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Protein Overview: RKM4

General Information:
Name(s) found: RKM4 / YDR257C [SGD]
Description(s) found:
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  • gi|6320463|ref|NP_010543.1| Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins; Set7p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51830266|gb|AAU09704.1| YDR257C [Saccharomyces cerevisiae] [NCBI NR]
  • gi|46577338|sp|Q12504.1|RKM4_YEAST RecName: Full=Ribosomal N-lysine methyltransferase 4; AltName: Full=SET domain-containing protein 7 [NCBI NR]
  • pir||S67314 regulatory protein RMS1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1226033|emb|CAA94096.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1136212|emb|CAA92714.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • SET domain-containing protein RMS1 OS=Saccharomyces cerevisiae GN=RMS1 PE=1 SV=1 [Swiss-Prot]
  • Ribosomal N-lysine methyltransferase 4 OS=Saccharomyces cerevisiae GN=RKM4 PE=1 SV=1 [Swiss-Prot]
  • SET7 Regulatory protein [mips]
  • Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein [SGD]
  • RMS1, Chr IV from 969981-971465, reverse complement [yeast_orfs2]
  • Chr IV from 969981-971465, reverse complement [yeastorf3.fasta]
  • Chr IV from 971465-969981, reverse complement [yeastorf5.fasta]
  • >Q12504 (Q12504) Hypothetical protein YD9320A [4932.FASTACCERV.txt]
  • SET7 SGDID:S0002665, Chr IV from 971466-969982, reverse complement, Verified ORF [yeastflysequest.fasta]
  • SET7 SGDID:S0002665, Chr IV from 971468-969984, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins [Saccharomyces cerevisiae]gi|51830266|gb|AAU09704.1| YDR257C [Saccharomyces cerevisiae]gi|1226033|emb|CAA94096.1| unknown [Saccharo [nrdb_11152004_Chlamydomonas]
  • (Q12504) Putative transcription regulator RMS1 [cerv4932.FASTAC]
  • SET7 SGDID:S000002665, Chr IV from 971468-969984, reverse complement, Verified ORF, "Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • SET7 SGDID:S000002665, Chr IV from 971470-969986, reverse complement, Verified ORF, "Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins" [yeast-contam.fasta]
  • SET7 SGDID:S000002665, Chr IV from 971471-969987, reverse complement, Verified ORF, "Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • RKM4 SGDID:S000002665, Chr IV from 971471-969987, reverse complement, Verified ORF, "Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein" [yeast-200209-contam.fasta]
  • YDR257C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Putative transcription regulator RMS1 [nr-271106-contam.fasta]
  • Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins; Set7p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Ribosomal N-lysine methyltransferase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RKM4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • RKM4 SGDID:S000002665, Chr IV from 971474-969990, Genome Release 64-1-1, reverse complement, Verified ORF, "Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein" [yeast-030211-contam.fasta]
  • RKM4 SGDID:S000002665, Chr IV from 971474-969990, Genome Release 64-2-1, reverse complement, Verified ORF, "Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein" [20141208_orf_trans.fasta]
  • YDR257C SGDID:S000002665, Chr IV from 971474-969990, Genome Release 64-1-1, reverse complement, Verified ORF, "Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • Ribosomal lysine N-methyltransferase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RKM4 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Saccharomyces cerevisiae
    Length: 494 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDFSRDTEN FVCWLKTTAE IEVSPKIEIK DLCCDNQGRA VVATQKIKKD ETLFKIPRSS  60
   61 VLSVTTSQLI KDYPSLKDKF LNETGSWEGL IICILYEMEV LQERSRWAPY FKVWNKPSDM 120
  121 NALIFWDDNE LQLLKPSLVL ERIGKKEAKE MHERIIKSIK QIGGEFSRVA TSFEFDNFAY 180
  181 IASIILSYSF DLEMQDSSVN ENEEEETSEE ELENERYLKS MIPLADMLNA DTSKCNANLT 240
  241 YDSNCLKMVA LRDIEKNEQV YNIYGEHPNS ELLRRYGYVE WDGSKYDFGE VLLENIVEAL 300
  301 KETFETNTEF LDRCIDILRN NANIQEFLEG EEIVLDSYDC YNNGELLPQL ILLVQILTIL 360
  361 CQIPGLCKLD IKAMERQVER IVKKCLQLIE GARATTNCSA TWKRCIMKRL ADYPIKKCVS 420
  421 IEKPSKGNSL TREELRDVMA RRVLKSEIDS LQVCEETIDK NYKVIPDEKL LTNILKRKLT 480
  481 EEEKSSVKRP CVKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RKM4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..281] MSA 19.062997 View MSA. No confident structure predictions are available.
    2 View Details [282..494] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • histone methyltransferase activity
    		•  6.20878333364554 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  6.08778683840554 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  5.45106430536252 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  5.45106430536252 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  5.45106430536252 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.98411678860954 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K9 specific)
    		•  3.54138873512018 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.69428385009711 bayes_pls_golite062009
  • methyltransferase activity
    		•  2.33114816345072 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.25175257044903 bayes_pls_golite062009
  • binding
    		•  1.67469558504376 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.29511015534184 bayes_pls_golite062009
  • protein binding
    		•  1.07532079834012 bayes_pls_golite062009
  • transferase activity
    		•  0.653108419761009 bayes_pls_golite062009
  • chromatin binding
    		•  0.628375771647179 bayes_pls_golite062009
  • catalytic activity
    		•  0.414641636618101 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle