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Protein Overview: DLDH_ECOLI

General Information:
Name(s) found: DLDH_ECOLI [Swiss-Prot]
Description(s) found:
Found 13 descriptions.
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  • Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) - Escherichia coli [Swiss-Prot]
    • Organism: Escherichia coli
    Length: 474 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEIKTQVV VLGAGPAGYS AAFRCADLGL ETVIVERYNT LGGVCLNVGC IPSKALLHVA  60
   61 KVIEEAKALA EHGIVFGEPK TDIDKIRTWK EKVINQLTGG LAGMAKGRKV KVVNGLGKFT 120
  121 GANTLEVEGE NGKTVINFDN AIIAAGSRPI QLPFIPHEDP RIWDSTDALE LKEVPERLLV 180
  181 MGGGIIGLEM GTVYHALGSQ IDVVEMFDQV IPAADKDIVK VFTKRISKKF NLMLETKVTA 240
  241 VEAKEDGIYV TMEGKKAPAE PQRYDAVLVA IGRVPNGKNL DAGKAGVEVD DRGFIRVDKQ 300
  301 LRTNVPHIFA IGDIVGQPML AHKGVHEGHV AAEVIAGKKH YFDPKVIPSI AYTEPEVAWV 360
  361 GLTEKEAKEK GISYETATFP WAASGRAIAS DCADGMTKLI FDKESHRVIG GAIVGTNGGE 420
  421 LLGEIGLAIE MGCDAEDIAL TIHAHPTLHE SVGLAAEVFE GSITDLPNPK AKKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..474] PSI-BLAST 83.39794 STRUCTURE OF DIHYDROLIPOAMIDE DEHYDROGENASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate dehydrogenase activity
    		•  6.59152030973708 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  6.01050580930819 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  5.38255966064925 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  5.18991258719053 bayes_pls_golite062009
  • thioredoxin-disulfide reductase activity
    		•  3.42654162439464 bayes_pls_golite062009
  • antioxidant activity
    		•  3.37477730756688 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  3.35142373392777 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.19495080984613 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  3.17769237742078 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.57282017498189 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.50603438449246 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.28982462439281 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.12515648558024 bayes_pls_golite062009
  • catalytic activity
    		•  1.56773888754354 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  1.42994468012845 bayes_pls_golite062009
  • binding
    		•  1.4227698123368 bayes_pls_golite062009
  • protein binding
    		•  1.16738144711505 bayes_pls_golite062009
  • transporter activity
    		•  0.890824576391732 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.706117386114413 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.684108511779641 bayes_pls_golite062009
  • transferase activity
    		•  0.565295320107724 bayes_pls_golite062009
  • electron carrier activity
    		•  0.511623955786613 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.491481205015383 bayes_pls_golite062009
  • coenzyme binding
    		•  0.424849261981 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.26114823844682 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  0.110826254138262 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  0.0160065137614933 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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