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View Structure Prediction Details

Protein: VTH2
Organism: Saccharomyces cerevisiae
Length: 1549 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VTH2.

Description E-value Query
Range
Subject
Range
VTH2 - Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in ...
VTH2_YEAST - VPS10 homolog 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VTH2 PE=1 SV=1
0.0 [1..1549] [1..1549]
VPS10_SCHPO - Vacuolar protein sorting/targeting protein 10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843)...
pep1 - sorting receptor for CPY
0.0 [7..1417] [14..1406]
gi|18032275 - gi|18032275|gb|AAL56667.1|AF284756_1 VPS10 domain receptor SorCS [Homo sapiens]
0.0 [717..1357] [193..795]
SORC1_MOUSE - VPS10 domain-containing receptor SorCS1 OS=Mus musculus GN=Sorcs1 PE=1 SV=1
0.0 [717..1357] [193..794]

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Predicted Domain #1
Region A:
Residues: [1-182]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALFRALYII WVFLLIPLSN AEEFTPKVTR TLSRYVFDIV NFDDSNTLIR AEEDSVEISF  60
   61 DAGENWKTID EIEEPIESFV VDPFRGHDRA FAFVKTAPKF YVTDDQGKSW RPLTIPISEK 120
  121 ASNYFCDVTT HPIKKKHLII RCDLLTIKNS GLMYVGREIY TTNDGVSFSQ VKPSFGKIDG 180
  181 HI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [183-536]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STARCDFIKS SEDSDLGGND ASILCLFRNT EYIESTGSTI DKSELILSAD GGETFKELVQ  60
   61 FKDKVVSRYE ILKHHVIVLT QDDMYNEMSS TNIWISNDVS TFQVARTPTK IRHVNMGQIH 120
  121 EDSIGRIVLP VSRERDDEDS NQPGAAEVLI SDSEGLKFLP INWIPNNQFG YINVAYPGFL 180
  181 KGTFFGSFHP FIEYSDRKRK YSRQKVREET KVSVDNGLTW TNLKVVDREN VDLFGCDVTK 240
  241 PERCSLQTHF YDLRNLNPSA GIMMISGIVG DGSAYNWKEE KTFISRDSGL TWRLVHNSTG 300
  301 LYTTGDLGNI IMYIPYRSNE NGDVPSKFYY SLDQGKTWGE YDLIMPIYPY RLVS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [537-722]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TISDGSGSKF ILTGTSITED PIFITYSIDF SAVFDYKSCE EGDFEDWNLA DGKCVNGAKY  60
   61 KYRRRKQDAQ CLVKKAFKDL SLDETPCNSC TGSDYECSFE FVRDAKGDCI PDYNLIALSD 120
  121 ICDKSKGKSV LVKPLQLIKG DKCKTPMKIE SVDIPCDEIP KEGSSDKEIV TTENKFDFEI 180
  181 KFYQYF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [723-1398]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTVADESLVM LNSIGDAYIS HDGGQTIKRF DTDGEKIVEI VFNPYFNSSA YLFGSKGNIF  60
   61 LTHDRGYSFM IAKLPEARQL GMPLDFSAKA QDTFIYYGGK NCESILSPEC HAVAYLTKDG 120
  121 GETFTEMLDN AIHCEFAGTL FKYPSNDDMV MCQVKEKFSQ TRSLVSSTDF FQDDRKTVFE 180
  181 NIIGYLSTGG YIIVAVPHED NELRAYVTND GAEFTEAKFP YDEDIGKQDA FTILGSEEGS 240
  241 IFLHLATNLE SGHDFGNLLK SNSNGTSFVT LEHAVNRNTF GYVDFEKVQG LEGIIITNIV 300
  301 SNSEKVGENK EDEQLKTKIT FNDGSDWNFL KPPKKDSEGK KFPCDSVSLD KCSLHLHGYT 360
  361 ERKDIRDTYS SGSALGMMFG VGNVGDRLLP YEECSTFLTT DGGETWTEVK KGPHQWEYGD 420
  421 HGGVLVLVPE NAETDSISYS TDFGKTWKDY KFCGDKVLVK DIITVPRDSA LRFLLFGEAK 480
  481 NMGSGSFRTY TIDFRNIFER QCEFDITGRK RADFKYSPLG SRTGCLFGHK TEFLRKTDEK 540
  541 CFIGNIPLSE FSRNVKNCPC TRQDFECDYN FYKASDGTCK LVKGLSSANG ADICKKEPDL 600
  601 IEYYDSSGYR KIPLSTCKGG LKLDAHLAPH PCPGKEKAFR EKYSINTGAY ALVFVTILLV 660
  661 IFFVAWFVYD RGIRRN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
hydrolase activity 1.41591334858024 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.31047753739918 bayes_pls_golite062009
binding 1.27390601147347 bayes_pls_golite062009
small conjugating protein ligase activity 1.24376651680335 bayes_pls_golite062009
transporter activity 1.10239137184953 bayes_pls_golite062009
transmembrane transporter activity 0.949536954960448 bayes_pls_golite062009
clathrin binding 0.86732360976983 bayes_pls_golite062009
substrate-specific transporter activity 0.781060752903079 bayes_pls_golite062009
peptidase activity 0.685308067211416 bayes_pls_golite062009
catalytic activity 0.660976915716016 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.660409340901077 bayes_pls_golite062009
ion transmembrane transporter activity 0.56446678342098 bayes_pls_golite062009
cation transmembrane transporter activity 0.486294295028555 bayes_pls_golite062009
channel activity 0.465630241372545 bayes_pls_golite062009
passive transmembrane transporter activity 0.465630241372545 bayes_pls_golite062009
substrate-specific channel activity 0.455589501590218 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.44519612509266 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.437060564683891 bayes_pls_golite062009
acid-amino acid ligase activity 0.423920288968837 bayes_pls_golite062009
potassium channel activity 0.423464159542763 bayes_pls_golite062009
cation channel activity 0.406614358442595 bayes_pls_golite062009
voltage-gated cation channel activity 0.402494949667906 bayes_pls_golite062009
voltage-gated ion channel activity 0.39571309893169 bayes_pls_golite062009
ion channel activity 0.395022246697853 bayes_pls_golite062009
voltage-gated channel activity 0.387394052239826 bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds 0.384942719946392 bayes_pls_golite062009
protein binding 0.358634999959382 bayes_pls_golite062009
voltage-gated potassium channel activity 0.326855275194847 bayes_pls_golite062009
ligand-gated channel activity 0.300015711462657 bayes_pls_golite062009
ligand-gated ion channel activity 0.300015711462657 bayes_pls_golite062009
gated channel activity 0.266124158878986 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 0.258360510712111 bayes_pls_golite062009
sugar binding 0.209524155254648 bayes_pls_golite062009
monosaccharide binding 0.165171466772385 bayes_pls_golite062009
cytoskeletal protein binding 0.0429267214247906 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1399-1549]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGFSRFEEIR LGDDGLIENN RTDRVVNIIV RLGLCISLIT KSAFQRAKAG TAQLSSKFRA  60
   61 RFGNKKGATY SSLLHDQLSD EPDGFHEDSN DLSSFRGQGS NSEIEQEDVD TSQQEHTSRT 120
  121 DLLGASNIPD ALPARSASHE SDLAAARSED K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle