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Protein Overview: Ptp10D-PB

General Information:
Name(s) found: Ptp10D-PB / FBpp0073369 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene Protein tyrosine phosphatase 10D is referred to in FlyBase by the symbol Dmel\Ptp10D (CG1817, FBgn0004370). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11516061..11571371. It has the cytological map location 10D1-10D4. There is experimental evidence that it has the molecular function</span>: phosphoprotein phosphatase activity; protein tyrosine phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: protein amino acid dephosphorylation. 39 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; larval optic neuropil; intersegmental nerve. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1631 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISS][NAS]
    axon [IDA]
    Biological Process: central nervous system development [IGI]
    motor axon guidance [IGI]
    protein amino acid dephosphorylation [IDA][IMP][NAS]
    open tracheal system development [IGI]
    Molecular Function: phosphoprotein phosphatase activity [IDA]
    protein tyrosine phosphatase activity [IDA][ISS][NAS]
    receptor signaling protein tyrosine phosphatase activity [NAS]
    transmembrane receptor protein tyrosine phosphatase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP NNPGLDDGAS  60
   61 YRLDYSPPFG YPEPNTTIAS REIGDEIQFS RALPGTKYNF WLYYTNFTHH DWLTWTVTIT 120
  121 TAPDPPSNLS VQVRSGKNAI ILWSPPTQGS YTAFKIKVLG LSEASSSYNR TFQVNDNTFQ 180
  181 HSVKELTPGA TYQVQAYTIY DGKESVAYTS RNFTTKPNTP GKFIVWFRNE TTLLVLWQPP 240
  241 YPAGIYTHYK VSIEPPDAND SVLYVEKEGE PPGPAQAAFK GLVPGRAYNI SVQTMSEDEI 300
  301 SLPTTAQYRT VPLRPLNVTF DRDFITSNSF RVLWEAPKGI SEFDKYQVSV ATTRRQSTVP 360
  361 RSNEPVAFFD FRDIAEPGKT FNVIVKTVSG KVTSWPATGD VTLRPLPVRN LRSINDDKTN 420
  421 TMIITWEADP ASTQDEYRIV YHELETFNGD TSTLTTDRTR FTLESLLPGR NYSLSVQAVS 480
  481 KKMESNETSI FVVTRPSSPI IEDLKSIRMG LNISWKSDVN SKQEQYEVLY SRNGTSDLRT 540
  541 QKTKESRLVI KNLQPGAGYE LKVFAVSHDL RSEPHAYFQA VYPNPPRNMT IETVRSNSVL 600
  601 VHWSPPESGE FTEYSIRYRT DSEQQWVRLP SVRSTEADIT DMTKGEKYTI QVNTVSFGVE 660
  661 SPVPQEVNTT VPPNPVSNII QLVDSRNITL EWPKPEGRVE SYILKWWPSD NPGRVQTKNV 720
  721 SENKSADDLS TVRVLIGELM PGVQYKFDIQ TTSYGILSGI TSLYPRTMPL IQSDVVVANG 780
  781 EKEDERDTIT LSYTPTPQSS SKFDIYRFSL GDAEIRDKEK LANDTDRKVT FTGLVPGRLY 840
  841 NITVWTVSGG VASLPIQRQD RLYPEPITQL HATNITDTEI SLRWDLPKGE YNDFDIAYLT 900
  901 ADNLLAQNMT TRNEITISDL RPHRNYTFTV VVRSGTESSV LRSSSPLSAS FTTNEAVPGR 960
  961 VERFHPTDVQ PSEINFEWSL PSSEANGVIR QFSIAYTNIN NLTDAGMQDF ESEEAFGVIK1020
 1021 NLKPGETYVF KIQAKTAIGF GPEREYRQTM PILAPPRPAT QVVPTEVYRS SSTIQIRFRK1080
 1081 NYFSDQNGQV RMYTIIVAED DAKNASGLEM PSWLDVQSYS VWLPYQAIDP YYPFENRSVE1140
 1141 DFTIGTENCD NHKIGYCNGP LKSGTTYRVK VRAFTGADKF TDTAYSFPIQ TDQDNTSLIV1200
 1201 AITVPLTIIL VLLVTLLFYK RRRNNCRKTT KDSRANDNMS LPDSVIEQNR PILIKNFAEH1260
 1261 YRLMSADSDF RFSEEFEELK HVGRDQPCTF ADLPCNRPKN RFTNILPYDH SRFKLQPVDD1320
 1321 DEGSDYINAN YVPGHNSPRE FIVTQGPLHS TRDDFWRMCW ESNSRAIVML TRCFEKGREK1380
 1381 CDQYWPNDTV PVFYGDIKVQ ILNDSHYADW VMTEFMLCRG SEQRILRHFH FTTWPDFGVP1440
 1441 NPPQTLVRFV RAFRDRIGAE QRPIVVHCSA GVGRSGTFIT LDRILQQINT SDYVDIFGIV1500
 1501 YAMRKERVWM VQTEQQYICI HQCLLAVLEG KENIVGPARE MHDNEGYEGQ QVQLDENGDV1560
 1561 VATIEGHLSH HDLQQAEAEA IDDENAAILH DDQQPLTSSF TGHHTHMPPT TSMSSFGGGG1620
 1621 GGHTNVDAPD R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] PSI-BLAST 44.69897 No description for 2v5yA was found.
    2 View Details [107..134] PSI-BLAST 17.69897 No description for 1zlgA was found.
    3 View Details [135..771] PSI-BLAST 19.522879 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    4 View Details [772..850] PSI-BLAST 52.09691 FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
    5 View Details [851..956] PSI-BLAST 38.0 Fibronectin, different Fn3 modules
    6 View Details [957..1057] PSI-BLAST 10.30103 No description for 2docA was found.
    7 View Details [1058..1530] PSI-BLAST 78.522879 Tyrosine phosphatase; Tyrosine phoshatase shp-2
    8 View Details [1531..1631] PSI-BLAST 142.0 Crystal structure of the phosphatase domains of human PTP SIGMA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transmembrane receptor activity
    		•  4.21125462030555 bayes_pls_golite062009
  • receptor activity
    		•  4.09185309744435 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • signal transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • cytokine binding
    		•  3.21238178184503 bayes_pls_golite062009
  • growth factor binding
    		•  2.99437744892471 bayes_pls_golite062009
  • cytokine receptor activity
    		•  2.76876397305497 bayes_pls_golite062009
  • binding
    		•  2.69537882298808 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • peptide hormone binding
    		•  1.9205359237864 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.61421027298524 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • kinase activity
    		•  1.57994485110649 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.44501485815273 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • hormone binding
    		•  1.31120662451488 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.18385625326067 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.18385625326067 bayes_pls_golite062009
  • transferase activity
    		•  1.13635878582843 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.745125737480015 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.718355770608923 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • cell surface binding
    		•  0.694105914814106 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • DNA binding
    		•  0.609787884452433 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.60649323348068 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • peptide binding
    		•  0.47885601366674 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • interleukin-2 binding
    		•  0.240383688164201 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.218079243436961 bayes_pls_golite062009
  • structural molecule activity
    		•  0.18965275490219 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.0807821124164596 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0148251912049181 bayes_pls_golite062009
    6 No functions predicted.
    7
    Term Confidence Notes
  • transmembrane receptor protein phosphatase activity
    		•  4.57221148210263 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  4.57221148210263 bayes_pls_golite062009
  • insulin receptor binding
    		•  3.48393497211158 bayes_pls_golite062009
  • protein binding
    		•  3.19631993182765 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • signal transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.88026473691221 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  2.77531895423367 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.76609604594837 bayes_pls_golite062009
  • binding
    		•  2.69791297400248 bayes_pls_golite062009
  • receptor activity
    		•  2.63187639411639 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  2.49496709551693 bayes_pls_golite062009
  • phosphatase activity
    		•  2.39617614358425 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  2.32814368667748 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.22704087268457 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.85015570449703 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • kinase activity
    		•  1.78069536883109 bayes_pls_golite062009
  • protein kinase activity
    		•  1.64363774024605 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.59739467025045 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.53727496158735 bayes_pls_golite062009
  • receptor binding
    		•  1.52843393025918 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.24312972088703 bayes_pls_golite062009
  • transporter activity
    		•  1.21792561830727 bayes_pls_golite062009
  • transferase activity
    		•  1.19152443245584 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  1.1200449509328 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  1.05085928819585 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  1.03150090191995 bayes_pls_golite062009
  • beta-catenin binding
    		•  1.02079992407668 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  1.01632327679132 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.00030784939308 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.950445630788802 bayes_pls_golite062009
  • delta-catenin binding
    		•  0.89195134506409 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.788214946046252 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.73846553033987 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.698379043283481 bayes_pls_golite062009
  • protein complex binding
    		•  0.65988681496356 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.649814096718101 bayes_pls_golite062009
  • DNA binding
    		•  0.580632851213551 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.49044345981587 bayes_pls_golite062009
  • phospholipase binding
    		•  0.43589778800599 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.29798436765753 bayes_pls_golite062009
  • phosphatidylinositol trisphosphate phosphatase activity
    		•  0.28805451968625 bayes_pls_golite062009
  • peptide hormone receptor binding
    		•  0.272080084933271 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.206747304356052 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.200180223985633 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
  • kinase binding
    		•  0.131981353175621 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.0443241110585009 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0308501288849649 bayes_pls_golite062009
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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