YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: LCB4

General Information:
Name(s) found: LCB4 / YOR171C [SGD]
Description(s) found:
Found 28 descriptions.
SHOW ALL
  • Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 624 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    soluble fraction [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed articleLink to PubMed article]
    Golgi apparatus [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: calcium-mediated signaling [IMPLink to PubMed article]
    sphingolipid metabolic process [IDALink to PubMed article]
    Molecular Function: D-erythro-sphingosine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVQKKLRAI LTDEGVLIKS QSHHMFNKHG QLRSGDSLSL LSCLSCLDDG TLSSDGGSFD  60
   61 EDDSLELLPL NTTIPFNRIL NAKYVNVGQK GFNNGKISSN PFQTENLSSS SENDDVENHS 120
  121 LSNDKAPVSE SQSFPKKDKW DTKTNTVKVS PDDSQDNSPS LGIKDNQQLI ELTFAVPKGH 180
  181 DVIPQKLTLL IDHVSRKSRA NTGEENISSG TVEEILEKSY ENSKRNRSIL VIINPHGGKG 240
  241 TAKNLFLTKA RPILVESGCK IEIAYTKYAR HAIDIAKDLD ISKYDTIACA SGDGIPYEVI 300
  301 NGLYRRPDRV DAFNKLAVTQ LPCGSGNAMS ISCHWTNNPS YAALCLVKSI ETRIDLMCCS 360
  361 QPSYMNEWPR LSFLSQTYGV IAESDINTEF IRWMGPVRFN LGVAFNIIQG KKYPCEVFVK 420
  421 YAAKSKKELK VHFLENKDKN KGCLTFEPNP SPNSSPDLLS KNNINNSTKD ELSPNFLNED 480
  481 NFKLKYPMTE PVPRDWEKMD SELTDNLTIF YTGKMPYIAK DTKFFPAALP ADGTIDLVIT 540
  541 DARIPVTRMT PILLSLDKGS HVLEPEVIHS KILAYKIIPK VESGLFSVDG EKFPLEPLQV 600
  601 EIMPMLCKTL LRNGRYIDTE FESM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) LCB4 LCB5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD1 LCB4 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LCB4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..160] deduced N/A No confident structure predictions are available.
    2 View Details [161..367] ORFEUS 7.4 Glycerol dehydrogenase
    3 View Details [368..428] deduced N/A No confident structure predictions are available.
    4 View Details [429..624] MSA 3.106994 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • kinase activity
    		•  2.76633393386992 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.49560915337842 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.43985991144271 bayes_pls_golite062009
  • transferase activity
    		•  1.63159199531284 bayes_pls_golite062009
  • catalytic activity
    		•  0.33446102778142 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle