YRC Public Data Repository - Protein Structure Prediction

Protein:	CE17524
Organism:	Caenorhabditis elegans
Length:	262 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE17524.

Description	E-value	Query Range	Subject Range
gi\|210226 - gi\|210226\|gb\|AAA42573.1\| tyrosine-specific protein kinase	204.0	[0..4]	[261..141]
gi\|148726500, gi... - gi\|47086483\|ref\|NP_997946.1\| Yes-related kinase [Danio rerio], gi\|27372075\|gb\|AAN87886.1\| Yes-relaye...	202.0	[0..4]	[261..133]
gi\|18146654 - gi\|18146654\|dbj\|BAB82424.1\| protein tyrosine kinase [Ephydatia fluviatilis]	201.0	[0..3]	[260..113]
SRC_AVISS - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S1) GN=V-SRC PE=3 SV...	201.0	[0..4]	[261..141]
gi\|210265 - gi\|210265\|gb\|AAA42583.1\| p66-src protein gi\|394713 - gi\|394713\|emb\|CAA36156.1\| src protein [Avian sarcoma virus] SRC_AVIS2 - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain PR2257) GN=V-SRC PE=...	200.0	[0..4]	[261..141]
SRC_CHICK - Proto-oncogene tyrosine-protein kinase Src OS=Gallus gallus GN=SRC PE=1 SV=4	200.0	[0..4]	[261..141]
SRC_RSVSA - Tyrosine-protein kinase transforming protein Src OS=Avian leukosis virus RSA GN=V-SRC PE=1 SV=5 gi\|210189 - gi\|210189\|gb\|AAA42565.1\| src-p60 phosphoprotein SRC_AVISR - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain rASV1441) GN=V-SRC P...	200.0	[0..4]	[261..141]
SRC_AVIST - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S2) GN=V-SRC PE=3 SV...	200.0	[0..4]	[261..141]

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Predicted Domain #1

Region A:
Residues: [1-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDKDLLHQK YYHGLLPRED IQEMLNKPGQ FLLRTSEPVK GEKRQFVLSV VGEKKTSANH  60
   61 FVVRESDHKV YVDKIGFPTI IELVNHYVST KESFSTKDGT VKAVLKQAVE RQKWELYHED 120
  121 VELTKKLGEG AFGEVWKGKL LKILDANHQP VLVAVKTAKL ESMTKEQIKE IMREARLMRN 180
  181 LDHINVVKFF GVAAGTEPLY VIMELADGGA LDSALGKLHF PMIKKYELIY QAANGLAYIH 240
  241 EKNLMHRDVA ARNCLYGGGQ VL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.39794
Match:	2ptkA
Description:	CHICKEN SRC TYROSINE KINASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	3.19631993182765	bayes_pls_golite062009
binding	3.12724619324809	bayes_pls_golite062009
ubiquitin-protein ligase activity	2.53071837898279	bayes_pls_golite062009
molecular transducer activity	2.5284324342567	bayes_pls_golite062009
signal transducer activity	2.5284324342567	bayes_pls_golite062009
small conjugating protein ligase activity	2.35007226898734	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.85015570449703	bayes_pls_golite062009
kinase activity	1.78069536883109	bayes_pls_golite062009
acid-amino acid ligase activity	1.60687631865164	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.59739467025045	bayes_pls_golite062009
transcription regulator activity	1.53001448362299	bayes_pls_golite062009
protein kinase activity	1.4654611643382	bayes_pls_golite062009
nucleic acid binding	1.42004923513043	bayes_pls_golite062009
insulin receptor binding	1.37477835792995	bayes_pls_golite062009
molecular adaptor activity	1.33740973673697	bayes_pls_golite062009
DNA binding	1.28564307823723	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.2323381312171	bayes_pls_golite062009
transferase activity	1.19152443245584	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
cytoskeletal protein binding	0.83493091348808	bayes_pls_golite062009
actin filament binding	0.75424908168927	bayes_pls_golite062009
transcription factor activity	0.679405046366591	bayes_pls_golite062009
protein phosphorylated amino acid binding	0.649814096718101	bayes_pls_golite062009
receptor binding	0.460399756639525	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.452350351194157	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
SH3 domain binding	0.17463828168007	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.169458153875562	bayes_pls_golite062009
phosphoprotein binding	0.16798254471727	bayes_pls_golite062009
kinase regulator activity	0.10704587503284	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: