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View Structure Prediction Details

Protein: HRT1
Organism: Saccharomyces cerevisiae
Length: 121 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HRT1.

Description E-value Query
gi|4240031 - gi|4240031|dbj|BAA74802.1| DNA binding zinc finger protein (Pspzf) [Pisum sativum]
1.0E-23 [3..117] [364..467]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-23 [3..121] [280..388]
RBX1_YEAST - RING-box protein HRT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HRT1 PE=1 SV=1
HRT1 - RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gi...
gi|151945502 - gi|151945502|gb|EDN63743.1| Skp1-Cullin-F-box ubiquitin protein ligase (SCF) subunit [Saccharomyces ...
gi|190407219 - gi|190407219|gb|EDV10486.1| Skp1-Cullin-F-box ubiquitin protein ligase subunit [Saccharomyces cerevi...
6.0E-23 [1..121] [1..121]
MBR1_ARATH - E3 ubiquitin-protein ligase MBR1 OS=Arabidopsis thaliana GN=MBR1 PE=1 SV=1
3.0E-22 [3..113] [596..699]
gi|218187559 - gi|218187559|gb|EEC69986.1| hypothetical protein OsI_00495 [Oryza sativa Indica Group]
gi|50948809, gi|... - gi|9757680|dbj|BAB08199.1| unnamed protein product [Oryza sativa Japonica Group], gi|8570055|dbj|BAA...
3.0E-21 [3..112] [385..485]
gi|51980558 - gb|AAH82183.1| Unknown (protein for MGC:98645) [Xenopus laevis]
gi|90075658, gi|... - gi|90075658|dbj|BAE87509.1| unnamed protein product [Macaca fascicularis], gi|84579139|dbj|BAE73003....
gi|118082672 - gi|118082672|ref|XP_416239.2| PREDICTED: similar to RBX1 protein [Gallus gallus]
CCDS14009.1_1 - null
gi|114686557 - gi|114686557|ref|XP_515153.2| PREDICTED: similar to RBX1 protein isoform 5 [Pan troglodytes]
RBX1 - ring-box 1
gi|126338707 - gi|126338707|ref|XP_001363807.1| PREDICTED: similar to RBX1 protein [Monodelphis domestica]
RBX1_MOUSE - E3 ubiquitin-protein ligase RBX1 OS=Mus musculus GN=Rbx1 PE=1 SV=1
gi|76617022, gi|... - gi|88682859|gb|AAI05330.1| Ring-box 1 [Bos taurus], gi|76617022|ref|XP_597082.2| PREDICTED: similar ...
gi|109451460, gi... - gi|109452056|emb|CAK54890.1| RBX1 [synthetic construct], gi|109451460|emb|CAK54591.1| RBX1 [syntheti...
HGNC:9928|MIM:60... - 1
gi|72679391, gi|... - gi|77628004|ref|NP_001029307.1| ring-box 1 [Rattus norvegicus], gi|72679391|gb|AAI00259.1| Ring-box ...
tr|M3X867|M3X867... - Ring-box 1 OS=Felis catus GN=RBX1 PE=4 SV=1
gi|197127417 - gi|197127417|gb|ACH43915.1| putative RBX1 protein [Taeniopygia guttata]
gi|149743062 - gi|149743062|ref|XP_001502369.1| PREDICTED: similar to RING-box protein 1 (Rbx1) (Regulator of culli...
8.0E-21 [21..120] [8..107]
gi|19067884, gi|... - gi|62869880|gb|AAY18085.1| hyperosmotic protein 21 [Salmo salar], gi|62869878|gb|AAY18084.1| hyperos...
8.0E-21 [17..120] [83..188]
gi|12833653 - gi|12833653|dbj|BAB22612.1| unnamed protein product [Mus musculus]
2.0E-20 [21..120] [8..107]
gi|195347430, gi... - gi|195347430|ref|XP_002040256.1| GM19082 [Drosophila sechellia], gi|194121684|gb|EDW43727.1| GM19082...
FBpp0310165, Roc... - The gene Roc1a is referred to in FlyBase by the symbol Dmel\Roc1a (CG16982, FBgn0025638). It is a pr...
gi|195564465, gi... - gi|195564465|ref|XP_002105838.1| GD16520 [Drosophila simulans], gi|194203200|gb|EDX16776.1| GD16520 ...
gi|220952868 - gi|220952868|gb|ACL88977.1| Roc1a-PA [synthetic construct]
2.0E-20 [8..120] [1..107]


Predicted Domain #1
Region A:
Residues: [1-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
  121 R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 309.30103
Match: 1ldjB_
Description: RIGG-box protein 1 (RBX1) of SCF ubiquitin ligase complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 10.2497392096259 bayes_pls_golite062009
small conjugating protein ligase activity 10.0460587929138 bayes_pls_golite062009
acid-amino acid ligase activity 8.99384576623969 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 7.6988425139962 bayes_pls_golite062009
ligase activity 3.92677358871643 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
NEDD8 ligase activity 2.41658628840288 bayes_pls_golite062009
protein binding 1.5975811408548 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
transcription regulator activity 0.943706743211193 bayes_pls_golite062009
nucleic acid binding 0.708499177773075 bayes_pls_golite062009
hydrolase activity 0.52386813728704 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
DNA binding 0.365874679056682 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
transcription factor binding 0.16916169785605 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle