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View Structure Prediction Details

Protein: par-4
Organism: Caenorhabditis elegans
Length: 617 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for par-4.

Description E-value Query
Range
Subject
Range
gi|60826237 - gi|60826237|gb|AAX36750.1| protein kinase C alpha [synthetic construct]
382.0 [0..16] [512..172]

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Predicted Domain #1
Region A:
Residues: [1-514]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAPSTSSGA QSKLLMPGDD EADEDHQNRG DPNLQQKQKI QLNVDPDYDD DEDDDCFIDG  60
   61 CEASAPITRE LVDGAIERRS KDRNVKMSIG VYDEYDDDDD DEEETEEDQR RRFVEGIRNI 120
  121 RHKQQESFDL EEHPIPVESE AMRQFINQQV NNAMMFNQDN SEFQHIEFEP IVKQKGPKII 180
  181 EGYMWGGQIG TGSYGKVKEC IDMYTLTRRA VKIMKYDKLR KITNGWENIR SEMSILRRMN 240
  241 HRNVIKLIEI FNIPAKGKVY MVFEYCIGSV QQLLDMEPAR RLTIGESHAI FIELCQGLNY 300
  301 LHSKRVSHKD IKPGNLLVSI DFTVKICDFG VAEQINLFQR DGRCTKVNGT PKFQPPECIY 360
  361 GNHDFFDGYK ADMWSAGVTL YNLVSGKYPF EKPVLLKLYE CIGTEPLQMP TNVQLTKDLQ 420
  421 DLLTKLLEKD FNERPTCLET MIHPWFLSTF PEDQGLGRIM ERMRTGDRPL TMLSSMTALY 480
  481 DGITPEDELI IEDNLGIIQQ ILPINLTSEA VLER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.09691
Match: 2ptkA
Description: CHICKEN SRC TYROSINE KINASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.24008660655062 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 4.93501454706421 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.63692708178478 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.26787750561728 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
telethonin binding 1.59285057739948 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.20800936400261 bayes_pls_golite062009
molecular adaptor activity 1.17345244671832 bayes_pls_golite062009
receptor signaling protein activity 1.13658159660305 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.08185110129009 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
alpha-actinin binding 0.713064190387634 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transporter activity 0.553953601841147 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
transmembrane transporter activity 0.37676337669549 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
MAP kinase activity 0.08504542461349 bayes_pls_golite062009
substrate-specific transporter activity 0.0611721261859464 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [515-617]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSFPGFKFLE AKPGDGPDGV EGSEDSAAPL GPQRRPSSRS MPTCAPPGPA AGNAQNSTAE  60
   61 NGAETDGVAS ASDPPPTAAP GAPPRRRKRN FFSCIFRSRT DSA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle