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Protein Overview: YEN1

General Information:
Name(s) found: YEN1 / YER041W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 759 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: single-stranded DNA specific endodeoxyribonuclease activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVSQIWEFL KPYLQDSRIP LRKFVIDFNK SQKRAPRIAI DAYGWLFECG FIQNIDISPR  60
   61 SRSRSRSPTR SPRDSDIDSS QEYYGSRSYT TTGKAVINFI SRLKELLSLN VEFLLVFDGV 120
  121 MKPSFKRKFN HEQNATTCDD EKEYYSSWEQ HVKNHEVYGN CKGLLAPSDP EFISLVRKLL 180
  181 DLMNISYVIA CGEGEAQCVW LQVSGAVDFI LSNDSDTLVF GGEKILKNYS KFYDDFGPSS 240
  241 ITSHSPSRHH DSKESFVTVI DLPKINKVAG KKFDRLSLLF FSVLLGADYN RGVKGLGKNK 300
  301 SLQLAQCEDP NFSMEFYDIF KDFNLEDLTS ESLRKSRYRL FQKRLYLYCK DHSVELFGRN 360
  361 YPVLLNQGSF EGWPSTVAIM HYFHPIVQPY FDEEVLSDKY INMAGNGHYR NLNFNELKYF 420
  421 LQSLNLPQIS SFDKWFHDSM HEMFLLREFL SIDESDNIGK GNMRITEEKI MNIDGGKFQI 480
  481 PCFKIRYTTF LPNIPISSQS PLKRSNSPSR SKSPTRRQMD IMEHPNSLWL PKYLIPQSHP 540
  541 LVIQYYETQQ LIQKEKEKKG KKSNKSRLPQ KNNLDEFLRK HTSPIKSIGK VGESRKEILE 600
  601 PVRKRLFVDT DEDTSLEEIP APTRLTTVDE HSDNDDDSLI FVDEITNSQS VLDSSPGKRI 660
  661 RDLTQDEQVD VWKDVIEISP IKKSRTTNAE KNPPESGLKS RSSITINARL QGTKMLPPNL 720
  721 TAPRLEREHS SVLDQLVTDA QDTVDRFVAC DSDSSSTIE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Ho Y, et al. (2002) FPR4 POL30 RPF2 YEN1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HXK2 YEN1 1 Unpublished Fields Lab Data
    View Screen ILM1 YEN1 1 Lockshon D, et al. (2006)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122]
    [139..273]
    [321..371]    		 PSI-BLAST 133.512579 Flap endonuclease-1 (Fen-1 nuclease)
    2 View Details [123..138]
    [274..320]    		 PSI-BLAST 133.512579 Flap endonuclease-1 (Fen-1 nuclease)
    3 View Details [372..759] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nuclease activity
    		•  1.01613710322657 bayes_pls_golite062009
  • flap endonuclease activity
    		•  0.82585431543948 bayes_pls_golite062009
  • exonuclease activity
    		•  0.824724356048525 bayes_pls_golite062009
  • binding
    		•  0.689831953215996 bayes_pls_golite062009
  • catalytic activity
    		•  0.608920813710592 bayes_pls_golite062009
  • hydrolase activity
    		•  0.474100428865975 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.456180294825256 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.37506170847971 bayes_pls_golite062009
  • endonuclease activity
    		•  0.313338552386604 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.261085038325444 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.15331824596114 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.152177969184321 bayes_pls_golite062009
  • DNA binding
    		•  0.0968248862430132 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle