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View Structure Prediction Details

Protein: let-754
Organism: Caenorhabditis elegans
Length: 251 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for let-754.

Description E-value Query
Range		 Subject
Range
KAD_CARHZ - Adenylate kinase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) GN=a...
 232.0 [0..27] [240..1]

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Predicted Domain #1
Region A:
Residues: [1-251] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVPKTQQSA QPATQSAGPT ETLARGIRAI FIGPPGSGKG TQAPAFAQKY FSCHLATGDL  60
   61 LRAEVASGSE FGKELKATMD AGKLVSDEVV CKLIEQKLEK PECKYGFILD GFPRTSGQAE 120
  121 KLDEILERRK TPLDTVVEFN IADDLLVRRI TGRLFHIASG RSYHLEFKPP KVPMKDDLTG 180
  181 EPLIRRSDDN EETLRKRLVQ YHQMTVPLVD YYKKHGVHVA VDAAKPMTDV KAHIDQVFAK 240
  241 FTQKKERVSF V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.154902
Match: 1ak2A
Description: ADENYLATE KINASE ISOENZYME-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleobase, nucleoside, nucleotide kinase activity 5.63633783771436 bayes_pls_golite062009
nucleotide kinase activity 4.87013305162694 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 4.82340609517643 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 4.71956130169341 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 3.99447661719154 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 3.87925071606336 bayes_pls_golite062009
adenylate kinase activity 3.67594732794865 bayes_pls_golite062009
transporter activity 3.06347241703095 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 3.06199686145935 bayes_pls_golite062009
transmembrane transporter activity 2.92178249124988 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.72471277217637 bayes_pls_golite062009
pyrophosphatase activity 2.65178178494722 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.6324074638534 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.62930532133361 bayes_pls_golite062009
active transmembrane transporter activity 2.47371672314006 bayes_pls_golite062009
primary active transmembrane transporter activity 2.36656376979386 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.36628513972722 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.33101326378731 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.32956222649229 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.32729839766053 bayes_pls_golite062009
ATPase activity 2.23432662573776 bayes_pls_golite062009
ATPase activity, coupled 2.22021172695288 bayes_pls_golite062009
nucleic acid binding 2.11222585187695 bayes_pls_golite062009
DNA binding 1.7904783386531 bayes_pls_golite062009
transcription regulator activity 1.68903321260301 bayes_pls_golite062009
substrate-specific transporter activity 1.62497652645669 bayes_pls_golite062009
ribonucleotide binding 1.53142082854758 bayes_pls_golite062009
purine nucleotide binding 1.52938239070386 bayes_pls_golite062009
purine ribonucleotide binding 1.52887308780164 bayes_pls_golite062009
nucleotide binding 1.52746968836881 bayes_pls_golite062009
hydrolase activity 1.32740066346416 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.28936854749141 bayes_pls_golite062009
ATP binding 1.23942044024113 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
adenyl ribonucleotide binding 1.21044170258803 bayes_pls_golite062009
adenyl nucleotide binding 1.19481945569892 bayes_pls_golite062009
kinase activity 1.11120928120082 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
guanylate kinase activity 0.98934362137863 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.938652092720669 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.908046791062776 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
structural constituent of ribosome 0.738234102557832 bayes_pls_golite062009
protein transporter activity 0.712797684532763 bayes_pls_golite062009
motor activity 0.70874549510465 bayes_pls_golite062009
ion transmembrane transporter activity 0.678463776360409 bayes_pls_golite062009
transcription factor activity 0.603758349693077 bayes_pls_golite062009
CTP synthase activity 0.554689818807922 bayes_pls_golite062009
microtubule motor activity 0.48522137429998 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.421921195209539 bayes_pls_golite062009
protein kinase activity 0.351308564667977 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
cation transmembrane transporter activity 0.256834704602307 bayes_pls_golite062009
formate-tetrahydrofolate ligase activity 0.21533099279384 bayes_pls_golite062009
transferase activity 0.175269600441384 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
structural molecule activity 0.0558641287316701 bayes_pls_golite062009
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