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Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate, by a mechanism that requires metal ions. Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate. The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate. null Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. null Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. null

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein tyrosine phosphatase activity
Acc: GO:0004725
Aspect: Molecular Function
Desc: Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Synonyms:
  • PTPase activity
  • phosphotyrosine histone phosphatase activity
  • protein phosphotyrosine phosphatase activity
  • PTP-phosphatase activity
  • tyrosylprotein phosphatase activity
  • [phosphotyrosine]protein phosphatase activity
  • phosphotyrosine phosphatase activity
  • phosphotyrosylprotein phosphatase activity
  • phosphotyrosine protein phosphatase activity
  • PPT-phosphatase activity
  • protein-tyrosine-phosphate phosphohydrolase activity
  • tyrosine O-phosphate phosphatase activity
  • protein-tyrosine-phosphatase activity
  • phosphoprotein phosphatase (phosphotyrosine) activity
Proteins in PDR annotated with:
   This term: 593 [Search]
   Term or descendants: 604 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004725 - protein tyrosine phosphatase activity (interactive image map)
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Created and Maintained by: Michael Riffle