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View Structure Prediction Details

Protein: PRP19
Organism: Saccharomyces cerevisiae
Length: 503 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP19.

Description E-value Query
Range
Subject
Range
gi|17225204 - gi|17225204|gb|AAL37298.1|AF323582_1 beta transducin-like protein HET-E2C [Podospora anserina]
0.0 [66..500] [850..1255]
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
0.0 [107..500] [1124..1488]
PRP19_MOUSE - Pre-mRNA-processing factor 19 OS=Mus musculus GN=Prpf19 PE=1 SV=1
PRP19_RAT - Pre-mRNA-processing factor 19 OS=Rattus norvegicus GN=Prpf19 PE=1 SV=2
2.0E-99 [1..493] [3..504]
PRPF19 - PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
gi|123990972, gi... - gi|123999345|gb|ABM87248.1| PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) [synthe...
gi|114637809 - gi|114637809|ref|XP_001142421.1| PREDICTED: PRP19/PSO4 pre-mRNA processing factor 19 homolog isoform...
CCDS7995.1_1 - null
HGNC:17896|MIM:6... - pre-mRNA processing factor 19 homolog (S. cerevisiae)
4.0E-99 [1..493] [3..504]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLCAISGKVP RRPVLSPKSR TIFEKSLLEQ YVKDTGNDPI TNEPLSIEEI VEIVPSAQQA  60
   61 SLTESTNSAT LKANYSIPNL LTSLQNEWDA IMLENFKLRS TLDSLTKKLS TVMYERDAAK 120
  121 LVAA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.69897
Match: 1bf5A_
Description: STAT-1, coiled coil domain; STAT-1, DNA-binding domain; STAT-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4.77196423114965 bayes_pls_golite062009
ubiquitin-protein ligase activity 3.95853381924066 bayes_pls_golite062009
small conjugating protein ligase activity 3.91255887330293 bayes_pls_golite062009
RNA binding 3.04658201081989 bayes_pls_golite062009
acid-amino acid ligase activity 2.94837447933806 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.32056863527247 bayes_pls_golite062009
nucleic acid binding 1.91926431269551 bayes_pls_golite062009
DNA binding 1.67694054164995 bayes_pls_golite062009
protein binding 1.5975811408548 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 1.43156142066182 bayes_pls_golite062009
ligase activity 1.36029325773279 bayes_pls_golite062009
transcription factor binding 1.04179360284548 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.97326424822508 bayes_pls_golite062009
transcription factor activity 0.942440775656356 bayes_pls_golite062009
hydrolase activity 0.39313698408945 bayes_pls_golite062009
transcription repressor activity 0.251823232412941 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription cofactor activity 0.120138679619734 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [125-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLLMEKNEDS KDLPKSSQQA VAITREEFLQ GLLQSSRDFV ARGKLKAPKW PILKNLELLQ  60
   61 AQNYSRNIKT FPYKELNKSM YYDKWVCMCR CEDGALHFTQ LKDSKTITTI TTPNPRTGGE 120
  121 HPAIISRGPC NRLLLLYPGN QITILDSKTN KVLREIEVDS ANEIIYMYGH NEVNTEYFIW 180
  181 ADNRGTIGFQ SYEDDSQYIV HSAKSDVEYS SGVLHKDSLL LALYSPDGIL DVYNLSSPDQ 240
  241 ASSRFPVDEE AKIKEVKFAD NGYWMVVECD QTVVCFDLRK DVGTLAYPTY TIPEFKTGTV 300
  301 TYDIDDSGKN MIAYSNESNS LTIYKFDKKT KNWTKDEESA LCLQSDTADF TDMDVVCGDG 360
  361 GIAAILKTND SFNIVALTP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.39794
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle