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View Structure Prediction Details

Protein: RSC8
Organism: Saccharomyces cerevisiae
Length: 557 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RSC8.

Description E-value Query
Range
Subject
Range
RSC8 - Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homol...
RSC8_YEAST - Chromatin structure-remodeling complex protein RSC8 OS=Saccharomyces cerevisiae (strain ATCC 204508 ...
0.0 [1..557] [1..557]
ssr2 - SWI /SNF and RSC complex subunit Ssr2
SSR2_SCHPO - SWI/SNF and RSC complexes subunit ssr2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ssr...
0.0 [66..488] [4..451]
gi|32880191, gi|... - gi|32880191|gb|AAP88926.1| SWI/SNF related, matrix associated, actin dependent regulator of chromati...
gi|60654775 - gi|60654775|gb|AAX31952.1| SWI/SNF related matrix associated actin-dependent regulator of chromatin ...
0.0 [2..438] [337..759]
mor-PA - The gene moira is referred to in FlyBase by the symbol Dmel\mor (CG18740, FBgn0002783). It is a prot...
7.0E-87 [2..397] [342..742]
SWI3D_ARATH - SWI/SNF complex subunit SWI3D OS=Arabidopsis thaliana GN=SWI3D PE=1 SV=3
2.0E-85 [9..463] [62..506]
gi|6678027, gi|1... - pir||T30967 transcription activator SRG3 - mouse, gi|6678027|ref|NP_033237.1| SWI/SNF related, matr...
2.0E-73 [2..254] [362..619]

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Predicted Domain #1
Region A:
Residues: [1-177]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDTEKDKDV PMVDSHEATE EPPTTSTNTP SFPHLAQEQA KEESATLGAE VAHKKINYEQ  60
   61 EAQKLEEKAL RFLAKQTHPV IIPSFASWFD ISKIHEIEKR SNPDFFNDSS RFKTPKAYKD 120
  121 TRNFIINTYR LSPYEYLTIT AVRRNVAMDV ASIVKIHAFL EKWGLINYQI DPRTKPS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [178-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIGPSFTGHF QVVLDTPQGL KPFLPENVIK QEVEGGDGAE PQVKKEFPVN LTIKKNVYDS  60
   61 AQDFNALQDE 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.561 a.65.1 Annexin
View Download 0.543 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.503 a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.453 a.4.12 TrpR-like
View Download 0.339 a.4.1 Homeodomain-like
View Download 0.306 a.4.5 "Winged helix" DNA-binding domain
View Download 0.291 d.50.3 PI-Pfui intein middle domain
View Download 0.288 a.50.1 Anaphylotoxins (complement system)
View Download 0.238 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.232 a.4.1 Homeodomain-like
View Download 0.223 a.77.1 DEATH domain
View Download 0.211 a.4.5 "Winged helix" DNA-binding domain
View Download 0.206 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like

Predicted Domain #3
Region A:
Residues: [248-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRNSRQIHKV YICHTCGNES INVRYHNLRA RDTNLCSRCF QEGHFGANFQ SSDFIRL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 21.853872
Match: PF00569
Description: Zinc finger, ZZ type

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
small conjugating protein ligase activity 2.40569731991064 bayes_pls_golite062009
nucleic acid binding 2.32387297115017 bayes_pls_golite062009
ligase activity 2.30828657077565 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.29312770004164 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.11206038007886 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
protein binding 1.5975811408548 bayes_pls_golite062009
acid-amino acid ligase activity 1.3853719864144 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.90321253993065 bayes_pls_golite062009
transcription repressor activity 0.350170315296021 bayes_pls_golite062009
transcription coactivator activity 0.255669498391574 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription activator activity 0.126093965701234 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.024993043379745 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [305-358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENNGNSVKKN WSDQEMLLLL EGIEMYEDQW EKIADHVGGH KRVEDCIEKF LSLP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.30103
Match: 1h8aC_
Description: v-Myb
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [359-431]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEDNYIREVV GSTLNGKGGD SRDGSVSGSK LMECVNDAVQ TLLQGDDKLG KVSDKSREIS  60
   61 EKYIEESQAI IQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1dg3A_
Description: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [432-557]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVKLTMEKLE SKFTKLCDLE TQLEMEKLKY VKESEKMLND RLSLSKQILD LNKSLEELNV  60
   61 SKKLVLISEQ VDSGIQLVEK DQEGDDEDGN TATGHGVKRV GKEGEEVGEG DSIAKLQPQV 120
  121 YKPWSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1dg3A_
Description: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle