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Protein Overview: ARN2

General Information:
Name(s) found: ARN2 / YHL047C [SGD]
Description(s) found:
Found 20 descriptions.
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  • Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 637 amino acids

    Gene Ontology:
    Cellular Component: endosome [TASLink to PubMed article]
    cytoplasmic membrane-bounded vesicle [TASLink to PubMed article]
    plasma membrane [ISSLink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IMPLink to PubMed article]
    siderophore-iron transport [IDALink to PubMed article][IMPLink to PubMed article]
    siderophore metabolic process [IMPLink to PubMed article]
    Molecular Function: siderophore-iron transmembrane transporter activity [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIEVPEDNRS SQTKRKNTEK NCNELMVDEK MDDDSSPRDE MKDKLKGTKS LIIRKSELMA  60
   61 KKYDTWQLKA IFLFSAFICT FAYGLDSSIR GTYMTYAMNS YSAHSLISTV SVIVLMISAV 120
  121 SQVIFGGLSD IFGRLTLFLV SIVLYIVGTI IQSQAYDVQR YAAGAVFYYV GLVGVMLQVV 180
  181 LMLSDNSSLK WRLFYTLIPS WPSIITTWVS GSVVEAANPL ENWSWNIAMW AFIFPLCCIP 240
  241 LILCMLHMRW KVRNDVEWKE LQDEKSYYQT HGLVQMLVQL FWKLDVVGVL LFTAGVGCIL 300
  301 VPLTLAGGVS TNWRNSKIIG PFVLGFVLVP GFIYWESRLA LVPFAPFKLL KDRGVWAPLG 360
  361 IMFFICFVYQ MAAGYLYTIL VVAVDESASS ATRIINLYSF VTAVVAPFLG LIVTRSSRLK 420
  421 SYIIFGGSLY FITMGLFYRY RSGQDADGGI IAGMVIWGLS SCLFDYPTIV SIQSVTSHEN 480
  481 MATVTALNYT VFRIGGAVAA AISGAIWTQS LYPKLLHYMG DADLATAAYG SPLTFILSNP 540
  541 WGTPVRSAMV EAYRHVQKYE VIVALVFSAP MFLLTFCVRD PRLTEDFAQK LPDREYVQTK 600
  601 EDDPINDWIA KRFAKALGGH KKDLQNPNRI CVRKNDL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ARN1 ARN2 ENB1 FET3 FTR1 SIT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..53] deduced N/A No confident structure predictions are available.
    2 View Details [54..270] PSI-BLAST 8.30103 No description for 1lviA_ was found.
    3 View Details [271..329] deduced N/A No confident structure predictions are available.
    4 View Details [330..637] MSA 21.822997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  5.46247398538901 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.58978526526921 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.31967711223954 bayes_pls_golite062009
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • binding
    		•  1.26757615356623 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  1.24023641504332 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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