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View Structure Prediction Details

Protein: hppy-PA
Organism: Drosophila melanogaster
Length: 1218 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hppy-PA.

Description E-value Query
Range
Subject
Range
gi|118780006, gi... - gi|118780006|ref|XP_309868.3| ENSANGP00000018210 [Anopheles gambiae str. PEST], gi|116131441|gb|EAA0...
812.0 [0..3] [1218..2]

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Predicted Domain #1
Region A:
Residues: [1-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAHSHHNA NMLSSDISRR NPQDEYELIQ KIGSGTYGDV YKAKRIQSNE LAAIKVIKLE  60
   61 PSDDIQIIQQ EIIMMRDCRH PNIIAYYGSY LRRDKLWICM EFCGGGSLQD IYQVTGPLTE 120
  121 VQIAYMCRET LKGLEYLHSM GKMHRDIKGA NILLTEYGDV KLADFGVSAQ ITATINKRKS 180
  181 FIGTPYWMAP EVAAVERKGG YNQLCDIWAC GITAIELAEL QPPMFDLHPM RALFLMSKSG 240
  241 FKPPTLNNKD KWSPTFHNFI KTALTKNPKK RPTAERLLQH PFVQCEMSLR VAKELLQKYQ 300
  301 SP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.522879
Match: 2j51A
Description: No description for 2j51A was found.

Predicted functions:

Term Confidence Notes
acetylcholine receptor activator activity 5.9159846946654 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.94085498993561 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
small conjugating protein ligase activity 1.74206248731815 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
ErbB-3 class receptor binding 1.34841233233438 bayes_pls_golite062009
ErbB-2 class receptor binding 1.33825339298024 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.25285260301349 bayes_pls_golite062009
acid-amino acid ligase activity 1.2266791546014 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity 1.11664317075762 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.10045286406485 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.10045286406485 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
insulin receptor substrate binding 0.98689034826741 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
nucleic acid binding 0.794058505655489 bayes_pls_golite062009
transcription regulator activity 0.775404673285876 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
DNA binding 0.714163549867672 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transcription repressor activity 0.568332175782799 bayes_pls_golite062009
transcription factor activity 0.563262875317016 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.51726292539973 bayes_pls_golite062009
activin binding 0.510364757301021 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
structural constituent of muscle 0.399773397398032 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
tubulin binding 0.385009627613955 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.188254408239569 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009
brain-derived neurotrophic factor binding 0.00315481858218991 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [303-403]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPQFYYYLDG DEESVAGVPQ RIASKMTSRT NGVPAQNHTL KTGMTTNSTW NERSSSPETL  60
   61 PSDMSLLQYI DEELKLRATL PLNNDTKDPL GAECSCSSHN G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [404-607]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAAGGGGGGG VGVGAGGAAA NGSSSSSGGA TVGTTHHQHQ QHHQHHHHPN HLHQHQSHQL  60
   61 PQQQQQQSHQ AAQQEHHHHH PMTSSISSGL VTANANNISS SASLASMPGL SAYLGMRSHV 120
  121 VGHMGMGFGM GLGMSNLRTT SIDADDDELV AADVAMNNAA AAVPGNGSGA GNGSGSGCSA 180
  181 SAAHYLRYSS NYRSAAAAQA SQAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [608-730]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPHVNSNSNS NNGHGHAPIT SSISSSASSA SFYNRLLLLD NSSGDAVVGG NGGGSSNISS  60
   61 SGGASSGTNG LLDKHELDAL PQAATKSAGD GFSHSNSPTA NSGAGATGSR DNDGPSSSNS 120
  121 SHL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [731-857]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQNLLRSSSG ETPAGSSSAG NNCDYRHENN QNGLEDSPRR HSSMDQLIGL LENMGKSPRT  60
   61 RSLSDGGTQD DDEAEKEAQP DLLNNTPPVP PKRSHKRRHT PPRPISNGLP PTPKVHMGAC 120
  121 FSKIFNG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [858-1084]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPLRVHCTAS WIHPETRDQH LLIGAEEGIY NLNMNELHDA AIDQLFPRRT TWLYVIKDVL  60
   61 MSLSGKSCQL YRHDLVALHS KQTVRFSLHM NKIPERLVPR KFALTTKVPD TKCCTQCCVT 120
  121 RNPYNGYKYL CGATPSGIFL MQWYDPLNKF MLLKQCEWPA ISIQGGGHGC VQNGHTPVFE 180
  181 MIITPELEYP IVCTGVRKAM NGCLKLELIN MNSASWFHSE DLEYDAM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1085-1218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATMVPRRDLL KVVRVHQVEK DAILVCYGNL IQVVTLQGNP KQHKKMVSQL NFDFNVDSIV  60
   61 CLPDSVLAFH KHGMQGKSLR NGEVTQEIKD MSRTYRLLGS DKVVALESQL LRTGSLGSEE 120
  121 GHDLYILAGH EASY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle