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Protein Overview: YRB1

General Information:
Name(s) found: YRB1 / YDR002W [SGD]
Description(s) found:
Found 33 descriptions.
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  • Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 201 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: RNA export from nucleus [IMPLink to PubMed article]
    protein import into nucleus [IMPLink to PubMed article]
    G1/S transition of mitotic cell cycle [IMPLink to PubMed article]
    ubiquitin-dependent protein catabolic process [IMPLink to PubMed article]
    Molecular Function: Ran GTPase binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEDKKPVV DKKEEAAPKP PSSAVFSMFG GKKAEKPETK KDEEDTKEET KKEGDDAPES  60
   61 PDIHFEPVVH LEKVDVKTME EDEEVLYKVR AKLFRFDADA KEWKERGTGD CKFLKNKKTN 120
  121 KVRILMRRDK TLKICANHII APEYTLKPNV GSDRSWVYAC TADIAEGEAE AFTFAIRFGS 180
  181 KENADKFKEE FEKAQEINKK A

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GSP1 GSP2 YRB1
    View Details Ho Y, et al. (2002) CAR1 DPS1 ENP1 GSP1 GSP2 HRP1 KAP104 KGD1 MOG1 MRT4 NAB2 PGM2 RNA1 YDL063C YNL035C YRB1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..201] PSI-BLAST 346.512579 Nuclear pore complex protein Nup358

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.66986263418539 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.64990514605397 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.28276455823937 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.2550809703725 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.25381967078645 bayes_pls_golite062009
  • Ran GTPase binding
    		•  1.07023555877478 bayes_pls_golite062009
  • actin binding
    		•  1.07022589084633 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.745321902095093 bayes_pls_golite062009
  • small GTPase binding
    		•  0.721546282992641 bayes_pls_golite062009
  • GTPase binding
    		•  0.70180064264191 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.324566338715835 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.242570396032937 bayes_pls_golite062009
  • DNA binding
    		•  0.136435190086451 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle