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null Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. The catalysis of phosphate removal from a phosphotyrosine using aspartic acid as a nucleophile in a metal-dependent manner. Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: transmembrane receptor protein tyrosine phosphatase activity
Acc: GO:0005001
Aspect: Molecular Function
Desc:
Proteins in PDR annotated with:
   This term: 36 [Search]
   Term or descendants: 36 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle