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Protein Overview: PCL6

General Information:
Name(s) found: PCL6 / YER059W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 420 amino acids

    Gene Ontology:
    Cellular Component: cyclin-dependent protein kinase holoenzyme complex [TASLink to PubMed article]
    Biological Process: regulation of glycogen biosynthetic process [IGILink to PubMed article]
    regulation of glycogen catabolic process [IGILink to PubMed article]
    Molecular Function: cyclin-dependent protein kinase regulator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIKGDSPSS TNASSSPKST YSIQSDDKAN LGSGNVDIRT DNSQQDSNNR RDIVVVTRVA  60
   61 SEETLESQSS TSSMGIRPES SFNYEDASNQ ARVEMNNRVH GSNMNTINKY YPVRFPKNNE 120
  121 RQLSDTNNLN EKVQGTHTVQ SSTQEDKILD GDTSNSQVTP SLNIAEFPTD KLLKMLTALL 180
  181 TKIIKSNDRT AATNPSLTQE IENGRCLALS DNEKKYLSPV LGFRGKHVPQ IGLDQYFQRI 240
  241 QKYCPTTNDV FLSLLVYFDR ISKRCNSVTT TPKTNTAKHE SPSNESSLDK ANRGADKMSA 300
  301 CNSNENNEND DSDDENTGVQ RDSRAHPQMF VMDSHNIHRL IIAGITVSTK FLSDFFYSNS 360
  361 RYSRVGGISL QELNHLELQF LVLCDFELLI SVNELQRYAD LLYRFWNNAK AQSQALVTGM 420
  421

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MMR1 PCL6 PCL8 PHO85
    View Details Ho Y, et al. (2002) PCL6 PHO85
    View Details Qiu et al. (2008) PCL10 PCL6 PCL7 PCL8 PHO80

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC28 PCL6 2 Unpublished Fields Lab Data
    View Screen PHO85 PCL6 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PCL6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..127] deduced N/A No confident structure predictions are available.
    2 View Details [128..308] MSA 2.041996 View MSA. No confident structure predictions are available.
    3 View Details [309..420] ORFEUS 7.39 Viral cyclin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • cyclin-dependent protein kinase regulator activity
    		•  5.56043783950774 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  3.56449795345173 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  2.42298912398512 bayes_pls_golite062009
  • kinase regulator activity
    		•  2.38269740782712 bayes_pls_golite062009
  • binding
    		•  2.37916921859542 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.35246308363499 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.66282585660189 bayes_pls_golite062009
  • DNA binding
    		•  1.62111826122916 bayes_pls_golite062009
  • protein binding
    		•  1.37207701115974 bayes_pls_golite062009
  • transcription factor activity
    		•  0.942934833538458 bayes_pls_golite062009
  • protein kinase activity
    		•  0.936843200737436 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.790804751794544 bayes_pls_golite062009
  • kinase activity
    		•  0.76336575273867 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.681773164635831 bayes_pls_golite062009
  • hydrolase activity
    		•  0.639492478283697 bayes_pls_golite062009
  • transcription factor binding
    		•  0.578625558009429 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.553775750179295 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.529818399573297 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.461517963237846 bayes_pls_golite062009
  • kinase binding
    		•  0.288717702650258 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.0259350481945262 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle