTC VATNAFGSDD 900
  901 ASINMIVQEV PEMPYALKVL DKSGRSVQLS WAQPYDGNSP LDRYIIEFKR SRASWSEIDR 960
  961 VIVPGHTTEA QVQKLSPATT YNIRIVAENA IGTSQSSEAV TIITAEEAPS GKPQNIKVEP1020
 1021 VNQTTMRVTW KPPPRTEWNG EILGYYVGYK LSNTNSSYVF ETINFITEEG KEHNLELQNL1080
 1081 RVYTQYSVVI QAFNKIGAGP LSEEEKQFTA EGTPSQPPSD TACTTLTSQT IRVGWVSPPL1140
 1141 ESANGVIKTY KVVYAPSDEW YDETKRHYKK TASSDTVLHG LKKYTNYTMQ VLATTAGGDG1200
 1201 VRSVPIHCQT EPDVPEAPTD VKALVMGNAA ILVSWRPPAQ PNGIITQYTV YSKAEGAETE1260
 1261 TKTQKVPHYQ MSFEATELEK NKPYEFWVTA STTIGEGQQS KSIVAMPSDQ VPAKIASFDD1320
 1321 TFTATFKEDA KMPCLAVGAP QPEITWKIKG VEFSANDRMR VLPDGSLLIK SVNRQDAGDY1380
 1381 SCHAENSIAK DSITHKLIVL APPQSPHVTL SATTTDALTV KLKPHEGDTA PLHGYTLHYK1440
 1441 PEFGEWETSE VSVDSQKHNI EGLLCGSRYQ VYATGFNNIG AGEASDILNT RTKGQKPKLP1500
 1501 EKPRFIEVSS NSVSLHFKAW KDGGCPMSHF VVESKKRDQI EWNQISNNVK PDNNYVVLDL1560
 1561 EPATWYNLRI TAHNSAGFTV AEYDFATLTV TGGTIAPLDD GSGHGNVHTR IRLPAWMPEW1620
 1621 LDLNFMVPLI ATVVVVAVGI CVVCVALSRR RADDMRGGQK DVYYDVVYNQ TMGPGATLDK1680
 1681 RRPDLRDELG YIAPPNRKLP PVPGSNYNTC DRIKRGRGGL RSNHSTWDPR RNPNLYEELK1740
 1741 APPVPMHGNH YGHAHGNAEC HYRHPGMEDE ICPYATFHLL GFREEMDPTK AMNFQTFPHQ1800
 1801 NGHAGPVPGH AGTMLPPGHP GHVHSRSGSQ SMPRANRYQR KNSQGGQSSI YTPAPEYDDP1860
 1861 ANCAEEDQYR RYTRVNSQGG SLYSGPGPEY DDPANCAPEE DQYGSQYGGP YGQPYDHYGS1920
 1921 RGSMGRRSIG SARNPGNGSP EPPPPPPRNH DMSNSSFNDS KESNEISEAE CDRDHGPRGN1980
 1981 YGAVKRSPQP KDQRTTEEMR KLIERNETGP KQLQLQQANG AGFTAYDTMA V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..253] PSI-BLAST 80.69897 No description for 2v5sA was found.
    2 View Details [254..895] PSI-BLAST 60.09691 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    3 View Details [896..1371] PSI-BLAST 30.39794 No description for 2v5yA was found.
    4 View Details [1372..1659] PSI-BLAST 22.30103 Fibronectin, different Fn3 modules
    5 View Details [1660..1836] deduced N/A No confident structure predictions are available.
    6 View Details [1837..1937] MSA 2.116992 View MSA. No confident structure predictions are available.
    7 View Details [1938..2031] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • telethonin binding
    		•  5.81747667416248 bayes_pls_golite062009
  • structural constituent of muscle
    		•  5.71979489668015 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.81256300373074 bayes_pls_golite062009
  • ankyrin binding
    		•  4.69755754047169 bayes_pls_golite062009
  • receptor activity
    		•  4.66147271961356 bayes_pls_golite062009
  • alpha-actinin binding
    		•  4.57951951779666 bayes_pls_golite062009
  • actinin binding
    		•  4.57900103206288 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • cytokine receptor activity
    		•  4.08668869714207 bayes_pls_golite062009
  • growth factor binding
    		•  4.06808996928726 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • signal transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  3.5949595622742 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • receptor binding
    		•  2.38673889309915 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • peptide hormone binding
    		•  2.12033076929638 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • prolactin receptor activity
    		•  1.9556649101819 bayes_pls_golite062009
  • mercury ion binding
    		•  1.85843060232985 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.85720106085239 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.56410665522466 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.49217960276915 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42856560840953 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32813363771214 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.31663344632755 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  1.27192437373177 bayes_pls_golite062009
  • actin binding
    		•  1.21472460452555 bayes_pls_golite062009
  • DNA binding
    		•  1.2006039770643 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  1.15929762138929 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.15899955607967 bayes_pls_golite062009
  • heparin binding
    		•  1.15000556789505 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.12142142875217 bayes_pls_golite062009
  • kinase activity
    		•  1.11027658115625 bayes_pls_golite062009
  • cytokine activity
    		•  1.09433218752101 bayes_pls_golite062009
  • structural molecule activity
    		•  0.94240190391222 bayes_pls_golite062009
  • peptide binding
    		•  0.92031154055894 bayes_pls_golite062009
  • interleukin-6 binding
    		•  0.888638861691021 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  0.888638861691021 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.628488391922279 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.628488391922279 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • collagen binding
    		•  0.593745877718282 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transcription factor activity
    		•  0.557290274937694 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.54737137289904 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.47107517390107 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • pattern binding
    		•  0.44460010885883 bayes_pls_golite062009
  • growth factor activity
    		•  0.432629984792427 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.40600177052491 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • cell surface binding
    		•  0.366415248711076 bayes_pls_golite062009
  • interleukin-7 binding
    		•  0.301052531308189 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • transcription activator activity
    		•  0.135753557343301 bayes_pls_golite062009
  • actin filament binding
    		•  0.135484838710405 bayes_pls_golite062009
  • protease binding
    		•  0.12595904253108 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.115337814289139 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • transcription factor binding
    		•  0.075900818564989 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  0.0423783987133706 bayes_pls_golite062009
  • interleukin-11 binding
    		•  0.0423783987133706 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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