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View Structure Prediction Details

Protein: URK1
Organism: Saccharomyces cerevisiae
Length: 501 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for URK1.

Description E-value Query
Range
Subject
Range
UKL3_ARATH - Uridine kinase-like protein 3 OS=Arabidopsis thaliana GN=UKL3 PE=2 SV=1
0.0 [12..501] [3..464]
UCKL1_MOUSE - Uridine-cytidine kinase-like 1 OS=Mus musculus GN=Uckl1 PE=1 SV=1
0.0 [45..501] [87..533]
CE20700 - status:Confirmed UniProt:Q9U3I7 protein_id:CAA93462.1
0.0 [1..500] [41..543]
URK1_YEAST - Uridine kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URK1 PE=1 SV=1
URK1 - Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts ur...
0.0 [1..501] [1..501]

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Predicted Domain #1
Region A:
Residues: [1-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHRIAPSKE RSSSFISILD DETRDTLKAN AVMDGEVDVK KTKGKSSRYI PPWTTPYIIG  60
   61 IGGASGSGKT SVAAKIVSSI NVPWTVLISL DNFYNPLGPE DRARAFKNEY DFDEPNAINL 120
  121 DLAYKCILNL KEGKRTNIPV YSFVHHNRVP DKNIVIYGAS VVVIEGIYAL YDRRLLDLMD 180
  181 LKIYVDADLD VCLARRLSRD IVSRGRDLDG CIQQWEKFVK PNAVKFVKPT MKNADAIIPS 240
  241 MSDNATAVNL IINHIKSKLE LKSNEHLREL IKLGSSPSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.512579
Match: 1esmA_
Description: Pantothenate kinase PanK
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleobase, nucleoside, nucleotide kinase activity 3.66392587433723 bayes_pls_golite062009
binding 2.4974940028864 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.28726855139279 bayes_pls_golite062009
nucleotide kinase activity 2.24094813695083 bayes_pls_golite062009
pyrophosphatase activity 2.23754609668547 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.21702600128327 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.21503003850174 bayes_pls_golite062009
kinase activity 2.0779386406753 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 1.96697952975573 bayes_pls_golite062009
ATPase activity 1.70670922135201 bayes_pls_golite062009
hydrolase activity 1.20846280768115 bayes_pls_golite062009
nucleic acid binding 1.08697924060619 bayes_pls_golite062009
ATPase activity, coupled 1.02588328213159 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
GTPase activity 0.768815888267067 bayes_pls_golite062009
DNA binding 0.702147676354075 bayes_pls_golite062009
substrate-specific transporter activity 0.464456497491373 bayes_pls_golite062009
adenylate kinase activity 0.447752711852745 bayes_pls_golite062009
active transmembrane transporter activity 0.434775387083003 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
transporter activity 0.39890191703346 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
protein binding 0.378225828131122 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
primary active transmembrane transporter activity 0.294474570607914 bayes_pls_golite062009
transcription regulator activity 0.287777990975748 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.282352478532746 bayes_pls_golite062009
transmembrane transporter activity 0.22939561735194 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.220608508617331 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.219533217661421 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.219157471322311 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.0756212238097211 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [280-501]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVLNRNIIHE LPPTNQVLSL HTMLLNKNLN CADFVFYFDR LATILLSWAL DDIPVAHTNI  60
   61 ITPGEHTMEN VIACQFDQVT AVNIIRSGDC FMKSLRKTIP NITIGKLLIQ SDSQTGEPQL 120
  121 HCEFLPPNIE KFGKVFLMEG QIISGAAMIM AIQVLLDHGI DLEKISVVVY LATEVGIRRI 180
  181 LNAFDNKVNI FAGMIISREK LQNHQYKWAL TRFFDSKYFG CD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 255.383689
Match: 1bd3D_
Description: Uracil PRTase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
uracil phosphoribosyltransferase activity 3.97944228585882 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 3.91023158228049 bayes_pls_golite062009
adenine phosphoribosyltransferase activity 3.07502596276449 bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity 2.97347277288245 bayes_pls_golite062009
transferase activity 2.73727660668741 bayes_pls_golite062009
transferase activity, transferring pentosyl groups 2.53679639481311 bayes_pls_golite062009
catalytic activity 2.30431811394775 bayes_pls_golite062009
nucleobase binding 1.28671115202467 bayes_pls_golite062009
purine binding 1.24786927434743 bayes_pls_golite062009
binding 1.1364028086974 bayes_pls_golite062009
ribose phosphate diphosphokinase activity 0.947697983706416 bayes_pls_golite062009
diphosphotransferase activity 0.749909396904601 bayes_pls_golite062009
nucleic acid binding 0.552133387792911 bayes_pls_golite062009
DNA binding 0.439741935655503 bayes_pls_golite062009
transcription regulator activity 0.396538943915776 bayes_pls_golite062009
amidophosphoribosyltransferase activity 0.360901350940423 bayes_pls_golite062009
protein binding 0.182081394126725 bayes_pls_golite062009
orotate phosphoribosyltransferase activity 0.148898393751978 bayes_pls_golite062009

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