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View Structure Prediction Details

Protein: RDH54
Organism: Saccharomyces cerevisiae
Length: 924 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RDH54.

Description E-value Query
Range
Subject
Range
RDH54 - DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; i...
0.0 [1..924] [1..924]
gi|44985583 - gi|44985583|gb|AAS54279.1| AGL212Wp [Ashbya gossypii ATCC 10895]
gi|45200885, gi|... - gi|45200885|ref|NP_986455.1| AGL212Wp [Ashbya gossypii ATCC 10895], gi|44985583|gb|AAS54279.1| AGL21...
7.0E-97 [1..915] [5..900]
CHD5 - chromodomain helicase DNA binding protein 5
gi|151555557, gi... - gi|151555557|gb|AAI48804.1| Chromodomain helicase DNA binding protein 5 [synthetic construct], gi|14...
8.0E-88 [3..909] [447..1315]
kis-PA - The gene kismet is referred to in FlyBase by the symbol Dmel\kis (CG3696, FBgn0086902). It is a prot...
3.0E-84 [2..885] [1755..2626]
gi|38173711, gi|... - gi|47086607|ref|NP_997881.1| SWI/SNF related, matrix associated, actin dependent regulator of chroma...
7.0E-83 [4..900] [419..1333]
SNF22_SCHPO - SWI/SNF chromatin-remodeling complex subunit snf22 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2...
snf22 - ATP-dependent DNA helicase Snf22
2.0E-80 [24..908] [624..1449]
gi|49069018, gi|... - gi|71005328|ref|XP_757330.1| hypothetical protein UM01183.1 [Ustilago maydis 521], ref|XP_398798.1| ...
2.0E-80 [68..909] [598..1407]

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Predicted Domain #1
Region A:
Residues: [1-185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQIPKYENKP FKPPRRVGSN KYTQLKPTAT AVTTAPISKA KVTVNLKRSI SAGPTLNLAK  60
   61 KPNNLSSNEN TRYFTIMYRK PTTKKHKTWS GDGYATLKAS SDKLCFYNEA GKFLGSSMLP 120
  121 SDSDSLFETL FKAGSNEVQL DYELKENAEI RSAKEALSQN MGNPSPPTTS TTETVPSTKN 180
  181 DGGKY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [186-254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMPLSQLFSL NTVKRFKSVT KQTNEHMTTV PKTSQNSKAK KYYPVFDVNK IDNPIVMNKN  60
   61 AAAEVDVIV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.11222585187695 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.02893949194171 bayes_pls_golite062009
pyrophosphatase activity 1.97909493766908 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.95844964816653 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.95658009428828 bayes_pls_golite062009
DNA binding 1.7904783386531 bayes_pls_golite062009
transcription regulator activity 1.68903321260301 bayes_pls_golite062009
ATPase activity 1.42257610975945 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
helicase activity 1.16085745407703 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
hydrolase activity 0.98565595572967 bayes_pls_golite062009
ATPase activity, coupled 0.732723553251109 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
purine nucleotide binding 0.725611289205392 bayes_pls_golite062009
structure-specific DNA binding 0.720649395550746 bayes_pls_golite062009
nucleotide binding 0.717697610309727 bayes_pls_golite062009
purine ribonucleotide binding 0.713814218071151 bayes_pls_golite062009
ribonucleotide binding 0.713752628021599 bayes_pls_golite062009
transcription factor activity 0.603758349693077 bayes_pls_golite062009
ATP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
double-stranded DNA binding 0.58862275163252 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
structural constituent of ribosome 0.396187998943318 bayes_pls_golite062009
microtubule motor activity 0.38363601832205 bayes_pls_golite062009
guanyl nucleotide binding 0.296406132096546 bayes_pls_golite062009
GTP binding 0.295705904888768 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
guanyl ribonucleotide binding 0.29028316917561 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.22150712609541 bayes_pls_golite062009
ATP binding 0.19169045543599 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
adenyl ribonucleotide binding 0.165732470448462 bayes_pls_golite062009
adenyl nucleotide binding 0.162060759063149 bayes_pls_golite062009
substrate-specific transporter activity 0.144154288308693 bayes_pls_golite062009
active transmembrane transporter activity 0.114463153989353 bayes_pls_golite062009
motor activity 0.0492172159259601 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [255-438]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPLLGKFLRP HQREGVKFMY DCLMGLARPT IENPDIDCTT KSLVLENDSD ISGCLLADDM  60
   61 GLGKTLMSIT LIWTLIRQTP FASKVSCSQS GIPLTGLCKK ILVVCPVTLI GNWKREFGKW 120
  121 LNLSRIGVLT LSSRNSPDMD KMAVRNFLKV QRTYQVLIIG YEKLLSVSEE LEKNKHLIDM 180
  181 LVCD

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 4.721246
Match: PF00176.10
Description: No description for PF00176.10 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [439-924]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGHRLKNGAS KILNTLKSLD IRRKLLLTGT PIQNDLNEFF TIIDFINPGI LGSFASFKRR  60
   61 FIIPITRARD TANRYNEELL EKGEERSKEM IEITKRFILR RTNAILEKYL PPKTDIILFC 120
  121 KPYSQQILAF KDILQGARLD FGQLTFSSSL GLITLLKKVC NSPGLVGSDP YYKSHIKDTQ 180
  181 SQDSYSRSLN SGKLKVLMTL LEGIRKGTKE KVVVVSNYTQ TLDIIENLMN MAGMSHCRLD 240
  241 GSIPAKQRDS IVTSFNRNPA IFGFLLSAKS GGVGLNLVGR SRLILFDNDW NPSVDLQAMS 300
  301 RIHRDGQKKP CFIYRLVTTG CIDEKILQRQ LMKNSLSQKF LGDSEMRNKE SSNDDLFNKE 360
  361 DLKDLFSVHT DTKSNTHDLI CSCDGLGEEI EYPETNQQQN TVELRKRSTT TWTSALDLQK 420
  421 KMNEAATNDD AKKSQYIRQC LVHYKHIDPA RQDELFDEVI TDSFTELKDS ITFAFVKPGE 480
  481 ICLREQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.522879
Match: 1oyyA_
Description: Structure of the RecQ Catalytic Core bound to ATP-gamma-S
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle