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View Structure Prediction Details

Protein: RFA1_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 609 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RFA1_SCHPO.

Description E-value Query
Range		 Subject
Range
gi|114665746 - gi|114665746|ref|XP_511254.2| PREDICTED: replication protein A1, 70kDa [Pan troglodytes]
 611.0 [0..1] [608..55]
gi|62089044 - gi|62089044|dbj|BAD92969.1| replication protein A1, 70kDa variant [Homo sapiens]
 609.0 [0..1] [608..15]
gi|115496244, gi... - gi|115496244|ref|NP_001068644.1| replication protein A1, 70kDa [Bos taurus], gi|111308484|gb|AAI1998...
 608.0 [0..1] [608..1]
gi|28922877, gi|... - gi|32404590|ref|XP_322908.1| hypothetical protein [Neurospora crassa], gi|28922877|gb|EAA32097.1| re...
gi|85102469 - gi|85102469|ref|XP_961333.1| replication factor-A protein 1 [Neurospora crassa OR74A]
 604.0 [0..1] [607..1]
RFA1_PONPY - Replication protein A 70 kDa DNA-binding subunit - Pongo pygmaeus (Orangutan)
RFA1_PONAB - Replication protein A 70 kDa DNA-binding subunit OS=Pongo abelii GN=RPA1 PE=2 SV=1
 596.0 [0..1] [608..1]
gi|73967220 - gi|73967220|ref|XP_868491.1| PREDICTED: similar to Replication protein A 70 kDa DNA-binding subunit ...
 595.0 [0..1] [608..1]
gi|74195701, gi|... - gi|74195701|dbj|BAE39655.1| unnamed protein product [Mus musculus], gi|74143871|dbj|BAE41250.1| unna...
 594.0 [0..1] [608..1]

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Predicted Domain #1
Region A:
Residues: [1-174] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAERLSVGAL RIINTSDASS FPPNPILQVL TVKELNSNPT SGAPKRYRVV LSDSINYAQS  60
   61 MLSTQLNHLV AENKLQKGAF VQLTQFTVNV MKERKILIVL GLNVLTELGV MDKIGNPAGL 120
  121 ETVDALRQQQ NEQNNASAPR TGISTSTNSF YGNNAAATAP APPPMMKKPA APNS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.522879
Match: 2b29A
Description: N-terminal domain of the RPA70 subunit of human replication protein A.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telomeric DNA binding 7.07761964836826 bayes_pls_golite062009
single-stranded telomeric DNA binding 6.04637014849887 bayes_pls_golite062009
telomerase inhibitor activity 5.40477712257453 bayes_pls_golite062009
nucleic acid binding 4.02967008021862 bayes_pls_golite062009
DNA binding 3.62735703519187 bayes_pls_golite062009
single-stranded DNA binding 3.59212997362902 bayes_pls_golite062009
structure-specific DNA binding 3.53214384646348 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
structural constituent of ribosome 2.25006883439646 bayes_pls_golite062009
transcription regulator activity 2.20239961025491 bayes_pls_golite062009
structural molecule activity 2.07809455998137 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
DNA helicase activity 1.12203697857261 bayes_pls_golite062009
transcription factor activity 1.05816813143865 bayes_pls_golite062009
sequence-specific DNA binding 0.86170694706755 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
hydrolase activity 0.724860465280978 bayes_pls_golite062009
DNA-dependent ATPase activity 0.638831894247026 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
DEAD/H-box RNA helicase binding 0.440977654731901 bayes_pls_golite062009
translation regulator activity 0.41164963411369 bayes_pls_golite062009
double-stranded DNA binding 0.378383789953688 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.360862776629591 bayes_pls_golite062009
nucleotidyltransferase activity 0.325774164899685 bayes_pls_golite062009
four-way junction helicase activity 0.31769813397725 bayes_pls_golite062009
RNA binding 0.31028563542112 bayes_pls_golite062009
translation initiation factor activity 0.30211828233765 bayes_pls_golite062009
exonuclease activity 0.28313884527829 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.226916777208049 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.223941674251642 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.125256208482441 bayes_pls_golite062009
exoribonuclease activity 0.109774918833391 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.0954216620147701 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.0179535526984695 bayes_pls_golite062009
helicase activity 0.0121541775159524 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [175-432] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSTIIYPIEG LSPYQNKWTI RARVTNKSEV KHWHNQRGEG KLFSVNLLDE SGEIRATGFN  60
   61 DQVDAFYDIL QEGSVYYISR CRVNIAKKQY TNVQNEYELM FERDTEIRKA EDQTAVPVAK 120
  121 FSFVSLQEVG DVAKDAVIDV IGVLQNVGPV QQITSRATSR GFDKRDITIV DQTGYEMRVT 180
  181 LWGKTAIEFS VSEESILAFK GVKVNDFQGR SLSMLTSSTM SVDPDIQESH LLKGWYDGQG 240
  241 RGQEFAKHSV ISSTLSTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.30103
Match: 1jmcA
Description: Replication protein A 70 KDa subunit (RPA70)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telomeric DNA binding 7.07761964836826 bayes_pls_golite062009
single-stranded telomeric DNA binding 6.04637014849887 bayes_pls_golite062009
telomerase inhibitor activity 5.40477712257453 bayes_pls_golite062009
nucleic acid binding 4.02967008021862 bayes_pls_golite062009
DNA binding 3.62735703519187 bayes_pls_golite062009
single-stranded DNA binding 3.59212997362902 bayes_pls_golite062009
structure-specific DNA binding 3.53214384646348 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
structural constituent of ribosome 2.25006883439646 bayes_pls_golite062009
transcription regulator activity 2.20239961025491 bayes_pls_golite062009
structural molecule activity 2.07809455998137 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
DNA helicase activity 1.12203697857261 bayes_pls_golite062009
transcription factor activity 1.05816813143865 bayes_pls_golite062009
sequence-specific DNA binding 0.86170694706755 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
hydrolase activity 0.724860465280978 bayes_pls_golite062009
DNA-dependent ATPase activity 0.638831894247026 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
DEAD/H-box RNA helicase binding 0.440977654731901 bayes_pls_golite062009
translation regulator activity 0.41164963411369 bayes_pls_golite062009
double-stranded DNA binding 0.378383789953688 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.360862776629591 bayes_pls_golite062009
nucleotidyltransferase activity 0.325774164899685 bayes_pls_golite062009
four-way junction helicase activity 0.31769813397725 bayes_pls_golite062009
RNA binding 0.31028563542112 bayes_pls_golite062009
translation initiation factor activity 0.30211828233765 bayes_pls_golite062009
exonuclease activity 0.28313884527829 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.226916777208049 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.223941674251642 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.125256208482441 bayes_pls_golite062009
exoribonuclease activity 0.109774918833391 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.0954216620147701 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.0179535526984695 bayes_pls_golite062009
helicase activity 0.0121541775159524 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [433-609] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRSAERKNIA EVQAEHLGMS ETPDYFSLKG TIVYIRKKNV SYPACPAADC NKKVFDQGGS  60
   61 WRCEKCNKEY DAPQYRYIIT IAVGDHTGQL WLNVFDDVGK LIMHKTADEL NDLQENDENA 120
  121 FMNCMAEACY MPYIFQCRAK QDNFKGEMRV RYTVMSINQM DWKEESKRLI NFIESAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1l1oC
Description: Replication protein A 70 KDa subunit (RPA70)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telomeric DNA binding 7.07761964836826 bayes_pls_golite062009
single-stranded telomeric DNA binding 6.04637014849887 bayes_pls_golite062009
telomerase inhibitor activity 5.40477712257453 bayes_pls_golite062009
nucleic acid binding 4.02967008021862 bayes_pls_golite062009
DNA binding 3.62735703519187 bayes_pls_golite062009
single-stranded DNA binding 3.59212997362902 bayes_pls_golite062009
structure-specific DNA binding 3.53214384646348 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
structural constituent of ribosome 2.25006883439646 bayes_pls_golite062009
transcription regulator activity 2.20239961025491 bayes_pls_golite062009
structural molecule activity 2.07809455998137 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
DNA helicase activity 1.12203697857261 bayes_pls_golite062009
transcription factor activity 1.05816813143865 bayes_pls_golite062009
sequence-specific DNA binding 0.86170694706755 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
hydrolase activity 0.724860465280978 bayes_pls_golite062009
DNA-dependent ATPase activity 0.638831894247026 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
DEAD/H-box RNA helicase binding 0.440977654731901 bayes_pls_golite062009
translation regulator activity 0.41164963411369 bayes_pls_golite062009
double-stranded DNA binding 0.378383789953688 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.360862776629591 bayes_pls_golite062009
nucleotidyltransferase activity 0.325774164899685 bayes_pls_golite062009
four-way junction helicase activity 0.31769813397725 bayes_pls_golite062009
RNA binding 0.31028563542112 bayes_pls_golite062009
translation initiation factor activity 0.30211828233765 bayes_pls_golite062009
exonuclease activity 0.28313884527829 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.226916777208049 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.223941674251642 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.125256208482441 bayes_pls_golite062009
exoribonuclease activity 0.109774918833391 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.0954216620147701 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.0179535526984695 bayes_pls_golite062009
helicase activity 0.0121541775159524 bayes_pls_golite062009
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