YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: GDH3

General Information:
Name(s) found: GDH3 / YAL062W [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 457 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    soluble fraction [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: glutamate biosynthetic process [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: glutamate dehydrogenase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSEPEFQQA YDEIVSSVED SKIFEKFPQY KKVLPIVSVP ERIIQFRVTW ENDNGEQEVA  60
   61 QGYRVQFNSA KGPYKGGLRF HPSVNLSILK FLGFEQIFKN ALTGLDMGGG KGGLCVDLKG 120
  121 KSDNEIRRIC YAFMRELSRH IGKDTDVPAG DIGVGGREIG YLFGAYRSYK NSWEGVLTGK 180
  181 GLNWGGSLIR PEATGFGLVY YTQAMIDYAT NGKESFEGKR VTISGSGNVA QYAALKVIEL 240
  241 GGIVVSLSDS KGCIISETGI TSEQIHDIAS AKIRFKSLEE IVDEYSTFSE SKMKYVAGAR 300
  301 PWTHVSNVDI ALPCATQNEV SGDEAKALVA SGVKFVAEGA NMGSTPEAIS VFETARSTAT 360
  361 NAKDAVWFGP PKAANLGGVA VSGLEMAQNS QKVTWTAERV DQELKKIMIN CFNDCIQAAQ 420
  421 EYSTEKNTNT LPSLVKGANI ASFVMVADAM LDQGDVF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GDH1 GDH3
    View Details Krogan NJ, et al. (2006) ATP16 CDC60 DHH1 DNF1 GDH3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..188]
    [379..395]
    [439..457]    		 PSI-BLAST 1208.0 Glutamate dehydrogenase
    2 View Details [189..378]
    [396..438]    		 PSI-BLAST 1208.0 Glutamate dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glutamate dehydrogenase (NADP+) activity
    		•  4.50065200228697 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • glutamate dehydrogenase [NAD(P)+] activity
    		•  2.15778057341677 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
    		•  2.00319512154556 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • DNA binding
    		•  1.61355789916908 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.55390653047158 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.48478425318425 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • transcription factor activity
    		•  0.91090893050278 bayes_pls_golite062009
  • structural molecule activity
    		•  0.75267483298133 bayes_pls_golite062009
  • malate dehydrogenase activity
    		•  0.63606663166401 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.0992243118937675 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.0664389065992004 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle