YRC Public Data Repository - Protein Structure Prediction

Protein:	DLDH_ECOLI
Organism:	Escherichia coli
Length:	474 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DLDH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91762636, gi\|... - gi\|91762636\|ref\|ZP_01264601.1\| Dihydrolipoyl dehydrogenase [Candidatus Pelagibacter ubique HTCC1002]...	422.0	[0..1]	[465..1]
gi\|71062053, gi\|... - gi\|71082940\|ref\|YP_265659.1\| dihydrolipoyl dehydrogenase [Candidatus Pelagibacter ubique HTCC1062], ...	422.0	[0..1]	[465..1]
gi\|53754287, gi\|... - gi\|54294455\|ref\|YP_126870.1\| lipoamide dehydrogenase [Legionella pneumophila str. Lens], gi\|53754287...	409.0	[0..1]	[474..1]
gi\|53751199, gi\|... - gi\|54297414\|ref\|YP_123783.1\| lipoamide dehydrogenase [Legionella pneumophila str. Paris], gi\|5375119...	409.0	[0..1]	[474..1]
gi\|52841732, gi\|... - gi\|52841732\|ref\|YP_095531.1\| dihydrolipoamide dehydrogenase [Legionella pneumophila subsp. pneumophi...	408.0	[0..1]	[474..6]
gi\|197750879, gi... - gi\|254291792\|ref\|ZP_04962577.1\| pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase [Vibri... gi\|153830353, gi... - gi\|153830353\|ref\|ZP_01983020.1\| pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase [Vibri... gi\|124115514, gi... - gi\|153214088\|ref\|ZP_01949222.1\| pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase [Vibri... gi\|153826874, gi... - gi\|153826874\|ref\|ZP_01979541.1\| pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase [Vibri... gi\|121587629, gi... - gi\|121587629\|ref\|ZP_01677393.1\| pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase [Vibri... gi\|124121667, gi... - gi\|153802802\|ref\|ZP_01957388.1\| pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase [Vibri... gi\|124117718, gi... - gi\|153224278\|ref\|ZP_01954347.1\| pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase [Vibri... gi\|153818407, gi... - gi\|153818407\|ref\|ZP_01971074.1\| pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase [Vibri... gi\|121629358, gi... - gi\|75816041\|ref\|ZP_00746524.1\| COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|229507528, gi... - gi\|229507528\|ref\|ZP_04397033.1\| dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [Vi... gi\|227082533, gi... - gi\|227082533\|ref\|YP_002811084.1\| pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase [Vibr... gi\|254223861, gi... - gi\|75823700\|ref\|ZP_00753185.1\| COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|229332377, gi... - gi\|229528603\|ref\|ZP_04417993.1\| dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [Vi... gi\|229349220, gi... - gi\|229514039\|ref\|ZP_04403501.1\| dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [Vi... tr\|A2PVF2\|A2PVF2... - Dihydrolipoyl dehydrogenase OS=Vibrio cholerae GN=lpdA PE=4 SV=1, Dihydrolipoyl dehydrogenase OS=Vib... gi\|225354706, gi... - gi\|75819337\|ref\|ZP_00749422.1\| COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|146316156, gi... - gi\|75827677\|ref\|ZP_00757112.1\| COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	408.0	[0..1]	[474..1]
DLDH_VIBCH - Dihydrolipoyl dehydrogenase OS=Vibrio cholerae GN=lpd PE=3 SV=1 DLDH_VIBCH - Dihydrolipoyl dehydrogenase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)... gi\|229519412, gi... - gi\|229519412\|ref\|ZP_04408855.1\| dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [Vi... gi\|229352241, gi... - gi\|229512276\|ref\|ZP_04401755.1\| dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [Vi... gi\|229337977, gi... - gi\|229524396\|ref\|ZP_04413801.1\| dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [Vi... gi\|229369689, gi... - gi\|229607034\|ref\|YP_002877682.1\| dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [V... gi\|254849534, gi... - gi\|75829620\|ref\|ZP_00758917.1\| COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	407.0	[0..1]	[474..1]
gi\|82775522, gi\|... - gi\|82775522\|ref\|YP_401869.1\| dihydrolipoamide dehydrogenase [Shigella dysenteriae Sd197], gi\|8123967...	406.0	[0..1]	[474..1]
gi\|75511991, gi\|... - gi\|75511991\|ref\|ZP_00734586.1\| COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|124499105, gi... - gi\|124530578\|ref\|ZP_01701181.1\| dihydrolipoamide dehydrogenase [Escherichia coli B], gi\|124499105\|gb... gi\|170021530, gi... - gi\|170021530\|ref\|YP_001726484.1\| dihydrolipoamide dehydrogenase [Escherichia coli ATCC 8739], gi\|169...	405.0	[0..1]	[474..1]
gi\|52425389, gi\|... - gi\|52425389\|ref\|YP_088526.1\| dihydrolipoamide dehydrogenase [Mannheimia succiniciproducens MBEL55E],...	405.0	[0..1]	[474..39]

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Predicted Domain #1

Region A:
Residues: [1-474]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEIKTQVV VLGAGPAGYS AAFRCADLGL ETVIVERYNT LGGVCLNVGC IPSKALLHVA  60
   61 KVIEEAKALA EHGIVFGEPK TDIDKIRTWK EKVINQLTGG LAGMAKGRKV KVVNGLGKFT 120
  121 GANTLEVEGE NGKTVINFDN AIIAAGSRPI QLPFIPHEDP RIWDSTDALE LKEVPERLLV 180
  181 MGGGIIGLEM GTVYHALGSQ IDVVEMFDQV IPAADKDIVK VFTKRISKKF NLMLETKVTA 240
  241 VEAKEDGIYV TMEGKKAPAE PQRYDAVLVA IGRVPNGKNL DAGKAGVEVD DRGFIRVDKQ 300
  301 LRTNVPHIFA IGDIVGQPML AHKGVHEGHV AAEVIAGKKH YFDPKVIPSI AYTEPEVAWV 360
  361 GLTEKEAKEK GISYETATFP WAASGRAIAS DCADGMTKLI FDKESHRVIG GAIVGTNGGE 420
  421 LLGEIGLAIE MGCDAEDIAL TIHAHPTLHE SVGLAAEVFE GSITDLPNPK AKKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.39794
Match:	1ojtA
Description:	STRUCTURE OF DIHYDROLIPOAMIDE DEHYDROGENASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	6.59152030973708	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	6.01050580930819	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	5.38255966064925	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	5.18991258719053	bayes_pls_golite062009
thioredoxin-disulfide reductase activity	3.42654162439464	bayes_pls_golite062009
antioxidant activity	3.37477730756688	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors	3.35142373392777	bayes_pls_golite062009
oxidoreductase activity	3.19495080984613	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	3.17769237742078	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.57282017498189	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.50603438449246	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.28982462439281	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.12515648558024	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	1.42994468012845	bayes_pls_golite062009
binding	1.4227698123368	bayes_pls_golite062009
protein binding	1.16738144711505	bayes_pls_golite062009
transporter activity	0.890824576391732	bayes_pls_golite062009
transmembrane transporter activity	0.706117386114413	bayes_pls_golite062009
NADPH-adrenodoxin reductase activity	0.684108511779641	bayes_pls_golite062009
transferase activity	0.565295320107724	bayes_pls_golite062009
electron carrier activity	0.511623955786613	bayes_pls_golite062009
substrate-specific transporter activity	0.491481205015383	bayes_pls_golite062009
coenzyme binding	0.424849261981	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.26114823844682	bayes_pls_golite062009
succinate dehydrogenase activity	0.110826254138262	bayes_pls_golite062009
disulfide oxidoreductase activity	0.0160065137614933	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: