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View Structure Prediction Details

Protein: RCK1
Organism: Saccharomyces cerevisiae
Length: 512 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RCK1.

Description E-value Query
Range		 Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [3..506] [6..457]
RCK1_YEAST - Serine/threonine-protein kinase RCK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RCK...
RCK1 - Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe ce...
 0.0 [1..512] [1..512]
gi|15289758 - gi|15289758|dbj|BAB63463.1| calcium dependent protein kinase [Solanum tuberosum]
 0.0 [3..506] [6..461]
gi|16215467 - gi|16215467|emb|CAC82998.1| calcium-dependent protein kinase 2 [Nicotiana tabacum]
 0.0 [3..506] [6..464]
gi|16215475 - gi|16215475|emb|CAC83000.1| calcium-dependent protein kinase 2 [Nicotiana benthamiana]
 0.0 [3..506] [6..464]
CDPKL_ARATH - Calcium-dependent protein kinase 21 OS=Arabidopsis thaliana GN=CPK21 PE=1 SV=1
 0.0 [49..506] [1..426]

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Predicted Domain #1
Region A:
Residues: [1-94] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVNPEFIAD GIDFYPTTPD AAYFNAADGK NKVNRINGNS ENLHHSFASG CRRSSLSVDF  60
   61 NVTSSDSEKS EQSCLENNSQ EDEYFCDIFS TELK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
telethonin binding 1.59285057739948 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
transporter activity 1.07717671444596 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
transmembrane transporter activity 0.93867354225509 bayes_pls_golite062009
sequence-specific DNA binding 0.925299895386908 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
alpha-actinin binding 0.713064190387634 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
substrate-specific transporter activity 0.419967454336647 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
kinase binding 0.26752427107238 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
ErbB-2 class receptor binding 0.182469382556979 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.176810368721201 bayes_pls_golite062009
insulin receptor binding 0.09784832072622 bayes_pls_golite062009
MAP kinase activity 0.08504542461349 bayes_pls_golite062009
protein kinase binding 0.00674998152095019 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [95-218] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDETSNKSTD YSSSNHQYPE QLELHNYKLL NKIGEGAFSR VFKAVGINTD DQAPVAIKAI  60
   61 IKKGISSDAI LKGNDRIQGS SRKKVLNEVA IHKLVSKNNP HCTKFIAFQE SANYYYLVTE 120
  121 LVTG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [442-457] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAETLHCALS CQSEKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 623.228787
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [219-441] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEIFDRIVQL TCFSEDLARH VITQVAIAIK HMHYMGIVHR DVKPENLLFE PIPFYGLDGD  60
   61 MQKEDEFTLG VGGGGIGLVK LMDFGLAKKL RNNTAKTPCG TIEYVASEVF TSKRYSMKVD 120
  121 MWSIGCVLFT LLCGYPPFYE KNEKTLLKKI SRGDYEFLAP WWDNISSGAK NAVTHLLEVD 180
  181 PNKRYDIDDF LNDPWLNSYD CLKDSNSNSY ASVQSILNDS FDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 623.228787
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [458-512] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDTEFSRSES SEYIFMTEED RNLRGSWIGE PKECFTLDLA TSSIYRRRKN KIFFW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.154902
Match: 1lj6A_
Description: No description for 1lj6A_ was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle