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View Structure Prediction Details

Protein: RRI2
Organism: Saccharomyces cerevisiae
Length: 645 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RRI2.

Description E-value Query
Range
Subject
Range
RRI2 - Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF...
CSN10_YEAST - COP9 signalosome complex subunit 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRI2...
0.0 [1..645] [1..645]

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Predicted Domain #1
Region A:
Residues: [1-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEDNNYDD FMLSDDEGME SIEMEEETDD EDKQNIEINE DNSQDDQDRG AARHKQHEQG  60
   61 TFEKHDRVED ICERIFEQGQ ALKEDERYKE ARDLFLKIYY KEEFSSDESI ERLMTWKFKS 120
  121 LIEILRLRAL QLYFQKNGAQ DLVLQILEDT ATMSVFLQRI DFQIDGNIFE LLSDTFEVLA 180
  181 PKWERVFLFD IEKVDRENMI CKIDFQKNFM DQFQWILRKP GKDCKLQNLQ RIIRKKIFIA 240
  241 VVWYQRLTMG NVFTPEISSQ IEILVKDNEC SSFEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [276-560]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNDLESVSML LQYYILEYMN TARINNRRLF KKCIDFFEML ISKSLTFSQE SGLMVILYTS  60
   61 KIVFILDSDS ENDLSFALMR YYDRKEELKN MFLYILKHLE EMGKLRERDI TSLFHKFILS 120
  121 GFIFTSMILE AISTDKINPF GFEQVKIALG SPIVNVLEDV YRCFAQLELR QLNASISLIP 180
  181 ELSVVLSGII QDIYYLAQTL KLWRKIARLY SCISISDIIS MLQISDDNEM TRDDLLTILM 240
  241 RSIMKNRSVV YFKLDLTSDL VYFGDENKVM LPRCSKEEFR LMISP

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.19
Match: 1qoyA
Description: Hemolysin E (HlyE, ClyA, SheA)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [561-645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDEETTEKAR LIDFEYVNDV AIYNNPTRIR TKSSKEFFNT LRKSRETVKL PRVSNQSNED  60
   61 TFLPSYMKFS NKYLELCKLA SNNLE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.544 b.36.1 PDZ domain-like
View Download 0.516 a.7.7 BAG domain
View Download 0.515 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.515 b.40.4 Nucleic acid-binding proteins
View Download 0.498 a.130.1 Chorismate mutase II
View Download 0.444 c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.439 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.434 a.61.1 Retroviral matrix proteins
View Download 0.427 d.74.2 C-terminal domain of arginine repressor
View Download 0.425 a.60.2 RuvA domain 2-like
View Download 0.425 b.55.1 PH domain-like
View Download 0.395 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.390 c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.386 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.384 d.189.1 PX domain
View Download 0.381 a.3.1 Cytochrome c
View Download 0.350 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.343 a.60.1 SAM/Pointed domain
View Download 0.320 b.31.1 EV matrix protein
View Download 0.313 d.189.1 PX domain
View Download 0.308 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.305 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.292 d.223.1 Polo domain
View Download 0.263 d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.254 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.251 d.203.1 DsrC, the gamma subunit of dissimilatory sulfite reductase
View Download 0.251 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.245 a.64.1 Saposin
View Download 0.245 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.244 a.29.4 RecG, N-terminal domain
View Download 0.239 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.237 a.2.5 Prefoldin
View Download 0.233 b.40.2 Bacterial enterotoxins
View Download 0.228 a.77.1 DEATH domain
View Download 0.225 a.7.6 Ribosomal protein S20
View Download 0.225 b.33.1 ISP domain
View Download 0.222 a.4.5 "Winged helix" DNA-binding domain
View Download 0.221 a.24.17 Group V grass pollen allergen
View Download 0.221 b.40.2 Bacterial enterotoxins
View Download 0.221 d.54.1 Enolase N-terminal domain-like
View Download 0.219 a.144.2 Ribosomal protein L20
View Download 0.216 d.15.7 Immunoglobulin-binding domains
View Download 0.203 a.4.7 Ribosomal protein L11, C-terminal domain
View Download 0.203 b.40.2 Bacterial enterotoxins
View Download 0.201 a.47.2 t-snare proteins

Predicted Domain #4
Region A:
Residues: [414-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFGFEQVKIA LGSPIVNVLE DVYRCFAQLE LRQLNASISL IPELSVVLSG IIQDIYYLAQ  60
   61 TLKLWRKIAR LYSCISISDI ISMLQISDDN EMTRDDLLTI LMRSIMKNRS VVYFKLDLTS 120
  121 DLVYFGDENK VMLPRCSKEE FRLMIS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.38
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.45730892915196 bayes_pls_golite062009
binding 3.37660003833383 bayes_pls_golite062009
DNA binding 3.14200456972385 bayes_pls_golite062009
nucleic acid binding 3.10521633426493 bayes_pls_golite062009
transcription factor activity 2.53044123488453 bayes_pls_golite062009
transcription repressor activity 2.13838000453063 bayes_pls_golite062009
small conjugating protein ligase activity 1.28416365596732 bayes_pls_golite062009
sequence-specific DNA binding 1.21263034180893 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.12766532785895 bayes_pls_golite062009
transcription activator activity 1.04520012516585 bayes_pls_golite062009
acid-amino acid ligase activity 0.761838897494019 bayes_pls_golite062009
protein binding 0.726445167461826 bayes_pls_golite062009
transcription factor binding 0.534573074451495 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.49516964123412 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.224432853777564 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [560-645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKDEETTEKA RLIDFEYVND VAIYNNPTRI RTKSSKEFFN TLRKSRETVK LPRVSNQSNE  60
   61 DTFLPSYMKF SNKYLELCKL ASNNLE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.544 b.36.1 PDZ domain-like
View Download 0.527 b.36.1 PDZ domain-like
View Download 0.516 a.7.7 BAG domain
View Download 0.515 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.515 b.40.4 Nucleic acid-binding proteins


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle