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View Structure Prediction Details

Protein: LIP2
Organism: Saccharomyces cerevisiae
Length: 328 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LIP2.

Description E-value Query
Range		 Subject
Range
LIPB_YEAST - Octanoyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LIP2 ...
LIP2 - Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic aci...
gi|151941075 - gi|151941075|gb|EDN59455.1| Lipoyl ligase [Saccharomyces cerevisiae YJM789]
gi|190405301 - gi|190405301|gb|EDV08568.1| lipoyl ligase [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..328] [1..328]
LIPB_KLULA - Octanoyltransferase, mitochondrial OS=Kluyveromyces lactis GN=LIPB PE=3 SV=1
LIPB_KLULA - Octanoyltransferase, mitochondrial OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 ...
 2.0E-99 [10..323] [19..329]
LIPB_BRUME - Octanoyltransferase OS=Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) GN=lipB ...
LIPB_BRUME - Octanoyltransferase OS=Brucella melitensis GN=lipB PE=3 SV=1
 3.0E-79 [27..314] [13..264]
LIP2P_ARATH - Plastidial lipoyltransferase 2 OS=Arabidopsis thaliana GN=LIP2p PE=2 SV=1
 1.0E-70 [80..324] [53..278]
LIPB_HAEIN - Octanoyltransferase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=lipB PE...
LIPB_HAEIN - Octanoyltransferase OS=Haemophilus influenzae GN=lipB PE=3 SV=2
 6.0E-67 [91..310] [15..207]
LIPB_RHIME - Octanoyltransferase OS=Rhizobium meliloti GN=lipB PE=3 SV=1
LIPB_RHIME - Octanoyltransferase OS=Rhizobium meliloti (strain 1021) GN=lipB PE=3 SV=1
 8.0E-67 [44..314] [18..250]
LIPB_PASMU - Octanoyltransferase OS=Pasteurella multocida GN=lipB PE=3 SV=1
LIPB_PASMU - Octanoyltransferase OS=Pasteurella multocida (strain Pm70) GN=lipB PE=3 SV=1
 8.0E-67 [79..310] [2..213]
LIPB_RHILO - Octanoyltransferase OS=Rhizobium loti GN=lipB PE=3 SV=1
LIPB_RHILO - Octanoyltransferase OS=Rhizobium loti (strain MAFF303099) GN=lipB PE=3 SV=1
 8.0E-67 [41..310] [2..234]
gi|25349504 - pir||D97548 lipoate-protein ligase b (lipoate biosynthesis protein b) [imported] - Agrobacterium tum...
LIPB_AGRFC - Octanoyltransferase OS=Agrobacterium fabrum (strain C58 / ATCC 33970) GN=lipB PE=3 SV=1
 3.0E-66 [55..311] [40..260]

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Predicted Domain #1
Region A:
Residues: [1-109] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRCIRQSVC TNFNVCRRQC FSTYASALKE MTHPIKPSAQ TLRHLQFTQR IPFQKGLEIQ  60
   61 ETLVRANLDI KDIQSKIERK LIQLDEEYKG TATINDNEKR ILDKVMAMK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [110-267] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNPIILTFEF EPTYTGGKRI KKTMTPDQIA AYESFIPETQ KDNPRPKFVQ VERGGQVTFH  60
   61 GPGQIVIYII LDLKTFQSFP AKCLVSCIEQ ATIRTLKNTK MCDDTDKPLN LDAMTTKDTG 120
  121 VWVENGKKKV ASVGIHVRRS ITSHGVAINV NTDLSYMN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 30.481486
Match: PF03099
Description: Biotin/lipoate A/B protein ligase family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
aminoacyl-tRNA ligase activity 4.83057889638134 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 4.8294067084702 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 4.8294067084702 bayes_pls_golite062009
ligase activity 3.51191116674556 bayes_pls_golite062009
catalytic activity 1.99372273395202 bayes_pls_golite062009
phenylalanine-tRNA ligase activity 1.57827239765705 bayes_pls_golite062009
serine-tRNA ligase activity 1.07048505740004 bayes_pls_golite062009
glycine-tRNA ligase activity 0.91005913703893 bayes_pls_golite062009
threonine-tRNA ligase activity 0.793195358470619 bayes_pls_golite062009
binding 0.521863822270226 bayes_pls_golite062009
alanine-tRNA ligase activity 0.435766663027965 bayes_pls_golite062009
histidine-tRNA ligase activity 0.334773354741163 bayes_pls_golite062009
lysine-tRNA ligase activity 0.333541891861949 bayes_pls_golite062009
nucleic acid binding 0.281662799812287 bayes_pls_golite062009
ATP binding 0.18403217430648 bayes_pls_golite062009
adenyl ribonucleotide binding 0.145955341735342 bayes_pls_golite062009
transcription regulator activity 0.134753238769136 bayes_pls_golite062009
adenyl nucleotide binding 0.127823774098159 bayes_pls_golite062009
DNA binding 0.0309732052586011 bayes_pls_golite062009
protein binding 0.0101455326199739 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [268-328] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFEMCGLKNT LTTSIMEQRP DAVVNVQSVA ISFVKEMTKL LGIKTLERMQ IDDVNILKKN  60
   61 P

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.860 0.820 ligase activity a.4.5 "Winged helix" DNA-binding domain

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle