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Protein Overview: HFA1

General Information:
Name(s) found: HFA1 / YMR207C [SGD]
Description(s) found:
Found 15 descriptions.
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  • Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2123 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: fatty acid biosynthetic process [IGILink to PubMed article]
    Molecular Function: acetyl-CoA carboxylase activity [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSIRKWAYE TFNDEKIIQF VVMATPDDLH ANSEYIRMAD QYVQVPGGTN NNNYANIDLI  60
   61 LDVAEQTDVD AVWAGWGHAS ENPCLPELLA SSQRKILFIG PPGRAMRSLG DKISSTIVAQ 120
  121 SAKIPCIPWS GSHIDTIHID NKTNFVSVPD DVYVRGCCSS PEDALEKAKL IGFPVMIKAS 180
  181 EGGGGKGIRR VDNEDDFIAL YRQAVNETPG SPMFVMKVVT DARHLEVQLL ADQYGTNITL 240
  241 FGRDCSIQRR HQKIIEEAPV TITKPETFQR MERAAIRLGE LVGYVSAGTV EYLYSPKDDK 300
  301 FYFLELNPRL QVEHPTTEMI SGVNLPATQL QIAMGIPMHM ISDIRKLYGL DPTGTSYIDF 360
  361 KNLKRPSPKG HCISCRITSE DPNEGFKPST GKIHELNFRS SSNVWGYFSV GNNGAIHSFS 420
  421 DSQFGHIFAV GNDRQDAKQN MVLALKDFSI RGEFKTPIEY LIELLETRDF ESNNISTGWL 480
  481 DDLILKNLSS DSKLDPTLAI ICGAAMKAYV FTEKVRNKYL ELLRRGQVPP KDFLKTKFPV 540
  541 DFIFDNNRYL FNVAQSSEEQ FILSINKSQC EVNVQKLSSD CLLISVDGKC HTVYWKDDIR 600
  601 GTRLSIDSNT IFLEAELNPT QVISPTPGKL VKYLVRSGDH VFAGQQYAEI EIMKMQMPLV 660
  661 AKSDGVIELL RQPGSIIEAG DVIAKLTLDS PSKANESSLY RGELPVLGPP LIEGSRPNHK 720
  721 LRVLINRLEN ILNGYHENSG IETTLKELIK ILRDGRLPYS EWDSQISTVR NRLPRQLNEG 780
  781 LGNLVKKSVS FPAKELHKLM KRYLEENTND HVVYVALQPL LKISERYSEG LANHECEIFL 840
  841 KLIKKYYAVE KIFENHDIHE ERNLLNLRRK DLTNLKKILC ISLSHANVVA KNKLVTAILH 900
  901 EYEPLCQDSS KMSLKFRAVI HDLASLESKW AKEVAVKARS VLLRGIFPPI KKRKEHIKTL 960
  961 LQLHIKDTGA ENIHSRNIYS CMRDFGNLIH SNLIQLQDLF FFFGHQDTAL SSIASEIYAR1020
 1021 YAYGNYQLKS IKIHKGAPDL LMSWQFSSLR NYLVNSDGES DEFTKLSKPP STSGKSSANS1080
 1081 FGLLVNMRAL ESLEKTLDEV YEQIHIPEER LSSGENSLIV NILSPIRYRS ENDLIKTLKI1140
 1141 KLHENERGLS KLKVNRITFA FIAANAPAVK FYSFDGTTYD EISQIRNMDP SYEAPLELGK1200
 1201 MSNYKIRSLP TYDSSIRIFE GISKFTPLDK RFFVRKIINS FMYNDQKTTE ENLKAEINAQ1260
 1261 VVYMLEHLGA VDISNSDLNH IFLSFNTVLN IPVHRLEEIV STILKTHETR LFQERITDVE1320
 1321 ICISVECLET KKPAPLRLLI SNKSGYVVKI ETYYEKIGKN GNLILEPCSE QSHYSQKSLS1380
 1381 LPYSVKDWLQ PKRYKAQFMG TTYVYDFPGL FHQAAIQQWK RYFPKHKLND SFFSWVELIE1440
 1441 QNGNLIKVNR EPGLNNIGMV AFEIMVQTPE YPEGRNMIVI SNDITYNIGS FGPREDLFFD1500
 1501 RVTNYARERG IPRIYLAANS GAKLGIAEEL IPLFRVAWND PSDPTKGFQY LYLAPKDMQL1560
 1561 LKDSGKGNSV VVEHKMVYGE ERYIIKAIVG FEEGLGVECL QGSGLIAGAT SKAYRDIFTI1620
 1621 TAVTCRSVGI GSYLVRLGQR TIQVEDKPII LTGASAINKV LGTDIYTSNL QIGGTQIMYK1680
 1681 NGIAHLTASN DMKAIEKIMT WLSYVPAKRD MSPPLLETMD RWDRDVDFKP AKQVPYEARW1740
 1741 LIEGKWDSNN NFQSGLFDKD SFFETLSGWA KGVIVGRARL GGIPVGVIAV ETKTIEEIIP1800
 1801 ADPANLDSSE FSVKEAGQVW YPNSAFKTAQ TINDFNYGEQ LPLIILANWR GFSGGQRDMY1860
 1861 NEVLKYGSFI VDALVDYKQP ILIYIPPFGE LRGGSWVVID PTINPEQMEM YADVESRGGV1920
 1921 LEPDGVVSIK YRKEKMIETM IRLDSTYGHL RRTLTEKKLS LEKQNDLTKR LKIRERQLIP1980
 1981 IYNQISIQFA DLHDRSTRML VKGVIRNELE WKKSRRFLYW RLRRRLNEGQ VIKRLQKKTC2040
 2041 DNKTKMKYDD LLKIVQSWYN DLDVNDDRAV VEFIERNSKK IDKNIEEFEI SLLIDELKKK2100
 2101 FEDRRGNIVL EELTRLVDSK RKR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ACC1 HFA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HFA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..528] PSI-BLAST 1000.0 No description for 2hjwA was found.
    2 View Details [529..607] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [608..687] PSI-BLAST 27.0 No description for 2dn8A was found.
    4 View Details [688..928] deduced N/A No confident structure predictions are available.
    5 View Details [929..1066] MSA 1.044968 View MSA. No confident structure predictions are available.
    6 View Details [1067..1314] deduced N/A No confident structure predictions are available.
    7 View Details [1315..2123] PSI-BLAST 1000.0 Acetyl-coenzyme A carboxylase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle