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Protein Overview: TRM82

General Information:
Name(s) found: TRM82 / YDR165W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 444 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    tRNA methylation [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    tRNA (guanine-N7-)-methyltransferase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVIHPLQNL LTSRDGSLVF AIIKNCILSF KYQSPNHWEF AGKWSDDFDK IQESRNTTAK  60
   61 EQQGQSSENE NENKKLKSNK GDSIKRTAAK VPSPGLGAPP IYSYIRNLRL TSDESRLIAC 120
  121 ADSDKSLLVF DVDKTSKNVL KLRKRFCFSK RPNAISIAED DTTVIIADKF GDVYSIDINS 180
  181 IPEEKFTQEP ILGHVSMLTD VHLIKDSDGH QFIITSDRDE HIKISHYPQC FIVDKWLFGH 240
  241 KHFVSSICCG KDYLLLSAGG DDKIFAWDWK TGKNLSTFDY NSLIKPYLND QHLAPPRFQN 300
  301 ENNDIIEFAV SKIIKSKNLP FVAFFVEATK CIIILEMSEK QKGDLALKQI ITFPYNVISL 360
  361 SAHNDEFQVT LDNKESSGVQ KNFAKFIEYN LNENSFVVNN EKSNEFDSAI IQSVQGDSNL 420
  421 VTKKEEIYPL YNVSSLRKHG EHYS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TRM8 TRM82
    View Details Krogan NJ, et al. (2006) BNA5 HXK1 TRM8 TRM82
    View Details Qiu et al. (2008) GCD10 GCD14 TRM82

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #22 Asynchronous Prep2-IMAC Phosphopeptide enrichment B1-2 Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TRM82 VBA1 2 Unpublished Fields Lab Data
    View Screen TRM82 ICY1 2 Unpublished Fields Lab Data
    View Screen TRM82 URE2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TRM82 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90] PSI-BLAST 58.522879 Tup1, C-terminal domain
    2 View Details [91..444] PSI-BLAST 77.09691 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.83286470399158 bayes_pls_golite062009
    		• 1.56935945513861 bayes_pls_golite062009
  • RNA binding
    		•  1.50295916950465 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.25687092973217 bayes_pls_golite062009
  • snoRNA binding
    		•  1.22055760394426 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.20712373307552 bayes_pls_golite062009
  • protein binding
    		•  0.969160695900395 bayes_pls_golite062009
  • ligase activity
    		•  0.93058496790047 bayes_pls_golite062009
  • DNA binding
    		•  0.711274653406079 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.441825675082113 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.246495665330495 bayes_pls_golite062009
  • transcription factor activity
    		•  0.243992994917491 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.00335766408304172 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle