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View Structure Prediction Details

Protein: C10orf2
Organism: Homo sapiens
Length: 684 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for C10orf2.

Description E-value Query
Range
Subject
Range
gi|109090289 - gi|109090289|ref|XP_001109287.1| PREDICTED: similar to twinkle [Macaca mulatta]
0.0 [1..684] [1..684]
PEO1_MOUSE - Twinkle protein, mitochondrial OS=Mus musculus GN=Peo1 PE=2 SV=1
0.0 [1..683] [1..684]
gi|27684485, gi|... - gi|27684485|ref|XP_219939.1| PREDICTED: similar to twinkle [Rattus norvegicus], gi|157821325|ref|NP_...
0.0 [1..684] [1..683]
gi|57107533 - gi|57107533|ref|XP_543974.1| PREDICTED: similar to twinkle [Canis familiaris]
0.0 [1..684] [1..684]
gi|76654802 - gi|76654802|ref|XP_580526.2| PREDICTED: similar to twinkle [Bos taurus]
0.0 [1..640] [1..639]
gi|56462549, gi|... - gi|56462549|emb|CAI10924.1| progressive external ophthalmoplegia 1 [Homo sapiens], gi|255304946|ref|...
0.0 [1..576] [1..576]
gi|46250208, gi|... - gi|46250208|gb|AAH68751.1| MGC81247 protein [Xenopus laevis], gi|147907413|ref|NP_001084540.1| hypot...
4.0E-85 [1..654] [4..672]
gi|48728623, gi|... - gi|77461369|ref|YP_350876.1| DNA primase [Pseudomonas fluorescens Pf0-1], gi|77385372|gb|ABA76885.1|...
5.0E-72 [40..426] [5..434]

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Predicted Domain #1
Region A:
Residues: [1-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWVLLRSGYP LRILLPLRGE WMGRRGLPRN LAPGPPRRRY RKETLQALDM PVLPVTATEI  60
   61 RQYLRGHGIP FQDGHSCLRA LSPFAESSQL KGQTGVTTSF SLFIDKTTGH FLCMTSLAEG 120
  121 SWEDFQASVE GRGDGAREGF LLSKAPEFED SEEVRRIWNR AIPLWELPDQ E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.69897
Match: 2au3A
Description: Crystal Structure of the Aquifex aeolicus primase (Zinc Binding and RNA Polymerase Domains)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [172-684]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVQLADTMFG LTKVTDDTLK RFSVRYLRPA RSLVFPWFSP GGSGLRGLKL LEAKCQGDGV  60
   61 SYEETTIPRP SAYHNLFGLP LISRRDAEVV LTSRELDSLA LNQSTGLPTL TLPRGTTCLP 120
  121 PALLPYLEQF RRIVFWLGDD LRSWEAAKLF ARKLNPKRCF LVRPGDQQPR PLEALNGGFN 180
  181 LSRILRTALP AWHKSIVSFR QLREEVLGEL SNVEQAAGLR WSRFPDLNRI LKGHRKGELT 240
  241 VFTGPTGSGK TTFISEYALD LCSQGVNTLW GSFEISNVRL ARVMLTQFAE GRLEDQLDKY 300
  301 DHWADRFEDL PLYFMTFHGQ QSIRTVIDTM QHAVYVYDIC HVIIDNLQFM MGHEQLSTDR 360
  361 IAAQDYIIGV FRKFATDNNC HVTLVIHPRK EDDDKELQTA SIFGSAKASQ EADNVLILQD 420
  421 RKLVTGPGKR YLQVSKNRFD GDVGVFPLEF NKNSLTFSIP PKNKARLKKI KDDTGPVAKK 480
  481 PSSGKKGATT QNSEICSGQA PTPDQPDTSK RSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.522879
Match: 1q57A
Description: The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA primase activity 5.58425508363583 bayes_pls_golite062009
DNA-directed RNA polymerase activity 3.06119235645036 bayes_pls_golite062009
RNA polymerase activity 3.06119235645036 bayes_pls_golite062009
binding 2.0681607836408 bayes_pls_golite062009
pyrophosphatase activity 1.49611313354225 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
nucleic acid binding 0.913322399315129 bayes_pls_golite062009
DNA-dependent ATPase activity 0.742401164348338 bayes_pls_golite062009
helicase activity 0.701689608967233 bayes_pls_golite062009
protein binding 0.378225828131122 bayes_pls_golite062009
DNA binding 0.376487324624615 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.3625050107782 bayes_pls_golite062009
DNA helicase activity 0.286798609263816 bayes_pls_golite062009
DNA clamp loader activity 0.27925703205288 bayes_pls_golite062009
transcription regulator activity 0.150159515184919 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.146865639513637 bayes_pls_golite062009
ATP-dependent helicase activity 0.146865639513637 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
DNA polymerase activity 4.95561462330096E-4 bayes_pls_golite062009

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