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View Structure Prediction Details

Protein: PCL6
Organism: Saccharomyces cerevisiae
Length: 420 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PCL6.

Description E-value Query
Range
Subject
Range
PCL6 - Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; ...
gi|207345958 - gi|207345958|gb|EDZ72603.1| YER059Wp-like protein [Saccharomyces cerevisiae AWRI1631]
PCL6_YEAST - PHO85 cyclin-6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PCL6 PE=1 SV=1
0.0 [1..420] [1..420]
gi|25493992, gi|... - gi|2982283|gb|AAC32127.1| PREG-like protein [Picea mariana], pir||T52062 PREG-like protein [imported...
8.0E-54 [243..414] [65..229]
CCU43_ARATH - Cyclin-U4-3 OS=Arabidopsis thaliana GN=CYCU4-3 PE=1 SV=1
3.0E-49 [230..407] [4..174]
gi|18766393 - gi|18766393|gb|AAL78998.1|AF465728_1 cyclin fold protein 1 variant a [Homo sapiens]
2.0E-44 [225..409] [38..260]
gi|15451434 - gi|15451434|dbj|BAB64521.1| hypothetical protein [Macaca fascicularis]
2.0E-43 [189..409] [13..245]

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Predicted Domain #1
Region A:
Residues: [1-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIKGDSPSS TNASSSPKST YSIQSDDKAN LGSGNVDIRT DNSQQDSNNR RDIVVVTRVA  60
   61 SEETLESQSS TSSMGIRPES SFNYEDASNQ ARVEMNNRVH GSNMNTINKY YPVRFPKNNE 120
  121 RQLSDTN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [128-308]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLNEKVQGTH TVQSSTQEDK ILDGDTSNSQ VTPSLNIAEF PTDKLLKMLT ALLTKIIKSN  60
   61 DRTAATNPSL TQEIENGRCL ALSDNEKKYL SPVLGFRGKH VPQIGLDQYF QRIQKYCPTT 120
  121 NDVFLSLLVY FDRISKRCNS VTTTPKTNTA KHESPSNESS LDKANRGADK MSACNSNENN 180
  181 E

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
cyclin-dependent protein kinase regulator activity 5.56043783950774 bayes_pls_golite062009
cyclin-dependent protein kinase activity 3.56449795345173 bayes_pls_golite062009
protein kinase regulator activity 2.42298912398512 bayes_pls_golite062009
kinase regulator activity 2.38269740782712 bayes_pls_golite062009
binding 2.37916921859542 bayes_pls_golite062009
transcription regulator activity 2.35246308363499 bayes_pls_golite062009
nucleic acid binding 1.66282585660189 bayes_pls_golite062009
DNA binding 1.62111826122916 bayes_pls_golite062009
protein binding 1.37207701115974 bayes_pls_golite062009
transcription factor activity 0.942934833538458 bayes_pls_golite062009
protein kinase activity 0.936843200737436 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.790804751794544 bayes_pls_golite062009
kinase activity 0.76336575273867 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.681773164635831 bayes_pls_golite062009
hydrolase activity 0.639492478283697 bayes_pls_golite062009
transcription factor binding 0.578625558009429 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.553775750179295 bayes_pls_golite062009
protein serine/threonine kinase activity 0.529818399573297 bayes_pls_golite062009
enzyme regulator activity 0.461517963237846 bayes_pls_golite062009
kinase binding 0.288717702650258 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.0259350481945262 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [309-420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDDSDDENTG VQRDSRAHPQ MFVMDSHNIH RLIIAGITVS TKFLSDFFYS NSRYSRVGGI  60
   61 SLQELNHLEL QFLVLCDFEL LISVNELQRY ADLLYRFWNN AKAQSQALVT GM

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.39
Match: 1g3nC
Description: Viral cyclin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle