YRC Public Data Repository - Protein Structure Prediction

Protein:	fft2
Organism:	Schizosaccharomyces pombe
Length:	1284 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fft2.

Description	E-value	Query Range	Subject Range
gi\|45384078, gi\|... - gi\|996020\|emb\|CAA62832.1\| BRM protein [Gallus gallus], gi\|45384078\|ref\|NP_990470.1\| SWI/SNF related,...	604.0	[0..1]	[1249..104]
gi\|114620586 - gi\|114620586\|ref\|XP_519780.2\| PREDICTED: chromodomain helicase DNA binding protein 7 [Pan troglodyte...	599.0	[0..4]	[1212..412]
gi\|73986626 - gi\|73986626\|ref\|XP_867807.1\| PREDICTED: similar to SWI/SNF-related matrix-associated actin-dependent...	599.0	[0..1]	[1247..106]
CHD7_MOUSE - Chromodomain-helicase-DNA-binding protein 7 OS=Mus musculus GN=Chd7 PE=1 SV=1	599.0	[0..4]	[1212..362]
CHD7 - chromodomain helicase DNA binding protein 7 gi\|225000838 - gi\|225000838\|gb\|AAI72443.1\| Chromodomain helicase DNA binding protein 7 [synthetic construct]	597.0	[0..4]	[1212..368]

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Predicted Domain #1

Region A:
Residues: [1-276]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPYNSNYLS DNGKRKFSDE NPQSEVYGSS QTGLPSSYGN PQSYGTPPVQ QSSAMYGVNN  60
   61 SMGGGMYNTS ENTQFMNTDY SQTSSYASTP MSNAYSRDAP AAINNNFGYS YVGQSSQPVP 120
  121 SYNPLPSYNT ASLPNAGIPA AMPGMPSGYP GTVPIPQGGY NAHYSSPYNN GYPIGAVNPT 180
  181 SAIPAQPPAQ PVNNVLPSYV RSNSRSSARS TARSAPRSTQ RSRSSSANPV TTPPVNNTLL 240
  241 TPPAPPVELP PVTTTSPNAI IRSVQWIRSF VPQAPI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.221849
Match:	1m2vB
Description:	Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [277-349]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HQVINTLAQT KWDETAALSI LSQKYLSCDL GIPIQEHKRF KQSPVASNMP TYGSSNRTVQ  60
   61 SQKRSIRDKY IQM

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [350-508]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNDSTQASLM PSYTRKTSNA SKKLTTEEDE FYDSEEEPEA IVHRDTSALE RTVLNFINSS  60
   61 TAKELSDTAS CPLSHSKLLL EHRPFQTLAE ACIIKHPDDV PSKPGRRGRR REKNPMGQKI 120
  121 VNACMETMEG YYAIDNLIAK CEFLGNRISK GMASWGIKL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.41
Match:	1s5lU
Description:	Architecture of the photosynthetic oxygen evolving center
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [509-1105]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EMSNGELNIV DMESVPTEAA DNSDFPKFVT EQPKTLASDV QLKSYQLVGV NWLHLLYQQK  60
   61 LSGILADEMG LGKTCQVVAF FALLLEQGHH GPHLVVVPSS TLENWLRELA RFCPSLRVEP 120
  121 YYGSQQERAN IREAIEENEI KYDILVTTYQ LATNNKEDRS FLKHQNFDVC VYDEGHYLKN 180
  181 RMSERYKHLM NLNANFRLLL TGTPLQNNLK ELVSLLAFIL PNMFDSDMDD LDVIFKAKPT 240
  241 ADADIEQALL SKQRISRAKT MMTPFVLRRR KNQVLNDLPK KTQIIEHCKL SENQLEIYNR 300
  301 YAALQKNQQL RRDDKRNKRS KNDEESDGKS LSAGHVLMQL RKAANHALLF RKFYDDEKLK 360
  361 QMAKDIMQEE QYKNANEQYI YEDMEVMSDF ELHRLCRSFP TLQSYTLKDD PWMDSGKIRV 420
  421 LKELLPKMKE EGSRILLFSQ FTQMLDILEQ VLDTLKISYV RLDGSTQVEV RQDIIDQFHK 480
  481 EEDVTVFLLS TKAGGFGINL ACANVVILYD CSYNPFDDLQ AEDRAHRVGQ VREVTVIRLI 540
  541 TDNTIEEYIQ KLANTKLALD MSLSSDGKDR EEIGERLVQD MLDEENNGNN TKPEITG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	125.0
Match:	1z3iX
Description:	Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA-dependent ATPase activity	2.72462789867829	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.69246499202248	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.66107861968804	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
pyrophosphatase activity	2.61582393123755	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.59641929642359	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.59333672868803	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
DNA helicase activity	2.2817164193758	bayes_pls_golite062009
transporter activity	2.17383908004663	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
ATPase activity	2.11122403732968	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
transmembrane transporter activity	2.02444700826552	bayes_pls_golite062009
ATPase activity, coupled	1.8908019270286	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.88455339138556	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
microtubule motor activity	1.6537049553461	bayes_pls_golite062009
histone acetyltransferase activity	1.53262078944357	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.53262078944357	bayes_pls_golite062009
structural constituent of ribosome	1.47858140861683	bayes_pls_golite062009
hydrolase activity	1.35268825531078	bayes_pls_golite062009
motor activity	1.34881124154297	bayes_pls_golite062009
protein-DNA loading ATPase activity	1.29640539057136	bayes_pls_golite062009
structure-specific DNA binding	1.2539059700735	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
DNA clamp loader activity	1.12431517057397	bayes_pls_golite062009
double-stranded DNA binding	1.117585097627	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
substrate-specific transporter activity	0.97700154207756	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
structural molecule activity	0.86514677273731	bayes_pls_golite062009
transcription repressor activity	0.862685397469217	bayes_pls_golite062009
purine nucleotide binding	0.725611289205392	bayes_pls_golite062009
nucleotide binding	0.717697610309727	bayes_pls_golite062009
purine ribonucleotide binding	0.713814218071151	bayes_pls_golite062009
ribonucleotide binding	0.713752628021599	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.608058786636536	bayes_pls_golite062009
ATP binding	0.60527666756293	bayes_pls_golite062009
adenyl ribonucleotide binding	0.573214556107072	bayes_pls_golite062009
single-stranded DNA binding	0.568457189190858	bayes_pls_golite062009
adenyl nucleotide binding	0.554530910579109	bayes_pls_golite062009
transcription activator activity	0.537911793669378	bayes_pls_golite062009
cytoskeletal protein binding	0.500462538667228	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
N-acetyltransferase activity	0.324427816547256	bayes_pls_golite062009
mismatched DNA binding	0.31144582840038	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
four-way junction helicase activity	0.26252931460003	bayes_pls_golite062009
exodeoxyribonuclease V activity	0.185603938981231	bayes_pls_golite062009
RNA helicase activity	0.18426050934025	bayes_pls_golite062009
kinase activity	0.163756462988596	bayes_pls_golite062009
RNA-dependent ATPase activity	0.14606996093053	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.13050483816765	bayes_pls_golite062009
centromeric DNA binding	0.120185906020979	bayes_pls_golite062009
N-acyltransferase activity	0.117412028365885	bayes_pls_golite062009
active transmembrane transporter activity	0.114463153989353	bayes_pls_golite062009
microfilament motor activity	0.10236059675512	bayes_pls_golite062009
ion transmembrane transporter activity	0.081265446432119	bayes_pls_golite062009
3'-5' DNA helicase activity	0.0769112340058804	bayes_pls_golite062009
protein transporter activity	0.0397092337273124	bayes_pls_golite062009
actin binding	0.00482938540552702	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [1106-1163]

      1          11         21         31         41         51         
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    1 NESDGEFKVS SSNNSKQTDA EETNTGVPLE GSQPNSVEKT DLADGDEKAN IKTEMKSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.39794
Match:	2eyqA
Description:	Crystal structure of Escherichia coli transcription-repair coupling factor
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [1164-1284]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVEGDNKELR ETMKGENVQT DSNAAVPSSK SSTEEPNESV LSGHLDLDTE ASPVVSTIEK  60
   61 TTKGDVSVTE EQQSANIDGQ LEKPEIEESK KPDVLNQVSL SIEEEKPKNK ESEVDNNAAK 120
  121 D

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.0
Match:	1ofcX
Description:	nucleosome recognition module of ISWI ATPase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: