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Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains. Catalysis of the reaction: H2O + strictosidine = D-glucose + strictosidine aglycone. Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile. Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. Catalysis of the reaction: H2O + cholesteryl-beta-D-glucoside = D-glucose + cholesterol. Catalysis of the hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides. Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol. Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide. Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. Catalysis of the hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls and between N-acetyl-D-glucosamine residues in chitodextrins. Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. Catalysis of the reaction: hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose. Catalysis of the reaction: endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans. Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol. Catalysis of the reaction: endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product. Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides (exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan). Catalysis of the reaction: hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides. Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol. Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose. Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose. Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in beta-D-glucans containing 1,3- and 1,4-bonds. Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans. Catalysis of the reaction: endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S. Catalysis of the reaction: hydrolysis of 1,2-alpha-D- and 1,6-alpha-D- linkages in yeast mannan, releasing D-mannose. Catalysis of the reaction: hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan. Catalysis of the reaction: hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans. Catalysis of the reaction: hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose. Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose. Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative. Catalysis of the hydrolysis of trehalose or a trehalose derivative. Catalysis of the reaction: endohydrolysis of 1,4-beta-D-xylosyl links in some glucuronoarabinoxylans. Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. Catalysis of the reaction: hydrolysis of terminal, non-reducing 2,6-linked beta-D-fructofuranose residues in fructans. Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. Catalysis of the reaction: hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-1,4-linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted. Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides (endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan). Catalysis of the reaction: hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences. Catalysis of the reaction: hydrolysis of terminal, non-reducing 2,1-linked beta-D-fructofuranose residues in fructans. Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose. Catalysis of the reaction: 1,4-alpha-D-galacturonide(n) + H2O = 1,4-alpha-D-galacturonide(n-1) + D-galacturonate. Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains. Catalysis of the hydrolysis of amylose or an amylose derivative. Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin. Catalysis of the reaction: GDP-glucose + H2O = D-glucose + GDP. Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine. Catalysis of the reaction: endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides. Catalysis of the reaction: endohydrolysis of the D-mannuronide linkages of polymannuronate. Catalysis of the reaction: hydrolysis of 1,4-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends. Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends. Catalysis of the hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini. Catalysis of the reaction: hydrolysis of alpha-D-1,2-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans. Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine. Catalysis of the reaction: hydrolysis of 1,2-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose. Catalysis of the reaction: endohydrolysis of 1,4-alpha-D-galactosaminidic linkages in poly(D-galactosamine). Catalysis of the reaction: endohydrolysis of 1,4-beta-D-galactosidic linkages in keratan sulfate. Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in desulfated dermatan. Catalysis of the reaction: H2O + glycyrrhizinate = 1,2-beta-D-glucuronosyl-D-glucuronate + glycyrrhetinate. Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins. Catalysis of the reaction: hydrolysis of 1,6-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains. Catalysis of the reaction: hydrolysis of 1,6-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains. Catalysis of the reaction: hydrolysis of terminal D-galactosyl-N-acetyl-alpha-D-galactosaminidic residues from a variety of glycopeptides and glycoproteins. Catalysis of the reaction: endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides. Catalysis of the reaction: hydrolysis of 1,4-beta-D-mannosidic linkages in 1,4-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends. Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends. Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine. Catalysis of the reaction: endohydrolysis of 1,4-beta-D-galactosidic linkages in blood group A and B substances. Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol. Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. Catalysis of the reaction: hydrolysis of terminal, non-reducing N-acetylmuramic residues. Catalysis of the endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. Catalysis of the reaction: random hydrolysis of 1,3-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide. Catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans. Catalysis of the hydrolysis of (16)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan. Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose. Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc. Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2-,6-disulfo-D-glucosamine. Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. Catalysis of the reaction: hydrolysis of terminal 1,3-alpha-D-glucosidic links in 1,3-alpha-D-glucans. Catalysis of the endohydrolysis of 1,5-alpha-arabinofuranosidic linkages in 1,5-arabinans. Catalysis of the reaction: endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans. Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate. Catalysis of the reaction: hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate. Catalysis of the reaction: hydrolysis of 1,4-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product. Catalysis of the reaction: hydrolysis of 1,2- and 1,3-linkages in yeast mannan, releasing mannose. Catalysis of the reaction: hydrolysis of successive xylose residues from the non-reducing termini of 1,3-beta-D-xylans. Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides. Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine. Catalysis of the reaction: random hydrolysis of 1,2-glucosidic linkages in 1,2-beta-D-glucans. Catalysis of the reaction: hydrolysis of 2,6-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain. Catalysis of the reaction: H2O + quercitrin = L-rhamnose + quercetin. Catalysis of the reaction: endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds. Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends. Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. Catalysis of the hydrolysis of any O-glycosyl bond. Catalysis of the hydrolysis of any glycosyl bond. Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar. Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains. Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans. Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides. Catalysis of the reaction: random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate. Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose. Catalysis of the reaction: random hydrolysis of 1,3-beta-D-glycosidic linkages in 1,3-beta-D-xylans. Catalysis of the reaction: hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides. Catalysis of the reaction: hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides. Catalysis of the reaction: endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran. Catalysis of the reaction: endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3. Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. Catalysis of the hydrolysis of pullulan to panose (6-a-D-glucosylmaltose). Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan. Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin. Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose). Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid. Catalysis of the reaction: endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate. Catalysis of the hydrolysis of (1,6)-a-D-glucosidic linkages in pullulan [a linear polymer of a-(1,6)-linked maltotriose units] and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: hydrolase activity, hydrolyzing O-glycosyl compounds
Acc: GO:0004553
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of any O-glycosyl bond.
Synonyms:
  • GO:0016800
  • O-glucosyl hydrolase activity
Proteins in PDR annotated with:
   This term: 439 [Search]
   Term or descendants: 1137 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle