YRC Public Data Repository - Protein Structure Prediction

Protein:	PURK_ECOLI
Organism:	Escherichia coli
Length:	355 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PURK_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91774335, gi\|... - gi\|91774335\|ref\|YP_567027.1\| pyruvate carboxylase subunit A [Methanococcoides burtonii DSM 6242], gi...	355.0	[0..2]	[353..3]
gi\|109043037 - gi\|109043037\|ref\|XP_001096717.1\| PREDICTED: similar to methylcrotonoyl-Coenzyme A carboxylase 1 (alp...	355.0	[0..1]	[354..121]
gi\|114590613 - gi\|114590613\|ref\|XP_516898.2\| PREDICTED: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) [Pan trogl...	355.0	[0..1]	[354..180]
gi\|83636689, gi\|... - gi\|83648646\|ref\|YP_437081.1\| acetyl-CoA carboxylase, biotin carboxylase [Hahella chejuensis KCTC 239...	354.0	[0..1]	[354..2]
gi\|46119399, gi\|... - gi\|67923410\|ref\|ZP_00516889.1\| Acetyl-CoA carboxylase, biotin carboxylase [Crocosphaera watsonii WH ...	354.0	[0..3]	[353..6]
gi\|86608860, gi\|... - gi\|86608860\|ref\|YP_477622.1\| acetyl-CoA carboxylase biotin carboxylase subunit [Synechococcus sp. JA... gi\|86608860 - gi\|86608860\|ref\|YP_477622.1\| acetyl-CoA carboxylase, biotin carboxylase [Cyanobacteria bacterium Yel...	352.0	[0..1]	[354..4]
gi\|35212579, gi\|... - gi\|37521581\|ref\|NP_924958.1\| acetyl-CoA carboxylase biotin carboxylase subunit [Gloeobacter violaceu...	352.0	[0..2]	[351..5]
gi\|62089054 - gi\|62089054\|dbj\|BAD92974.1\| methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) variant [Homo sapiens]	351.0	[0..1]	[354..65]
gi\|186685989, gi... - gi\|23129462\|ref\|ZP_00111289.1\| COG0439: Biotin carboxylase [Nostoc punctiforme PCC 73102], gi\|186685...	350.0	[0..3]	[354..5]

Back

Predicted Domain #1

Region A:
Residues: [1-355]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQVCVLGNG QLGRMLRQAG EPLGIAVWPV GLDAEPAAVP FQQSVITAEI ERWPETALTR  60
   61 ELARHPAFVN RDVFPIIADR LTQKQLFDKL HLPTAPWQLL AERSEWPAVF DRLGELAIVK 120
  121 RRTGGYDGRG QWRLRANETE QLPAECYGEC IVEQGINFSG EVSLVGARGF DGSTVFYPLT 180
  181 HNLHQDGILR TSVAFPQANA QQQAQAEEML SAIMQELGYV GVMAMECFVT PQGLLINELA 240
  241 PRVHNSGHWT QNGASISQFE LHLRAITDLP LPQPVVNNPS VMINLIGSDV NYDWLKLPLV 300
  301 HLHWYDKEVR PGRKVGHLNL TDSDTSRLTA TLEALIPLLP PEYASGVIWA QSKFG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.69897
Match:	1b6rA
Description:	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosylaminoimidazole carboxylase activity	8.30252180826751	bayes_pls_golite062009
carboxy-lyase activity	4.46679646341684	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.99262646198755	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	2.80055235272563	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	2.72231827182887	bayes_pls_golite062009
phosphoribosylamine-glycine ligase activity	1.37477732460326	bayes_pls_golite062009
ligase activity	1.13657217096051	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1.11645327303429	bayes_pls_golite062009
catalytic activity	1.08688404807699	bayes_pls_golite062009
acid-amino acid ligase activity	0.730894973410499	bayes_pls_golite062009
binding	0.552939485505354	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: