YRC Public Data Repository - Protein Structure Prediction

Protein:	KAD_ECOLI
Organism:	Escherichia coli
Length:	214 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KAD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|145638740, gi... - gi\|145638740\|ref\|ZP_01794349.1\| adenylate kinase [Haemophilus influenzae PittII], gi\|145272335\|gb\|ED... KAD_HAEIG - Adenylate kinase OS=Haemophilus influenzae (strain PittGG) GN=adk PE=3 SV=1 gi\|145628705, gi... - gi\|145628705\|ref\|ZP_01784505.1\| adenylate kinase [Haemophilus influenzae 22.1-21], gi\|144979175\|gb\|E... gi\|145636382, gi... - gi\|145636382\|ref\|ZP_01792051.1\| adenylate kinase [Haemophilus influenzae PittHH], gi\|145270547\|gb\|ED... gi\|53733217 - gi\|53733217\|ref\|ZP_00156188.2\| COG0563: Adenylate kinase and related kinases [Haemophilus influenzae... KAD_HAEI8 - Adenylate kinase OS=Haemophilus influenzae (strain 86-028NP) GN=adk PE=3 SV=1 KAD_HAEIN - Adenylate kinase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=adk PE=3 S... KAD_HAEIN - Adenylate kinase OS=Haemophilus influenzae GN=adk PE=3 SV=2 gi\|229812809, gi... - gi\|229844560\|ref\|ZP_04464700.1\| adenylate kinase [Haemophilus influenzae 6P18H1], gi\|229812809\|gb\|EE...	227.0	[0..1]	[214..1]
gi\|43591 - gi\|43591\|emb\|CAA40570.1\| adenylate kinase [Haemophilus influenzae] gi\|53732959 - gi\|53732959\|ref\|ZP_00155356.2\| COG0563: Adenylate kinase and related kinases [Haemophilus influenzae... gi\|145274886, gi... - gi\|145640300\|ref\|ZP_01795884.1\| adenylate kinase [Haemophilus influenzae R3021], gi\|145274886\|gb\|EDK... gi\|145640300 - gi\|145640300\|ref\|ZP_01795884.1\| adenylate kinase [Haemophilus influenzae R3021]	227.0	[0..1]	[214..1]
KAD_MANSM - Adenylate kinase OS=Mannheimia succiniciproducens (strain MBEL55E) GN=adk PE=3 SV=1	226.0	[0..1]	[214..5]
gi\|1773156 - gi\|1773156\|gb\|AAB40228.1\| adenylate kinase [Escherichia coli] gi\|192929229, gi... - gi\|193064200\|ref\|ZP_03045284.1\| adenylate kinase [Escherichia coli E22], gi\|192929229\|gb\|EDV82839.1\|...	224.0	[0..1]	[214..20]
gi\|227838599, gi... - gi\|227884513\|ref\|ZP_04002318.1\| adenylate kinase [Escherichia coli 83972], gi\|227838599\|gb\|EEJ49065.... gi\|26106887, gi\|... - gi\|26246489\|ref\|NP_752528.1\| adenylate kinase [Escherichia coli CFT073], gi\|26106887\|gb\|AAN79072.1\|A...	223.0	[0..1]	[214..21]
KAD_SHEAM - Adenylate kinase OS=Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) GN=adk PE=3 SV=1	223.0	[0..1]	[213..1]
KAD_PSEA6 - Adenylate kinase OS=Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) GN=adk PE=3 SV=1	221.0	[0..1]	[214..1]
gi\|117622731, gi... - gi\|117622731\|ref\|YP_851644.1\| adenylate kinase [Escherichia coli APEC O1], gi\|115511855\|gb\|ABI99929....	221.0	[0..1]	[214..20]
gi\|91071122, gi\|... - gi\|91209548\|ref\|YP_539534.1\| adenylate kinase [Escherichia coli UTI89], gi\|91071122\|gb\|ABE06003.1\| a... gi\|237707528, gi... - gi\|237707528\|ref\|ZP_04538009.1\| adenylate kinase [Escherichia sp. 3_2_53FAA], gi\|226898738\|gb\|EEH849...	221.0	[0..1]	[214..21]
KAD_ACTSZ - Adenylate kinase OS=Actinobacillus succinogenes (strain ATCC 55618 / 130Z) GN=adk PE=3 SV=1	221.0	[0..1]	[214..1]

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Predicted Domain #1

Region A:
Residues: [1-214]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIILLGAPG AGKGTQAQFI MEKYGIPQIS TGDMLRAAVK SGSELGKQAK DIMDAGKLVT  60
   61 DELVIALVKE RIAQEDCRNG FLLDGFPRTI PQADAMKEAG INVDYVLEFD VPDELIVDRI 120
  121 VGRRVHAPSG RVYHVKFNPP KVEGKDDVTG EELTTRKDDQ EETVRKRLVE YHQMTAPLIG 180
  181 YYSKEAEAGN TKYAKVDGTK PVAEVRADLE KILG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.0
Match:	1akeA
Description:	Adenylate kinase; Microbial and mitochondrial ADK, insert "zinc finger" domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	5.63633783771436	bayes_pls_golite062009
nucleotide kinase activity	4.87013305162694	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	4.71956130169341	bayes_pls_golite062009
adenylate kinase activity	3.67594732794865	bayes_pls_golite062009
transporter activity	3.06347241703095	bayes_pls_golite062009
transmembrane transporter activity	2.92178249124988	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.72471277217637	bayes_pls_golite062009
pyrophosphatase activity	2.65178178494722	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.6324074638534	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.62930532133361	bayes_pls_golite062009
active transmembrane transporter activity	2.47371672314006	bayes_pls_golite062009
primary active transmembrane transporter activity	2.36656376979386	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.36628513972722	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.33101326378731	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.32956222649229	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.32729839766053	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	2.29455092461489	bayes_pls_golite062009
ATPase activity	2.23432662573776	bayes_pls_golite062009
ATPase activity, coupled	2.22021172695288	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
DNA binding	1.7904783386531	bayes_pls_golite062009
transcription regulator activity	1.68903321260301	bayes_pls_golite062009
substrate-specific transporter activity	1.62497652645669	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.39044805677656	bayes_pls_golite062009
hydrolase activity	1.32740066346416	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.28936854749141	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.27520023113176	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
guanylate kinase activity	0.98934362137863	bayes_pls_golite062009
purine nucleotide binding	0.912853112793192	bayes_pls_golite062009
nucleotide binding	0.905342574142397	bayes_pls_golite062009
purine ribonucleotide binding	0.904115761720541	bayes_pls_golite062009
ribonucleotide binding	0.904053997411779	bayes_pls_golite062009
GTPase activity	0.83849854735032	bayes_pls_golite062009
structural constituent of ribosome	0.738234102557832	bayes_pls_golite062009
protein transporter activity	0.712797684532763	bayes_pls_golite062009
motor activity	0.70874549510465	bayes_pls_golite062009
ion transmembrane transporter activity	0.678463776360409	bayes_pls_golite062009
transcription factor activity	0.603758349693077	bayes_pls_golite062009
CTP synthase activity	0.554689818807922	bayes_pls_golite062009
microtubule motor activity	0.48522137429998	bayes_pls_golite062009
ATP binding	0.38929752840764	bayes_pls_golite062009
adenyl ribonucleotide binding	0.364108656344062	bayes_pls_golite062009
adenyl nucleotide binding	0.356069365520539	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
cation transmembrane transporter activity	0.256834704602307	bayes_pls_golite062009
formate-tetrahydrofolate ligase activity	0.21533099279384	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
structural molecule activity	0.0558641287316701	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: