Protein Overview: DCW1

General Information:
Name(s) found:	DCW1 / YKL046C [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	449 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] anchored to plasma membrane [IDA]
Biological Process:	fungal-type cell wall biogenesis [IDA] budding cell bud growth [IGI]
Molecular Function:	mannosidase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLVNKVIGLL GVLFATRFTN AVELDLDNYE SLQNATSLIA YGLMDYYTGN QYGKTVGMFS  60
   61 DPYYWWEAGG AWGCMLDYWF FMDNDTYNDE IIAAMIHQAG DDNDYIPLNQ STTEGNDDQA 120
  121 FWGIAAMTAA ERNFTNPPEN EPQWLYLAQA VFNTMALRWD ADSCGGGLRW QIFVWNSGYD 180
  181 YKNTVSNGAL FHIAARLARY TGNQTYVDWA EKVYEWMVGV NLISNGTYKY VYDGVSIDDN 240
  241 CTKVTSYQWT YNQGLLLAGS AYLYNFTGSD LWHTRTKEFL NASQVFFHDG IVYEAACQGP 300
  301 NSCNTDQRSF KAYFARFLGV TAQLVPETRN QIMSWLNTSA IAAAKSCSGG TDGHTCGLNW 360
  361 FNGTWDGMYG LGEQMSALEV MVNTRALDKP APYTAENGGS SVGDGAAGTQ AQPTNLAPLN 420
  421 ITKGSKAGAG IITAVIGISI VACALWLVF

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ATP16 DCW1 FIT1 RPL29 RPP1A RPS26A SEM1 YMR118C
View Details	Qiu et al. (2008)		DCW1 DFG5 YLR194C YPS3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	DCW1	Huh WK, et al. (2003)

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
trehalase activity	4.23942428290504	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	3.78681366425382	bayes_pls_golite062009
alpha,alpha-trehalase activity	3.55712700159445	bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds	3.06084463737498	bayes_pls_golite062009
hydrolase activity	2.4324152075641	bayes_pls_golite062009
glucosidase activity	1.29725707798041	bayes_pls_golite062009
binding	1.09492132758288	bayes_pls_golite062009
catalytic activity	1.0882760267763	bayes_pls_golite062009
glucan 1,4-alpha-glucosidase activity	0.459801253504163	bayes_pls_golite062009
protein binding	0.208998323911823	bayes_pls_golite062009
intramolecular oxidoreductase activity	0.0402220178011703	bayes_pls_golite062009

No functions predicted.

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..258]	ORFEUS	8.89	Class I alpha-1;2-mannosidase, catalytic domain
2	View Details	[259..449]	ORFEUS	8.89	Class I alpha-1;2-mannosidase, catalytic domain

Protein Overview: DCW1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: