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View Structure Prediction Details

Protein: INP51
Organism: Saccharomyces cerevisiae
Length: 946 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INP51.

Description E-value Query
Range
Subject
Range
INP51 - Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sa...
gi|190406224 - gi|190406224|gb|EDV09491.1| phosphatidylinositol 4,5-bisphosphate 5-phosphatase [Saccharomyces cerev...
INP51_YEAST - Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51 OS=Saccharomyces cerevisiae (strain ATCC 2...
gi|151943157 - gi|151943157|gb|EDN61492.1| phosphatidylinositol 4,5-bisphosphate 5-phosphatase [Saccharomyces cerev...
0.0 [1..946] [1..946]
SYJ1_SCHPO - Inositol-1,4,5-trisphosphate 5-phosphatase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ...
syj1 - inositol-polyphosphate 5-phosphatase (synaptojanin homolog 1)
0.0 [1..944] [1..957]
gi|2702321 - gi|2702321|gb|AAC51921.1| synaptojanin [Homo sapiens]
0.0 [22..875] [9..914]
SYNJ1_RAT, SYJ1_RAT - (Q62910) Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1), (Q629...
0.0 [22..875] [9..914]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [22..875] [9..914]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
0.0 [22..875] [9..914]
SYNJ1_BOVIN - Synaptojanin-1 (Fragment) OS=Bos taurus GN=SYNJ1 PE=1 SV=2
0.0 [22..875] [9..914]
gi|3241985 - gi|3241985|gb|AAC40141.1| synaptojanin 2 isoform beta [Mus musculus]
0.0 [43..879] [35..921]

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Predicted Domain #1
Region A:
Residues: [1-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLFIGRRSR SIVISSNNYC LSFQRLRSIP GASSQQRQLS KTPSVTIKSY PDTDLSSDSN  60
   61 YLEVKSCIFN GLLGLVCLNG DIYVAVISGV QNVGFPRWKL IDHQVRPSES IYKVLDVDFY 120
  121 SLENDVFDYL LCERSEQNYD KLIHEHPCGP LKKLFSDGTF YYSRDFDISN IVKNHGLSHN 180
  181 LEYTVDNQDL SFIWNANLAS EVINWRSKIS NEEKQLFANA GFLTFVIRGY CKTALIEDGP 240
  241 NTASITIISR ISTESKQDTL ELEGISEDGR VSLFVETEIV VTTEKFIFSY TQVNGSIPLF 300
  301 WESVESQLLY GKKIKVTKDS IEAQGAFDRH FDNLTSKYGV VSIVNIIKPK SESQEKLALT 360
  361 YKDCAESKGI KITNIEYSSS VLTKSPHKLL YLLKQDIYEF GAFAYDIS

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 149.107905
Match: PF02383
Description: SacI homology domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [409-496]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGIYFAKQTG VLRISAFDSI EKPNTVERLV SKEVLELTTN EIDVFELTSP FLDAHDKLWS  60
   61 ENYYWLDRTY TKHTKNSGKY TKVYSKLF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [497-879]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSRVRLYDPL HIYISQYLKQ LRSKYTFEKD ISIFAGTFNI SGKIPKDDIK DWIFPKSMSK  60
   61 EDEMADLYVI GLEEVVELTP GHMLATDPYV RQFWEKKILT LLNGPGRKKK YIRLWSTQLG 120
  121 GILLLLFMNE TEYSKVKHIE GDVKKTGFGG MASNKGAVAV SFKYSATRFC VLVSHLAAGL 180
  181 ENVEQRHNDY KTIAKSIRFS KGLRIKDHDA IIWMGDFNYR ILMSNEDVRR KIVSKEYASL 240
  241 FEKDQLNQQM IAGESFPYFH EMAIDFPPTY KFDPGTKNYD TSEKMRIPAW TDRILSRGEV 300
  301 LEQLEYKCCE DILFSDHRPV YAIFRARVTV VDEQKKTTLG TQIYEKIMER LEGLDDDEKI 360
  361 AVLSDDAFVI ESFEGSDSIA GPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 962.9897
Match: 1i9yA_
Description: Synaptojanin, IPP5C domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [880-946]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSPTPIPEPK RGRKLPPPSS DLKKWWIGSG KQVKVVLDVD PAVYMINPKR DPNPFVENED  60
   61 EPLFIER

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on ester bonds 6.16986356176974 bayes_pls_golite062009
phosphatase activity 5.90350467872925 bayes_pls_golite062009
phosphoric ester hydrolase activity 5.84927924311254 bayes_pls_golite062009
phosphatidylinositol bisphosphate phosphatase activity 5.76202422677892 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 5.57319461575586 bayes_pls_golite062009
phosphoinositide 5-phosphatase activity 5.57319461575586 bayes_pls_golite062009
inositol-polyphosphate 5-phosphatase activity 4.20215185632047 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 3.88924621938812 bayes_pls_golite062009
lipid phosphatase activity 3.07322777760243 bayes_pls_golite062009
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity 2.64934277728302 bayes_pls_golite062009
phosphatidylinositol-4-phosphate phosphatase activity 2.64934277728302 bayes_pls_golite062009
inositol trisphosphate phosphatase activity 2.32855198081691 bayes_pls_golite062009
hydrolase activity 2.1345957248514 bayes_pls_golite062009
phosphatidylinositol-3-phosphatase activity 1.98439062808392 bayes_pls_golite062009
catalytic activity 1.76511376991978 bayes_pls_golite062009
DNA binding 1.45924870577723 bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity 1.43486520454637 bayes_pls_golite062009
nucleic acid binding 1.38966944580562 bayes_pls_golite062009
transcription regulator activity 1.37597495586534 bayes_pls_golite062009
binding 1.31660174492743 bayes_pls_golite062009
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity 0.938520838175434 bayes_pls_golite062009
nuclease activity 0.782488606133604 bayes_pls_golite062009
deoxyribonuclease activity 0.620825895803427 bayes_pls_golite062009
protein binding 0.476649214025345 bayes_pls_golite062009
transcription activator activity 0.239217168608234 bayes_pls_golite062009
exonuclease activity 0.219613338022829 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.213742479001316 bayes_pls_golite062009
transcription factor binding 0.19603200433138 bayes_pls_golite062009
phosphoric diester hydrolase activity 0.137101173922861 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [844-946]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERLEGLDDD EKIAVLSDDA FVIESFEGSD SIAGPTHSPT PIPEPKRGRK LPPPSSDLKK  60
   61 WWIGSGKQVK VVLDVDPAVY MINPKRDPNP FVENEDEPLF IER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.522879
Match: 2qv2A
Description: No description for 2qv2A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle