YRC Public Data Repository - Protein Structure Prediction

Protein:	SECA_ECOLI
Organism:	Escherichia coli
Length:	901 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SECA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|24111543, gi\|... - gi\|24111543\|ref\|NP_706053.1\| preprotein translocase subunit SecA [Shigella flexneri 2a str. 301], gi... SECA_SHIFL - Protein translocase subunit SecA OS=Shigella flexneri GN=secA PE=3 SV=1 gi\|30039907, gi\|... - gi\|30061665\|ref\|NP_835836.1\| preprotein translocase subunit SecA [Shigella flexneri 2a str. 2457T], ...	1179.0	[0..1]	[901..1]
gi\|227884997, gi... - gi\|227884997\|ref\|ZP_04002802.1\| Sec family type I general secretory pathway protein [Escherichia col... gi\|254791235, gi... - gi\|254791235\|ref\|YP_003076072.1\| preprotein translocase subunit, ATPase [Escherichia coli O157:H7 st... gi\|13359558, gi\|... - gi\|15829356\|ref\|NP_308129.1\| preprotein translocase subunit SecA [Escherichia coli O157:H7 str. Saka... SECA_ECO81 - Protein translocase subunit SecA OS=Escherichia coli O81 (strain ED1a) GN=secA PE=3 SV=1 SECA_ECO7I - Protein translocase subunit SecA OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=secA PE=3 SV=1 SECA_ECOLU - Protein translocase subunit SecA OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=secA PE=... gi\|195938221 - gi\|195938221\|ref\|ZP_03083603.1\| preprotein translocase subunit SecA [Escherichia coli O157:H7 str. E... gi\|208733279, gi... - gi\|208812002\|ref\|ZP_03253331.1\| preprotein translocase, SecA subunit [Escherichia coli O157:H7 str. ... SECA_ECOL6 - Protein translocase subunit SecA OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=s... SECA_ECO5E - Protein translocase subunit SecA OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=secA PE=3 SV=... gi\|209746472, gi... - pir\|\|F85492 preprotein translocase, secretion protein [imported] - Escherichia coli (strain O157:H7,... gi\|217321689, gi... - gi\|217325468\|ref\|ZP_03441552.1\| preprotein translocase, SecA subunit [Escherichia coli O157:H7 str. ... gi\|12512804, gi\|... - gi\|15799782\|ref\|NP_285794.1\| preprotein translocase subunit SecA [Escherichia coli O157:H7 EDL933], ... SECA_ECO57 - Protein translocase subunit SecA OS=Escherichia coli O157:H7 GN=secA PE=3 SV=1 gi\|168755706, gi... - gi\|189357045\|gb\|EDU75464.1\| preprotein translocase, SecA subunit [Escherichia coli O157:H7 str. EC44... SECA_ECOL6 - Protein translocase subunit SecA OS=Escherichia coli O6 GN=secA PE=2 SV=1 gi\|189000465, gi... - gi\|189000465\|gb\|EDU69451.1\| preprotein translocase, SecA subunit [Escherichia coli O157:H7 str. EC40... gi\|189370819, gi... - gi\|189370819\|gb\|EDU89235.1\| preprotein translocase, SecA subunit [Escherichia coli O157:H7 str. EC86...	1178.0	[0..1]	[901..1]
SECA_ECOHS - Protein translocase subunit SecA OS=Escherichia coli O9:H4 (strain HS) GN=secA PE=3 SV=1	1177.0	[0..1]	[901..1]
SECA_ECOUT - Protein translocase subunit SecA OS=Escherichia coli (strain UTI89 / UPEC) GN=secA PE=3 SV=1 SECA_ECOK1 - Protein translocase subunit SecA OS=Escherichia coli O1:K1 / APEC GN=secA PE=3 SV=1 SECA_ECO45 - Protein translocase subunit SecA OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=secA PE=3 SV=1 gi\|226902159, gi... - gi\|237704247\|ref\|ZP_04534728.1\| translocase [Escherichia sp. 3_2_53FAA], gi\|226902159\|gb\|EEH88418.1\|...	1177.0	[0..1]	[901..1]
SECA_ECOL5 - Protein translocase subunit SecA OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=secA PE=3 SV=... gi\|191174246, gi... - gi\|75236901\|ref\|ZP_00720963.1\| COG0653: Preprotein translocase subunit SecA (ATPase, RNA helicase) [...	1177.0	[0..1]	[901..1]
gi\|40866, gi\|147... - gi\|40866\|emb\|CAA38875.1\| SecA protein [Escherichia coli], dbj\|BAB96666.1\| Preprotein translocase Sec...	1176.0	[0..1]	[901..1]
SECA_SHIDS - Protein translocase subunit SecA OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=secA PE=3 SV=1	1173.0	[0..1]	[901..1]
SECA_SALA4 - Protein translocase subunit SecA OS=Salmonella agona (strain SL483) GN=secA PE=3 SV=1 gi\|197261810, gi... - gi\|197261810\|ref\|ZP_03161884.1\| preprotein translocase, SecA subunit [Salmonella enterica subsp. ent... SECA_SALHS - Protein translocase subunit SecA OS=Salmonella heidelberg (strain SL476) GN=secA PE=3 SV=1 SECA_SALTY - Protein translocase subunit SecA OS=Salmonella typhimurium GN=secA PE=2 SV=1 gi\|194458077, gi... - gi\|194471713\|ref\|ZP_03077697.1\| preprotein translocase, SecA subunit [Salmonella enterica subsp. ent... gi\|168464312, gi... - gi\|195632983\|gb\|EDX51437.1\| preprotein translocase, SecA subunit [Salmonella enterica subsp. enteric... SECA_SALNS - Protein translocase subunit SecA OS=Salmonella newport (strain SL254) GN=secA PE=3 SV=1 gi\|168230415, gi... - gi\|205335016\|gb\|EDZ21780.1\| preprotein translocase, SecA subunit [Salmonella enterica subsp. enteric... gi\|205337456, gi... - gi\|205337456\|gb\|EDZ24220.1\| preprotein translocase, SecA subunit [Salmonella enterica subsp. enteric... gi\|205324321, gi... - gi\|205324321\|gb\|EDZ12160.1\| preprotein translocase, SecA subunit [Salmonella enterica subsp. enteric... SECA_SALCH - Protein translocase subunit SecA OS=Salmonella choleraesuis (strain SC-B67) GN=secA PE=3 SV=1 gi\|167990009, gi... - gi\|205331375\|gb\|EDZ18139.1\| preprotein translocase, SecA subunit [Salmonella enterica subsp. enteric... SECA_SALTY - Protein translocase subunit SecA OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=... SECA_SALTY - Protein translocase subunit secA OS=Salmonella typhimurium GN=secA PE=2 SV=1 gi\|238911193 - gi\|238911193\|ref\|ZP_04655030.1\| preprotein translocase subunit SecA [Salmonella enterica subsp. ente... SECA_SALG2 - Protein translocase subunit SecA OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=secA PE=3 ... SECA_SALCH - Protein translocase subunit secA OS=Salmonella choleraesuis GN=secA PE=2 SV=1 SECA_SALPC - Protein translocase subunit SecA OS=Salmonella paratyphi C (strain RKS4594) GN=secA PE=3 SV=1 SECA_SALCH - Protein translocase subunit SecA OS=Salmonella choleraesuis GN=secA PE=2 SV=1 SECA_SALDC - Protein translocase subunit SecA OS=Salmonella dublin (strain CT_02021853) GN=secA PE=3 SV=1 gi\|200389184, gi... - gi\|200389184\|ref\|ZP_03215796.1\| preprotein translocase, SecA subunit [Salmonella enterica subsp. ent... lcl\|NC_016856.1_... - [gene=secA] [protein=preprotein translocase subunit SecA] [protein_id=YP_005235795.1] [location=1594...	1170.0	[0..1]	[900..1]
gi\|213051854 - gi\|213051854\|ref\|ZP_03344732.1\| preprotein translocase subunit SecA [Salmonella enterica subsp. ente... gi\|213427401 - gi\|213427401\|ref\|ZP_03360151.1\| preprotein translocase subunit SecA [Salmonella enterica subsp. ente... gi\|213648255 - gi\|213648255\|ref\|ZP_03378308.1\| preprotein translocase subunit SecA [Salmonella enterica subsp. ente... gi\|29140681, gi\|... - gi\|29140681\|ref\|NP_804023.1\| preprotein translocase subunit SecA [Salmonella enterica subsp. enteric... gi\|16759131 - gi\|16759131\|ref\|NP_454748.1\| preprotein translocase subunit SecA [Salmonella enterica subsp. enteric... SECA_SALTI - Protein translocase subunit SecA OS=Salmonella typhi GN=secA PE=3 SV=1 SECA_SALTI - Protein translocase subunit secA OS=Salmonella typhi GN=secA PE=2 SV=1 gi\|213999312 - gi\|213999312\|ref\|ZP_03410047.1\| preprotein translocase subunit SecA [Salmonella enterica subsp. ente...	1169.0	[0..1]	[900..1]
SECA_SALPK - Protein translocase subunit SecA OS=Salmonella paratyphi A (strain AKU_12601) GN=secA PE=3 SV=1 SECA_SALPA - Protein translocase subunit SecA OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=secA PE=3 ... SECA_SALPA - Protein translocase subunit SecA OS=Salmonella paratyphi A GN=secA PE=2 SV=1	1168.0	[0..1]	[900..1]

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Predicted Domain #1

Region A:
Residues: [1-901]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIKLLTKVF GSRNDRTLRR MRKVVNIINA MEPEMEKLSD EELKGKTAEF RARLEKGEVL  60
   61 ENLIPEAFAV VREASKRVFG MRHFDVQLLG GMVLNERCIA EMRTGEGKTL TATLPAYLNA 120
  121 LTGKGVHVVT VNDYLAQRDA ENNRPLFEFL GLTVGINLPG MPAPAKREAY AADITYGTNN 180
  181 EYGFDYLRDN MAFSPEERVQ RKLHYALVDE VDSILIDEAR TPLIISGPAE DSSEMYKRVN 240
  241 KIIPHLIRQE KEDSETFQGE GHFSVDEKSR QVNLTERGLV LIEELLVKEG IMDEGESLYS 300
  301 PANIMLMHHV TAALRAHALF TRDVDYIVKD GEVIIVDEHT GRTMQGRRWS DGLHQAVEAK 360
  361 EGVQIQNENQ TLASITFQNY FRLYEKLAGM TGTADTEAFE FSSIYKLDTV VVPTNRPMIR 420
  421 KDLPDLVYMT EAEKIQAIIE DIKERTAKGQ PVLVGTISIE KSELVSNELT KAGIKHNVLN 480
  481 AKFHANEAAI VAQAGYPAAV TIATNMAGRG TDIVLGGSWQ AEVAALENPT AEQIEKIKAD 540
  541 WQVRHDAVLE AGGLHIIGTE RHESRRIDNQ LRGRSGRQGD AGSSRFYLSM EDALMRIFAS 600
  601 DRVSGMMRKL GMKPGEAIEH PWVTKAIANA QRKVESRNFD IRKQLLEYDD VANDQRRAIY 660
  661 SQRNELLDVS DVSETINSIR EDVFKATIDA YIPPQSLEEM WDIPGLQERL KNDFDLDLPI 720
  721 AEWLDKEPEL HEETLRERIL AQSIEVYQRK EEVVGAEMMR HFEKGVMLQT LDSLWKEHLA 780
  781 AMDYLRQGIH LRGYAQKDPK QEYKRESFSM FAAMLESLKY EVISTLSKVQ VRMPEEVEEL 840
  841 EQQRRMEAER LAQMQQLSHQ DDDSAAAAAL AAQTGERKVG RNDPCPCGSG KKYKQCHGRL 900
  901 Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1tf2A
Description:	Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	4.96050219760327	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.56325751172863	bayes_pls_golite062009
binding	1.55526868300981	bayes_pls_golite062009
ion transmembrane transporter activity	0.977237423302079	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
peptide-transporting ATPase activity	0.911425383309011	bayes_pls_golite062009
motor activity	0.87979065815418	bayes_pls_golite062009
GTPase activity	0.83849854735032	bayes_pls_golite062009
peptide transporter activity	0.73541731084591	bayes_pls_golite062009
protein binding	0.569246647740442	bayes_pls_golite062009
cation transmembrane transporter activity	0.557919489256916	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	0.48775834126327	bayes_pls_golite062009
catalytic activity	0.458437698837681	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
guanyl nucleotide binding	0.373350189511011	bayes_pls_golite062009
guanyl ribonucleotide binding	0.363151049799385	bayes_pls_golite062009
GTP binding	0.343113158179248	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.25714006331445	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	0.213018989352421	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.123304946374679	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: