YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: INP51

General Information:
Name(s) found: INP51 / YIL002C [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 946 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    Biological Process: cellular cell wall organization [IGILink to PubMed article]
    inositol lipid-mediated signaling [TASLink to PubMed article]
    endocytosis [IGILink to PubMed article]
    dephosphorylation [IDALink to PubMed article]
    phosphoinositide dephosphorylation [IDALink to PubMed article]
    Molecular Function: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [IDALink to PubMed article][IMPLink to PubMed article]
    [NOT]inositol-polyphosphate 5-phosphatase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLFIGRRSR SIVISSNNYC LSFQRLRSIP GASSQQRQLS KTPSVTIKSY PDTDLSSDSN  60
   61 YLEVKSCIFN GLLGLVCLNG DIYVAVISGV QNVGFPRWKL IDHQVRPSES IYKVLDVDFY 120
  121 SLENDVFDYL LCERSEQNYD KLIHEHPCGP LKKLFSDGTF YYSRDFDISN IVKNHGLSHN 180
  181 LEYTVDNQDL SFIWNANLAS EVINWRSKIS NEEKQLFANA GFLTFVIRGY CKTALIEDGP 240
  241 NTASITIISR ISTESKQDTL ELEGISEDGR VSLFVETEIV VTTEKFIFSY TQVNGSIPLF 300
  301 WESVESQLLY GKKIKVTKDS IEAQGAFDRH FDNLTSKYGV VSIVNIIKPK SESQEKLALT 360
  361 YKDCAESKGI KITNIEYSSS VLTKSPHKLL YLLKQDIYEF GAFAYDISRG IYFAKQTGVL 420
  421 RISAFDSIEK PNTVERLVSK EVLELTTNEI DVFELTSPFL DAHDKLWSEN YYWLDRTYTK 480
  481 HTKNSGKYTK VYSKLFGSRV RLYDPLHIYI SQYLKQLRSK YTFEKDISIF AGTFNISGKI 540
  541 PKDDIKDWIF PKSMSKEDEM ADLYVIGLEE VVELTPGHML ATDPYVRQFW EKKILTLLNG 600
  601 PGRKKKYIRL WSTQLGGILL LLFMNETEYS KVKHIEGDVK KTGFGGMASN KGAVAVSFKY 660
  661 SATRFCVLVS HLAAGLENVE QRHNDYKTIA KSIRFSKGLR IKDHDAIIWM GDFNYRILMS 720
  721 NEDVRRKIVS KEYASLFEKD QLNQQMIAGE SFPYFHEMAI DFPPTYKFDP GTKNYDTSEK 780
  781 MRIPAWTDRI LSRGEVLEQL EYKCCEDILF SDHRPVYAIF RARVTVVDEQ KKTTLGTQIY 840
  841 EKIMERLEGL DDDEKIAVLS DDAFVIESFE GSDSIAGPTH SPTPIPEPKR GRKLPPPSSD 900
  901 LKKWWIGSGK QVKVVLDVDP AVYMINPKRD PNPFVENEDE PLFIER

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) INP51 INP52 INP53

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen BDF1 INP51 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data INP51 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..408] Pfam 149.107905 SacI homology domain No confident structure predictions are available.
    2 View Details [409..496] deduced N/A No confident structure predictions are available.
    3 View Details [497..879] PSI-BLAST 962.9897 Synaptojanin, IPP5C domain
    4 View Details [880..946] deduced N/A No confident structure predictions are available.
    5 View Details [844..946] PSI-BLAST 18.522879 No description for 2qv2A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • hydrolase activity, acting on ester bonds
    		•  6.16986356176974 bayes_pls_golite062009
  • phosphatase activity
    		•  5.90350467872925 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  5.84927924311254 bayes_pls_golite062009
  • phosphatidylinositol bisphosphate phosphatase activity
    		•  5.76202422677892 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
    		•  5.57319461575586 bayes_pls_golite062009
  • phosphoinositide 5-phosphatase activity
    		•  5.57319461575586 bayes_pls_golite062009
  • inositol-polyphosphate 5-phosphatase activity
    		•  4.20215185632047 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  3.88924621938812 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  3.07322777760243 bayes_pls_golite062009
  • phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
    		•  2.64934277728302 bayes_pls_golite062009
  • phosphatidylinositol-4-phosphate phosphatase activity
    		•  2.64934277728302 bayes_pls_golite062009
  • inositol trisphosphate phosphatase activity
    		•  2.32855198081691 bayes_pls_golite062009
  • hydrolase activity
    		•  2.1345957248514 bayes_pls_golite062009
  • phosphatidylinositol-3-phosphatase activity
    		•  1.98439062808392 bayes_pls_golite062009
  • catalytic activity
    		•  1.76511376991978 bayes_pls_golite062009
  • DNA binding
    		•  1.45924870577723 bayes_pls_golite062009
  • phosphatidylinositol trisphosphate phosphatase activity
    		•  1.43486520454637 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.38966944580562 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.37597495586534 bayes_pls_golite062009
  • binding
    		•  1.31660174492743 bayes_pls_golite062009
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
    		•  0.938520838175434 bayes_pls_golite062009
  • nuclease activity
    		•  0.782488606133604 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.620825895803427 bayes_pls_golite062009
  • protein binding
    		•  0.476649214025345 bayes_pls_golite062009
  • transcription activator activity
    		•  0.239217168608234 bayes_pls_golite062009
  • exonuclease activity
    		•  0.219613338022829 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.213742479001316 bayes_pls_golite062009
  • transcription factor binding
    		•  0.19603200433138 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  0.137101173922861 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle