YRC Public Data Repository - Protein Structure Prediction

Protein:	CUL1
Organism:	Homo sapiens
Length:	776 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUL1.

Description	E-value	Query Range	Subject Range
gi\|74150930 - gi\|74150930\|dbj\|BAE27601.1\| unnamed protein product [Mus musculus]	0.0	[1..776]	[1..776]
gi\|117645952 - gi\|117645952\|emb\|CAL38443.1\| hypothetical protein [synthetic construct] gi\|31873320 - gi\|31873320\|emb\|CAD97651.1\| hypothetical protein [Homo sapiens] HGNC:2551\|MIM:60... - 1	0.0	[1..776]	[1..776]
gi\|73978425 - gi\|73978425\|ref\|XP_848402.1\| PREDICTED: similar to Cullin-1 (CUL-1) isoform 3 [Canis familiaris] tr\|F1MYD0\|F1MYD0... - Uncharacterized protein OS=Bos taurus GN=CUL1 PE=3 SV=2 gi\|194210081 - gi\|194210081\|ref\|XP_001504677.2\| PREDICTED: similar to SCF complex protein cul-1 isoform 1 [Equus ca...	0.0	[1..776]	[1..776]
gi\|148233772, gi... - gi\|66911536\|gb\|AAH97675.1\| MGC114992 protein [Xenopus laevis], gi\|148233772\|ref\|NP_001089475.1\| hypo...	0.0	[1..776]	[1..776]
gi\|92919088, gi\|... - gi\|92919088\|gb\|ABE96895.1\| cullin-1 [Xenopus tropicalis], gi\|113931606\|ref\|NP_001039255.1\| cullin 1 ...	0.0	[1..776]	[1..776]
gi\|169158288, gi... - gi\|45433528\|ref\|NP_955953.2\| cullin 1 [Danio rerio], gi\|42542528\|gb\|AAH66480.1\| Cullin 1a [Danio rer...	0.0	[1..776]	[1..777]
gi\|76616217 - gi\|76616217\|ref\|XP_881792.1\| PREDICTED: similar to Cullin-1 (CUL-1) isoform 3 [Bos taurus]	0.0	[1..776]	[1..776]

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Predicted Domain #1

Region A:
Residues: [1-776]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY NYCTSVHQSN  60
   61 QARGAGVPPS KSKKGQTPGG AQFVGLELYK RLKEFLKNYL TNLLKDGEDL MDESVLKFYT 120
  121 QQWEDYRFSS KVLNGICAYL NRHWVRRECD EGRKGIYEIY SLALVTWRDC LFRPLNKQVT 180
  181 NAVLKLIEKE RNGETINTRL ISGVVQSYVE LGLNEDDAFA KGPTLTVYKE SFESQFLADT 240
  241 ERFYTRESTE FLQQNPVTEY MKKAEARLLE EQRRVQVYLH ESTQDELARK CEQVLIEKHL 300
  301 EIFHTEFQNL LDADKNEDLG RMYNLVSRIQ DGLGELKKLL ETHIHNQGLA AIEKCGEAAL 360
  361 NDPKMYVQTV LDVHKKYNAL VMSAFNNDAG FVAALDKACG RFINNNAVTK MAQSSSKSPE 420
  421 LLARYCDSLL KKSSKNPEEA ELEDTLNQVM VVFKYIEDKD VFQKFYAKML AKRLVHQNSA 480
  481 SDDAEASMIS KLKQACGFEY TSKLQRMFQD IGVSKDLNEQ FKKHLTNSEP LDLDFSIQVL 540
  541 SSGSWPFQQS CTFALPSELE RSYQRFTAFY ASRHSGRKLT WLYQLSKGEL VTNCFKNRYT 600
  601 LQASTFQMAI LLQYNTEDAY TVQQLTDSTQ IKMDILAQVL QILLKSKLLV LEDENANVDE 660
  661 VELKPDTLIK LYLGYKNKKL RVNINVPMKT EQKQEQETTH KNIEEDRKLL IQAAIVRIMK 720
  721 MRKVLKHQQL LGEVLTQLSS RFKPRVPVIK KCIDILIEKE YLERVDGEKD TYSYLA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1u6gA
Description:	Crystal Structure of The Cand1-Cul1-Roc1 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	9.95820721075934	bayes_pls_golite062009
small conjugating protein ligase activity	9.63704265478699	bayes_pls_golite062009
acid-amino acid ligase activity	8.59660059921406	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	7.32718329074249	bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity	6.69190468636718	bayes_pls_golite062009
transcription regulator activity	4.76121492612224	bayes_pls_golite062009
ligase activity	4.08678005991666	bayes_pls_golite062009
transcription factor activity	3.7855017556511	bayes_pls_golite062009
binding	2.45185337633142	bayes_pls_golite062009
transcription repressor activity	2.39237599101586	bayes_pls_golite062009
protein binding	2.34145982999922	bayes_pls_golite062009
transcription activator activity	2.05043065144612	bayes_pls_golite062009
nucleic acid binding	1.54797684894025	bayes_pls_golite062009
DNA binding	1.42215436462553	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.23862224095769	bayes_pls_golite062009
transporter activity	0.891050405674973	bayes_pls_golite062009
transmembrane transporter activity	0.648150681919233	bayes_pls_golite062009
transcription factor binding	0.612315945412079	bayes_pls_golite062009
substrate-specific transporter activity	0.368917395770011	bayes_pls_golite062009
catalytic activity	0.351553138703956	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.249771970501337	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.146182977030285	bayes_pls_golite062009
hydrolase activity	0.140191206949582	bayes_pls_golite062009
structure-specific DNA binding	0.117670813298683	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.107671044044222	bayes_pls_golite062009
transferase activity	0.064832527337659	bayes_pls_golite062009
specific transcriptional repressor activity	0.0565989703351002	bayes_pls_golite062009
sequence-specific DNA binding	0.0102780098866235	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: