YRC Public Data Repository - Protein Structure Prediction

Protein:	SELB_ECOLI
Organism:	Escherichia coli
Length:	614 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SELB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|187732429, gi... - gi\|75179778\|ref\|ZP_00699765.1\| COG3276: Selenocysteine-specific translation elongation factor [Shige...	532.0	[0..1]	[614..1]
gi\|192958123, gi... - gi\|75237532\|ref\|ZP_00721565.1\| COG3276: Selenocysteine-specific translation elongation factor [Esche...	530.0	[0..1]	[614..1]
gi\|110643835, gi... - gi\|110643835\|ref\|YP_671565.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia coli 536... gi\|191170353, gi... - gi\|75242623\|ref\|ZP_00726367.1\| COG3276: Selenocysteine-specific translation elongation factor [Esche... gi\|218429441, gi... - gi\|218691877\|ref\|YP_002400089.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia coli ...	529.0	[0..1]	[614..1]
gi\|81247363, gi\|... - gi\|82545952\|ref\|YP_409899.1\| selenocysteinyl-tRNA-specific translation factor [Shigella boydii Sb227...	529.0	[0..1]	[614..1]
gi\|242379111, gi... - gi\|251786838\|ref\|YP_003001142.1\| hypothetical protein B21_03396 [Escherichia coli BL21], gi\|24237911... gi\|254163517, gi... - gi\|254163517\|ref\|YP_003046625.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia coli ... gi\|254290267, gi... - gi\|254290267\|ref\|YP_003056015.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia coli ... gi\|194435596, gi... - gi\|83588556\|ref\|ZP_00927180.1\| COG3276: Selenocysteine-specific translation elongation factor [Esche...	529.0	[0..1]	[614..1]
gi\|115514994, gi... - gi\|117625870\|ref\|YP_859193.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia coli APE... gi\|226902624, gi... - gi\|237703360\|ref\|ZP_04533841.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia sp. 3_... gi\|91074679, gi\|... - gi\|91213105\|ref\|YP_543091.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia coli UTI8... gi\|218367434, gi... - gi\|218560665\|ref\|YP_002393578.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia coli ...	528.0	[0..1]	[614..1]
gi\|75515946, gi\|... - gi\|75515946\|ref\|ZP_00738064.1\| COG3276: Selenocysteine-specific translation elongation factor [Esche... gi\|157068749, gi... - gi\|75197498\|ref\|ZP_00707568.1\| COG3276: Selenocysteine-specific translation elongation factor [Esche...	528.0	[0..1]	[614..1]
gi\|83571352, gi\|... - gi\|83571352\|ref\|ZP_00922792.1\| COG3276: Selenocysteine-specific translation elongation factor [Shige... gi\|218362920, gi... - gi\|218556152\|ref\|YP_002389065.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia coli ...	528.0	[0..1]	[614..1]
gi\|227883758, gi... - gi\|227883758\|ref\|ZP_04001563.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia coli 8... gi\|26110662, gi\|... - gi\|26250233\|ref\|NP_756273.1\| selenocysteinyl-tRNA-specific translation factor [Escherichia coli CFT0...	528.0	[0..1]	[614..1]
gi\|190904699, gi... - gi\|75231564\|ref\|ZP_00717922.1\| COG3276: Selenocysteine-specific translation elongation factor [Esche... gi\|75211347, gi\|... - gi\|75211347\|ref\|ZP_00711446.1\| COG3276: Selenocysteine-specific translation elongation factor [Esche... gi\|157077689, gi... - gi\|75188355\|ref\|ZP_00701622.1\| COG3276: Selenocysteine-specific translation elongation factor [Esche... gi\|193061782, gi... - gi\|75260120\|ref\|ZP_00731388.1\| COG3276: Selenocysteine-specific translation elongation factor [Esche...	528.0	[0..1]	[614..1]

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Predicted Domain #1

Region A:
Residues: [1-348]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIIATAGHVD HGKTTLLQAI TGVNADRLPE EKKRGMTIDL GYAYWPQPDG RVPGFIDVPG  60
   61 HEKFLSNMLA GVGGIDHALL VVACDDGVMA QTREHLAILQ LTGNPMLTVA LTKADRVDEA 120
  121 RVDEVERQVK EVLREYGFAE AKLFITAATE GRGMDALREH LLQLPEREHA SQHSFRLAID 180
  181 RAFTVKGAGL VVTGTALSGE VKVGDSLWLT GVNKPMRVRA LHAQNQPTET ANAGQRIALN 240
  241 IAGDAEKEQI NRGDWLLADV PPEPFTRVIV ELQTHTPLTQ WQPLHIHHAA SHVTGRVSLL 300
  301 EDNLAELVFD TPLWLADNDR LVLRDISARN TLAGARVVML NPPRRGKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.154902
Match:	1d8tA
Description:	Elongation factor Tu (EF-Tu), domain 2; Elongation factor Tu (EF-Tu); Elongation factor Tu (EF-Tu), N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation elongation factor activity	8.90683166637832	bayes_pls_golite062009
translation factor activity, nucleic acid binding	4.8378725567094	bayes_pls_golite062009
translation regulator activity	4.79814772079421	bayes_pls_golite062009
structural constituent of ribosome	4.56509805974548	bayes_pls_golite062009
structural molecule activity	3.58406348799895	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
translation initiation factor activity	2.7201523708414	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
transporter activity	2.58140740499725	bayes_pls_golite062009
transmembrane transporter activity	2.39695871109024	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
ATPase activity, coupled	2.18396165590908	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
DNA binding	1.7904783386531	bayes_pls_golite062009
transcription regulator activity	1.68903321260301	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
motor activity	1.34881124154297	bayes_pls_golite062009
substrate-specific transporter activity	1.29730375126024	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.906554174337376	bayes_pls_golite062009
transcription factor activity	0.603758349693077	bayes_pls_golite062009
peptidyltransferase activity	0.515626975889911	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
active transmembrane transporter activity	0.434775387083003	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
ion transmembrane transporter activity	0.355466224802969	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	0.353150780751661	bayes_pls_golite062009
microtubule motor activity	0.32730260506261	bayes_pls_golite062009
guanyl nucleotide binding	0.296406132096546	bayes_pls_golite062009
GTP binding	0.295705904888768	bayes_pls_golite062009
primary active transmembrane transporter activity	0.294474570607914	bayes_pls_golite062009
guanyl ribonucleotide binding	0.29028316917561	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.282352478532746	bayes_pls_golite062009
RNA helicase activity	0.2302541318658	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.220608508617331	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.219533217661421	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.219157471322311	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
anion transmembrane transporter activity	0.14873140406343	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.12168417344278	bayes_pls_golite062009
microfilament motor activity	0.10236059675512	bayes_pls_golite062009
RNA binding	0.0693163519626152	bayes_pls_golite062009
protein transporter activity	0.0397092337273124	bayes_pls_golite062009
cation transmembrane transporter activity	0.0254369227200564	bayes_pls_golite062009
peptide transporter activity	0.0135927378126404	bayes_pls_golite062009
signal sequence binding	6.53725193420218E-4	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [349-614]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPEYLQWLAS LARAQSDADA LSVHLERGAV NLADFAWARQ LNGEGMRELL QQPGYIQAGY  60
   61 SLLNAPVAAR WQRKILDTLA TYHEQHRDEP GPGRERLRRM ALPMEDEALV LLLIEKMRES 120
  121 GDIHSHHGWL HLPDHKAGFS EEQQAIWQKA EPLFGDEPWW VRDLAKETGT DEQAMRLTLR 180
  181 QAAQQGIITA IVKDRYYRND RIVEFANMIR DLDQECGSTC AADFRDRLGV GRKLAIQILE 240
  241 YFDRIGFTRR RGNDHLLRDA LLFPEK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.154902
Match:	1lvaA
Description:	C-terminal fragment of elongation factor SelB
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: