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View Structure Prediction Details

Protein: NTH1_MOUSE, NTHL...
Organism: Mus musculus
Length: 300 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTH1_MOUSE, NTHL....

Description E-value Query
Range
Subject
Range
gi|149052032, gi... - gi|34870522|ref|XP_213228.2| PREDICTED: similar to Endonuclease III-like protein 1 [Rattus norvegicu...
254.0 [0..1] [300..1]
gi|116129783, gi... - gi|118782892|ref|XP_312566.3| ENSANGP00000014971 [Anopheles gambiae str. PEST], gi|116129783|gb|EAA0...
239.0 [0..1] [297..1]
NTHL1 - nth endonuclease III-like 1 (E. coli)
237.0 [0..6] [300..15]
gi|109127234 - gi|109127234|ref|XP_001082772.1| PREDICTED: nth endonuclease III-like 1 [Macaca mulatta]
232.0 [0..6] [300..15]
gi|28202547, gi|... - gi|28210111|ref|NP_781055.1| endonuclease III [Clostridium tetani E88], gi|28202547|gb|AAO34992.1| e...
228.0 [0..91] [297..3]
gi|20808188 - gi|20808188|ref|NP_623359.1| predicted EndoIII-related endonuclease [Thermoanaerobacter tengcongensi...
gi|20808188, gi|... - gi|20808188|ref|NP_623359.1| EndoIII-related endonuclease [Thermoanaerobacter tengcongensis MB4], gi...
226.0 [0..87] [298..1]

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Predicted Domain #1
Region A:
Residues: [1-74]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSGVRMVTR SRSRATRIAS EGCREELAPR EAAAEGRKSH RPVRHPRRTQ KTHVAYEAAN  60
   61 GEEGEDAEPL KVPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [75-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WEPQNWQQQL ANIRIMRSKK DAPVDQLGAE HCYDASAPPK VRRYQVLLSL MLSSQTKDQV  60
   61 TAGAMQRLRA RGLTVESILQ TDDDTLGRLI YPVGFWRNKV KYIKQTTAIL QQRYEGDIPA 120
  121 SVAELVALPG VGPKMAHLAM AVAWGTISGI AVDTHVHRIA NRLRWTKKMT KTPEETRKNL 180
  181 EEWLPRVLWS EVNGLLVGFG QQICLPVHPR CQACLNKALC PAAQDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.09691
Match: 2abkA
Description: REFINEMENT OF THE NATIVE STRUCTURE OF ENDONUCLEASE III TO A RESOLUTION OF 1.85 ANGSTROM
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA N-glycosylase activity 4.8124964619976 bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds 4.26870112679392 bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity 3.71152530486175 bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity 2.49872706126491 bayes_pls_golite062009
hydrolase activity 2.39042189031819 bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity 2.21048599823382 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 2.18053745735048 bayes_pls_golite062009
catalytic activity 2.13345932727422 bayes_pls_golite062009
damaged DNA binding 2.00388798014411 bayes_pls_golite062009
alkylbase DNA N-glycosylase activity 1.5832578018127 bayes_pls_golite062009
DNA binding 1.44394874535958 bayes_pls_golite062009
nucleic acid binding 1.36800347239439 bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity 1.32985950765371 bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity 1.2016453685638 bayes_pls_golite062009
binding 1.15752946565805 bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity 1.06383943982125 bayes_pls_golite062009
uracil DNA N-glycosylase activity 0.879508131574476 bayes_pls_golite062009
structure-specific DNA binding 0.85419760398899 bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity 0.68578837518217 bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity 0.661651574677137 bayes_pls_golite062009
double-stranded DNA binding 0.57099109384393 bayes_pls_golite062009
transcription regulator activity 0.493252955870142 bayes_pls_golite062009
protein binding 0.0921713980805489 bayes_pls_golite062009
carbon-oxygen lyase activity 0.0676784802238829 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle