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View Structure Prediction Details

Protein: MCM4
Organism: Saccharomyces cerevisiae
Length: 933 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCM4.

Description E-value Query
Range		 Subject
Range
MCM4_YEAST - DNA replication licensing factor MCM4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MC...
MCM4 - Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexe...
gi|151942808 - gi|151942808|gb|EDN61154.1| cell division cycle-related protein [Saccharomyces cerevisiae YJM789]
 0.0 [1..933] [1..933]
gi|940536, gi|10... - gi|940536|emb|CAA52801.1| P1 Cdc21 protein [Homo sapiens], gi|1098112|prf||2115257A Cdc21-like prote...
 0.0 [2..924] [28..921]
MCM4B_XENLA - DNA replication licensing factor mcm4-B OS=Xenopus laevis GN=mcm4-b PE=1 SV=3
 0.0 [21..924] [2..861]
MCM4_MOUSE - DNA replication licensing factor MCM4 OS=Mus musculus GN=Mcm4 PE=1 SV=1
 0.0 [21..924] [2..860]

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Predicted Domain #1
Region A:
Residues: [1-181] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQQSSSPTK EDNNSSSPVV PNPDSVPPQL SSPALFYSSS SSQGDIYGRN NSQNLSQGEG  60
   61 NIRAAIGSSP LNFPSSSQRQ NSDVFQSQGR QGRIRSSASA SGRSRYHSDL RSDRALPTSS 120
  121 SSLGRNGQNR VHMRRNDIHT SDLSSPRRIV DFDTRSGVNT LDTSSSSAPP SEASEPLRII 180
  181 W

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [182-306] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTNVSIQECT TNFRNFLMSF KYKFRKILDE REEFINNTTD EELYYIKQLN EMRELGTSNL  60
   61 NLDARNLLAY KQTEDLYHQL LNYPQEVISI MDQTIKDCMV SLIVDNNLDY DLDEIETKFY 120
  121 KVRPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 176.9691
Match: 1ltlA_
Description: DNA replication initiator (cdc21/cdc54) N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [307-340] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVGSCKGMRE LNPNDIDKLI NLKGLVLRST PVIP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [393-526] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKQVIKLQET PDFVPDGQTP HSISLCVYDE LVDSCRAGDR IEVTGTFRSI PIRANSRQRV  60
   61 LKSLYKTYVD VVHVKKVSDK RLDVDTSTIE QELMQNKVDH NEVEEVRQIT DQDLAKIREV 120
  121 AAREDLYSLL ARSI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 176.9691
Match: 1ltlA_
Description: DNA replication initiator (cdc21/cdc54) N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telomeric DNA binding 4.81350293592083 bayes_pls_golite062009
telomerase inhibitor activity 4.48082903165152 bayes_pls_golite062009
single-stranded telomeric DNA binding 4.34033743483519 bayes_pls_golite062009
nucleic acid binding 4.29626483284963 bayes_pls_golite062009
DNA binding 3.71771169141041 bayes_pls_golite062009
structural constituent of ribosome 3.51998515668903 bayes_pls_golite062009
structural molecule activity 3.29857127235306 bayes_pls_golite062009
structure-specific DNA binding 3.06066809614422 bayes_pls_golite062009
single-stranded DNA binding 3.0183551365402 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
transcription regulator activity 2.10110937001387 bayes_pls_golite062009
sequence-specific DNA binding 1.9581702424972 bayes_pls_golite062009
DNA replication origin binding 1.84819558112187 bayes_pls_golite062009
translation regulator activity 1.46320772716954 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.40718318783582 bayes_pls_golite062009
transcription repressor activity 1.30343463892105 bayes_pls_golite062009
translation initiation factor activity 1.27539679024898 bayes_pls_golite062009
transcription activator activity 1.24141936405635 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
DNA-directed RNA polymerase activity 1.19766815287926 bayes_pls_golite062009
RNA polymerase activity 1.19766815287926 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
transcription factor activity 1.14242112812892 bayes_pls_golite062009
DNA helicase activity 1.12203697857261 bayes_pls_golite062009
DNA-dependent ATPase activity 0.638831894247026 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.474251377131502 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.47336621289748 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.47336621289748 bayes_pls_golite062009
nucleotidyltransferase activity 0.325774164899685 bayes_pls_golite062009
four-way junction helicase activity 0.31769813397725 bayes_pls_golite062009
exonuclease activity 0.28313884527829 bayes_pls_golite062009
RNA binding 0.18502033889261 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.125256208482441 bayes_pls_golite062009
exoribonuclease activity 0.109774918833391 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.0954216620147701 bayes_pls_golite062009
DEAD/H-box RNA helicase binding 0.0627405398613412 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.0179535526984695 bayes_pls_golite062009
helicase activity 0.0121541775159524 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [341-392] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMKVAFFKCN VCDHTMAVEI DRGVIQEPAR CERIDCNEPN SMSLIHNRCS FA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 176.9691
Match: 1ltlA_
Description: DNA replication initiator (cdc21/cdc54) N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [527-755] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APSIYELEDV KKGILLQLFG GTNKTFTKGG RYRGDINILL CGDPSTSKSQ ILQYVHKITP  60
   61 RGVYTSGKGS SAVGLTAYIT RDVDTKQLVL ESGALVLSDG GVCCIDEFDK MSDSTRSVLH 120
  121 EVMEQQTISI AKAGIITTLN ARSSILASAN PIGSRYNPNL PVTENIDLPP PLLSRFDLVY 180
  181 LVLDKVDEKN DRELAKHLTN LYLEDKPEHI SQDDVLPVEF LTMYISYAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.0
Match: 1g8pA_
Description: ATPase subunit of magnesium chelatase, BchI
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [756-842] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHIHPIITEA AKTELVRAYV GMRKMGDDSR SDEKRITATT RQLESMIRLA EAHAKMKLKN  60
   61 VVELEDVQEA VRLIRSAIKD YATDPKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.0
Match: 1g8pA_
Description: ATPase subunit of magnesium chelatase, BchI
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [843-933] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKIDMNLVQT GKSVIQRKLQ EDLSREIMNV LKDQASDSMS FNELIKQINE HSQDRVESSD  60
   61 IQEALSRLQQ EDKVIVLGEG VRRSVRLNNR V

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.805 0.014 pre-replicative complex assembly d.68.3 SirA-like

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle