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Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: formate-tetrahydrofolate ligase activity
Acc: GO:0004329
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
Synonyms:
  • 10-formyl-THF synthetase activity
  • tetrahydrofolic formylase activity
  • 10-formyltetrahydrofolate synthetase activity
  • tetrahydrofolate formylase activity
  • formyltetrahydrofolate synthetase activity
  • formate:tetrahydrofolate ligase (ADP-forming)
Proteins in PDR annotated with:
   This term: 23 [Search]
   Term or descendants: 23 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004329 - formate-tetrahydrofolate ligase activity (interactive image map)
YRC Informatics Platform - Version 3.0
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