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View Structure Prediction Details

Protein: flr-4
Organism: Caenorhabditis elegans
Length: 570 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for flr-4.

Description E-value Query
Range
Subject
Range
gi|157771912 - gi|157771912|ref|XP_001677776.1| Hypothetical protein CBG07634 [Caenorhabditis briggsae AF16]
gi|187033269, gi... - gi|39596642|emb|CAE63261.1| Hypothetical protein CBG07634 [Caenorhabditis briggsae], gi|187033269|em...
378.0 [0..11] [560..1]

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Predicted Domain #1
Region A:
Residues: [1-440]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPINYNRNAV ELKLSSQLLQ WLDQRLPLGD PMRIPSIDSY KYIQDLGKGR FGTVCKFSNG  60
   61 NTFETVKKVD LTIFNHWTQS ETKVSNRLDT FLYEFRHLHK VTNDNNRIVN FLGIYADSNQ 120
  121 MYIMSEYLPR GSVKDLLVKE TLGEDTAIKY LMETVEALDY LHNLSPPVIH RDIKAANLLI 180
  181 TSNDSIKLAN FGLVRDLAVD GFGIAIASEI TLDFRATLLY VAPEVLSSAL GPGNRNAYEL 240
  241 PADIWALGCT FIEMLLKRPP HFEYFGHIDE IPKVLLGYAK SEDGKVLPYT SEVLVPSSSN 300
  301 CVQKIVDLVF IKSPEHRPNT HKLRIQIKKI LDDDSESEEE TDISHPISNS NTDSSTAISH 360
  361 NHSNDRKVGR AGTCLPIESM EYAAVRKELK KRSKPKSNNI MQIFVASGYY LSRILYFLNI 420
  421 LTRSICYLLL FLSLGITALG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.30103
Match: 2jdoA
Description: No description for 2jdoA was found.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
acetylcholine receptor activator activity 3.99271404703989 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
structural molecule activity 3.82327979736517 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.92237954011375 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.90191213374396 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
protein tyrosine kinase activity 2.36057410204148 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
transmembrane receptor activity 2.18678745551825 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
receptor activity 1.9592549430179 bayes_pls_golite062009
molecular transducer activity 1.95775692939268 bayes_pls_golite062009
signal transducer activity 1.95775692939268 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.94085498993561 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
small conjugating protein ligase activity 1.74206248731815 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
receptor signaling protein activity 1.63027742934354 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.6084489855403 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
ErbB-3 class receptor binding 1.34841233233438 bayes_pls_golite062009
ErbB-2 class receptor binding 1.33825339298024 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
acid-amino acid ligase activity 1.2266791546014 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
growth factor binding 1.07015638650842 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.00828610859671 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
insulin receptor substrate binding 0.98689034826741 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.6401520754249 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.6401520754249 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
substrate-specific transporter activity 0.451090007290896 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
structural constituent of muscle 0.399773397398032 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.30681867974635 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
RNA binding 0.245748631571068 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.205652638854091 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009
brain-derived neurotrophic factor binding 0.00315481858218991 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [441-570]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFLLISYFVV RFVRYLIAIN CNCDLMQPQY LIISGILIVL MFALLFSCCM VALGEYKFRM  60
   61 ANQTLDGSKF YLPRPQKSAV LCGITVITGK EDAKDTAQNM EEEIHLTPSV RRNHDDYYYD 120
  121 ESSGPANEEN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle