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View Structure Prediction Details

Protein: UPF3
Organism: Saccharomyces cerevisiae
Length: 387 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UPF3.

Description E-value Query
Range
Subject
Range
UPF3_YEAST - Nonsense-mediated mRNA decay protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=U...
UPF3 - Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in...
0.0 [1..387] [1..387]
gi|25535937, gi|... - gi|7242963|dbj|BAA92542.1| KIAA1304 protein [Homo sapiens], pir||G59436 KIAA1304 protein [imported] ...
4.0E-61 [172..335] [99..245]
gi|27597098, gi|... - gi|27597098|ref|NP_536696.2| brain stress early protein Gbi isoform 1 [Mus musculus], gi|14028714|gb...
2.0E-55 [183..335] [8..144]
srgp-1 - chimaerin like status:Partially_confirmed UniProt:Q19370 protein_id:CAA97790.1
5.0E-35 [193..333] [161..276]

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Predicted Domain #1
Region A:
Residues: [1-60]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNVAGELKN SEGKKKGRGN RYHNKNRGKS KNETVDPKKN ENKVNNATNA THNNSKGRRN  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [61-280]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKKRNREYYN YKRKARLGKS TENEGFKLVI RLLPPNLTAD EFFAILRDNN NDDGDKQDIQ  60
   61 GKLKYSDWCF FEGHYSSKVF KNSTYSRCNF LFDNLSDLEK CANFIKTCKF IDNKDNITIP 120
  121 DMKLSPYVKK FTQTSKKDAA LVGTIEEDEI FKTFMNSMKQ LNENDEYSFQ DFSVLKSLEK 180
  181 EFSKSIELEN KIAERTERVL TELVGTGDKV KNKNKKKKNK 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 121.070581
Match: PF03467
Description: Smg-4/UPF3 family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
RNA binding 6.32219487559982 bayes_pls_golite062009
mRNA binding 4.87640532914983 bayes_pls_golite062009
3.85463717617256 bayes_pls_golite062009
nucleic acid binding 3.74344299117899 bayes_pls_golite062009
binding 2.88749864706998 bayes_pls_golite062009
single-stranded RNA binding 2.55628738360472 bayes_pls_golite062009
poly-pyrimidine tract binding 2.0656412663177 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.79747940153321 bayes_pls_golite062009
structural molecule activity 1.57342338925793 bayes_pls_golite062009
small conjugating protein ligase activity 1.54918359800898 bayes_pls_golite062009
poly(U) RNA binding 1.23190154914055 bayes_pls_golite062009
protein binding 1.19509385638328 bayes_pls_golite062009
transcription regulator activity 1.10029555513317 bayes_pls_golite062009
acid-amino acid ligase activity 1.0920515408093 bayes_pls_golite062009
DNA binding 0.984725930713243 bayes_pls_golite062009
snRNA binding 0.840923669704678 bayes_pls_golite062009
snoRNA binding 0.516511855622792 bayes_pls_golite062009
hydrolase activity 0.418157930682314 bayes_pls_golite062009
transcription factor activity 0.255891228964936 bayes_pls_golite062009
mRNA 3'-UTR binding 0.229644510503376 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.205114038263623 bayes_pls_golite062009
ligase activity 0.115699011007988 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [281-387]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAKKKFKEEE ASAKIPKKKR NRGKKKRENR EKSTISKTKN SNVVIIEEAG KEVLKQRKKK  60
   61 MLLQEKLKIS NSSQPQSSSA QTQPSFQPKE NLFVPRVKIL HRDDTKK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [303-387]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKKKRENREK STISKTKNSN VVIIEEAGKE VLKQRKKKML LQEKLKISNS SQPQSSSAQT  60
   61 QPSFQPKENL FVPRVKILHR DDTKK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle