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Protein Overview: HOF1

General Information:
Name(s) found: HOF1 / YMR032W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 669 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck contractile ring [IDALink to PubMed articleLink to PubMed article]
    Biological Process: cytokinesis [IMPLink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    Molecular Function: cytoskeletal protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYSYEACFW DPNDNGVNIL LGHISQGIRS CDSMILFFKQ RSELEKDYAR RLGAITGKLD  60
   61 KDIGTNMDYG KLNETFNVVL SVEKARAQSH SKQSEILFRQ IYTDTKAFAA NLQARYTTLS 120
  121 GKIERLRMDK FNKKKGCEVL QKKLQDAQIR FRDLQLNENN MIGAKRVEHN KRELLKWESN 180
  181 SQEYKVQLDV LKQEYKASQK FWIHEWAQLS CELQEMENAR ISFLQSKLQQ FATSSMETYI 240
  241 LEQTKMDMLT NHLNSFTAAD EISTFSKENG TGRLKHKTSK GDMNSSANWA QMSSISTTSK 300
  301 KTESYMDNIR KLSSQLKETE NKRKLASIDK YEKPLPSPEV TMATQFRNST PVIRNETKVV 360
  361 ANPTLSLRSS PVQLQSNVDD SVLRQKPDKP RPIVGEEQLK PDEDSKNPDE KGLMVHKRNQ 420
  421 SLSSPSESSS SNPTDFSHIK KRQSMESMTT SVSSMANSID DSQRFAKSWN SSNRKRKSMS 480
  481 HLQVPSSASS RSDDGGRTPN SAHNLNEDDY NTRRDTSTST ILFKPPVAVR GTSRGHTHRQ 540
  541 SMIMQDSSNP IEDALYEMER IQSSSKPGTK TGNIMDERGV VRDRGITVTL PIVTSEGFPV 600
  601 IEYAKAMYPL IGNEAPGLAN FHKGDYLLIT EIVNKDWYKG EVYDNDRIDR NHRIGLIPYN 660
  661 FIQLLHQGL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) BEM1 BNI1 BNR1 BUD3 BUD6 CDC11 CDC12 CDC3 ELM1 HOF1 IQG1 MLC1 MLC2 MYO2 PEA2 PFY1 SAC6 SLA1 SPA2 SPH1 TPM1 TPM2 TWF1 VRP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MDM30 HOF1 2 Unpublished Fields Lab Data
    View Screen HOF1 APL2 2 Unpublished Fields Lab Data
    View Screen HOF1 TYE7 2 Unpublished Fields Lab Data
    View Screen NUP1 HOF1 2 Unpublished Fields Lab Data
    View Screen CTR86 HOF1 2 Unpublished Fields Lab Data
    View Screen SOG2 HOF1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HOF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..241] PSI-BLAST 20.0 Heavy meromyosin subfragment
    2 View Details [242..498] MSA 3.574991 View MSA. No confident structure predictions are available.
    3 View Details [499..594] MSA 1.438996 View MSA. No confident structure predictions are available.
    4 View Details [595..669] PSI-BLAST 18.154902 SH3 domain from nebulin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  1.90790462185992 bayes_pls_golite062009
  • binding
    		•  1.8819522899151 bayes_pls_golite062009
  • protein binding
    		•  1.62071874398997 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.292726989351706 bayes_pls_golite062009
  • hydrolase activity
    		•  0.147856264761915 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle