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View Structure Prediction Details

Protein: e-PA
Organism: Drosophila melanogaster
Length: 879 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for e-PA.

Description E-value Query
Range
Subject
Range
gi|75701558, gi|... - gi|75907833|ref|YP_322129.1| amino acid adenylation [Anabaena variabilis ATCC 29413], gi|75701558|gb...
725.0 [0..4] [879..527]

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Predicted Domain #1
Region A:
Residues: [1-565]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSLPQLSIV KGLQQDFVPR ALHRIFEEQQ LRHADKVALI YQPSTTGQGM APSQSSYRQM  60
   61 NERANRAARL LVAETHGRFL QPNSDGDFIV AVCMQPSEGL VTTLLAIWKA GGAYLPIDPS 120
  121 FPANRIHHIL LEAKPTLVIR DDDIDAGRFQ GTPTLSTTEL YAKSLQLAGS NLLSEEMLRG 180
  181 GNDHIAIVLY TSGSTGVPKG VRLPHESILN RLQWQWATFP YTANEAVSVF KTALTFVDSI 240
  241 AELWGPLMCG LAILVVPKAV TKDPQRLVAL LERYKIRRLV LVPTLLRSLL MYLKMEGGGA 300
  301 AQKLLYNLQI WVCSGEPLSV SLASSFFDYF DEGVHRLYNF YGSTEVLGDV TYFACESKKQ 360
  361 LSLYDNVPIG IPLSNTVVYL LDADYRPVKN GEIGEIFASG LNLAAGYVNG RDPERFLENP 420
  421 LAVEKKYARL YRTGDYGSLK NGSIMYEGRT DSQVKIRGHR VDLSEVEKNV AELPLVDKAI 480
  481 VLCYHAGQVD QAILAFVKLR DDAPMVTEMQ MEARLKDKLA DYMTPQVVIL EHVPLLVNGK 540
  541 VDRQALLKTY ETANNNEGDS SIVLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 115.0
Match: 1amuA
Description: Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity 5.90438437233818 bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds 4.4819902512335 bayes_pls_golite062009
acetate-CoA ligase activity 4.48129067128523 bayes_pls_golite062009
fatty acid ligase activity 3.10420612952117 bayes_pls_golite062009
acid-thiol ligase activity 2.89129353633634 bayes_pls_golite062009
long-chain fatty acid-CoA ligase activity 2.84227244567785 bayes_pls_golite062009
CoA-ligase activity 2.5960476232329 bayes_pls_golite062009
catalytic activity 1.83545185797733 bayes_pls_golite062009
binding 0.891362449667197 bayes_pls_golite062009
transcription regulator activity 0.742384980534643 bayes_pls_golite062009
transcription repressor activity 0.0862069150168795 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [566-659]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDYSQVPEDL KLTARDLFET VGGVIGRSTR ATLAPHSNFY ELGGNSLNSI FTVTLLREKG  60
   61 YNIGISEFIA AKNLGEIIEK MAANHDAVQL EEES

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.154902
Match: 2gdwA
Description: No description for 2gdwA was found.

Predicted functions:

Term Confidence Notes
acyl carrier activity 3.10595395492178 bayes_pls_golite062009
binding 1.13349407683239 bayes_pls_golite062009
catalytic activity 0.037428828577411 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [660-879]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNACPHLKME AVPLRLEHRQ EVIDIIVASF YNKADLEQWL KPGVLRTDYS DILNDIWNVL  60
   61 VERDLSFVVY DTNTDRIIGT ALNFDARNEP EVDIKSKLLI VFEFLEFCEG PIRDNYLPKG 120
  121 LNQILHSFMM GTAEKLNPRE NIACMHFMEH EVLRVAREKQ FAGIFTTNTS PLTQQLADVY 180
  181 HYKTLLNFQV NEYVHSDGSR PFGDAPDEQR AIVHWKEVGK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 1l5aA
Description: VibH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
dihydrolipoamide S-acyltransferase activity 4.95288540231937 bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity 4.825154128623 bayes_pls_golite062009
S-acetyltransferase activity 4.79325739487657 bayes_pls_golite062009
S-acyltransferase activity 4.44987112475286 bayes_pls_golite062009
acyltransferase activity 3.08588280042054 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.027770031317 bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity 3.02354522717247 bayes_pls_golite062009
S-succinyltransferase activity 3.02354522717247 bayes_pls_golite062009
transferase activity, transferring acyl groups 2.50610942105142 bayes_pls_golite062009
pyruvate dehydrogenase activity 2.43159394927614 bayes_pls_golite062009
ligase activity 2.34510379638968 bayes_pls_golite062009
carnitine O-acyltransferase activity 2.07401053954424 bayes_pls_golite062009
acetyltransferase activity 2.00891466032088 bayes_pls_golite062009
transferase activity 1.78692523095641 bayes_pls_golite062009
catalytic activity 1.51562638409295 bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity 0.797801402758281 bayes_pls_golite062009
binding 0.788999584656706 bayes_pls_golite062009
O-acyltransferase activity 0.731328511162172 bayes_pls_golite062009
O-palmitoyltransferase activity 0.69903206436468 bayes_pls_golite062009
carnitine O-palmitoyltransferase activity 0.69903206436468 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 0.651721897180987 bayes_pls_golite062009
succinyltransferase activity 0.271602729407812 bayes_pls_golite062009
carnitine O-acetyltransferase activity 0.203430690130141 bayes_pls_golite062009
palmitoyltransferase activity 0.200750596708501 bayes_pls_golite062009
protein binding 0.104367069798378 bayes_pls_golite062009
O-acetyltransferase activity 0.0500725150648709 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle