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View Structure Prediction Details

Protein: Su(var)2-10-PC
Organism: Drosophila melanogaster
Length: 565 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Su(var)2-10-PC.

Description E-value Query
Range		 Subject
Range
gi|220950582 - gi|220950582|gb|ACL87834.1| Su(var)2-10-PA [synthetic construct]
Su(var)2-10-PD - The gene Suppressor of variegation 2-10 is referred to in FlyBase by the symbol Dmel\Su(var)2-10 (CG...
 538.0 [0..2] [565..36]

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Predicted Domain #1
Region A:
Residues: [1-66] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFPSLQECE QMVQMLRVVE LQKILSFLNI SFAGRKTDLQ SRILSFLRTN LELLAPKVQE  60
   61 VYAQSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.39794
Match: 1v66A
Description: Solution structure of human p53 binding domain of PIAS-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SUMO ligase activity 7.09211721404578 bayes_pls_golite062009
small conjugating protein ligase activity 5.19208367271658 bayes_pls_golite062009
acid-amino acid ligase activity 4.23914967265256 bayes_pls_golite062009
transcription regulator activity 3.41663142583782 bayes_pls_golite062009
DNA binding 3.10342439340038 bayes_pls_golite062009
nucleic acid binding 3.06883460395012 bayes_pls_golite062009
binding 2.85946414867169 bayes_pls_golite062009
transcription repressor activity 2.74753557795928 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.29668422758615 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.24838171947021 bayes_pls_golite062009
transcription corepressor activity 2.19580341360526 bayes_pls_golite062009
transcription coactivator activity 2.00568376574074 bayes_pls_golite062009
transcription factor binding 1.87393007510949 bayes_pls_golite062009
transcription cofactor activity 1.74991817705903 bayes_pls_golite062009
steroid hormone receptor binding 1.6614513749396 bayes_pls_golite062009
hormone receptor binding 1.54663504907102 bayes_pls_golite062009
protein binding 1.4634286530239 bayes_pls_golite062009
androgen receptor binding 1.42204964058772 bayes_pls_golite062009
transcription activator activity 1.33699031660219 bayes_pls_golite062009
nuclear hormone receptor binding 1.31532203831033 bayes_pls_golite062009
chromatin binding 0.65047159761755 bayes_pls_golite062009
receptor binding 0.52768617849698 bayes_pls_golite062009
catalytic activity 0.454272578060498 bayes_pls_golite062009
ligase activity 0.36302660895622 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [67-146] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEQNATLQYI DPTRMYSHIQ LPPTVQPNPV GLVGSGQGVQ VPGGQMNVVG GAPFLHTHSI  60
   61 NSQLPIHPDV RLKKLAFYDV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [147-317] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGTLIKPSTL VPRNTQRVQE VPFYFTLTPQ QATEIASNRD IRNSSKVEHA IQVQLRFCLV  60
   61 ETSCDQEDCF PPNVNVKVNN KLCQLPNVIP TNRPNVEPKR PPRPVNVTSN VKLSPTVTNT 120
  121 ITVQWCPDYT RSYCLAVYLV KKLTSTQLLQ RMKTKGVKPA DYTRGLIKEK L

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [318-412] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEDADCEIAT TMLKVSLNCP LGKMKMLLPC RASTCSHLQC FDASLYLQMN ERKPTWNCPV  60
   61 CDKPAIYDNL VIDGYFQEVL GSSLLKSDDT EIQLH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.154902
Match: 2yu4A
Description: No description for 2yu4A was found.

Predicted Domain #5
Region A:
Residues: [413-565] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDGSWSTPGL RSETQILDTP SKPAQKVEVI SDDIELISDD AKPVKRDLSP AQDEQPTSTS  60
   61 NSETVDLTLS DSDDDMPLAK RRPPAKQAVA SSTSNGSGGG QRAYTPAQQP QQSGGNVFKK 120
  121 PQKAEELYKR VHLGVWLRPR KPKPESSRRP NVG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle