| Protein: | ISW1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 1129 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISW1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1129] | [1..1129] |
|
|
0.0 | [4..1129] | [18..1143] |
|
|
0.0 | [56..1097] | [49..1050] |
|
|
0.0 | [35..1097] | [4..1045] |
|
|
0.0 | [92..1057] | [30..967] |
|
|
0.0 | [21..1091] | [74..1096] |
|
|
0.0 | [2..973] | [510..1519] |
|
Region A: Residues: [1-122] |
1 11 21 31 41 51
| | | | | |
1 MAYMLAIANF HFFKFYTRMR KKHENNSCNE KDKDENLFKI ILAIFLQEKK KYDCISSGSI 60
61 MTASEEYLEN LKPFQVGLPP HDPESNKKRY LLKDANGKKF DLEGTTKRFE HLLSLSGLFK 120
121 HF
|
| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.517 | 0.125 | chromatin remodeling | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.713 | 0.018 | chromatin remodeling | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.821 | 0.016 | chromatin remodeling | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.658 | 0.013 | chromatin remodeling | a.24.4 | Hemerythrin |
| View | Download | 0.531 | 0.003 | chromatin remodeling | g.36.1 | Ferredoxin thioredoxin reductase (FTR), catalytic beta chain |
| View | Download | 0.821 | N/A | N/A | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.713 | N/A | N/A | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.658 | N/A | N/A | a.24.4 | Hemerythrin |
| View | Download | 0.531 | N/A | N/A | g.36.1 | Ferredoxin thioredoxin reductase (FTR), catalytic beta chain |
| View | Download | 0.517 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.484 | N/A | N/A | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.467 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.464 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.457 | N/A | N/A | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.442 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.424 | N/A | N/A | f.36.1 | Neurotransmitter-gated ion-channel pransmembrane pore |
| View | Download | 0.404 | N/A | N/A | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.392 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.386 | N/A | N/A | a.142.1 | PTS-regulatory domain, PRD |
| View | Download | 0.377 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.362 | N/A | N/A | a.40.1 | Calponin-homology domain, CH-domain |
| View | Download | 0.352 | N/A | N/A | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.349 | N/A | N/A | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.340 | N/A | N/A | c.51.2 | TolB, N-terminal domain |
| View | Download | 0.339 | N/A | N/A | a.19.1 | Fertilization protein |
| View | Download | 0.338 | N/A | N/A | a.7.7 | BAG domain |
| View | Download | 0.323 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.318 | N/A | N/A | a.4.1 | Homeodomain-like |
| View | Download | 0.311 | N/A | N/A | a.22.1 | Histone-fold |
| View | Download | 0.310 | N/A | N/A | c.53.1 | Resolvase-like |
| View | Download | 0.303 | N/A | N/A | a.48.1 | N-terminal domain of cbl (N-cbl) |
| View | Download | 0.302 | N/A | N/A | a.73.1 | Retrovirus capsid protein, N-terminal core domain |
| View | Download | 0.293 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.285 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.278 | N/A | N/A | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.255 | N/A | N/A | a.29.3 | Acyl-CoA dehydrogenase C-terminal domain-like |
| View | Download | 0.251 | N/A | N/A | a.71.2 | Helical domain of Sec23/24 |
| View | Download | 0.248 | N/A | N/A | a.63.1 | Apolipophorin-III |
| View | Download | 0.246 | N/A | N/A | a.185.1 | Gametocyte protein Pfg27 |
| View | Download | 0.245 | N/A | N/A | a.55.1 | IHF-like DNA-binding proteins |
| View | Download | 0.243 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.238 | N/A | N/A | b.55.1 | PH domain-like |
| View | Download | 0.237 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.235 | N/A | N/A | a.142.1 | PTS-regulatory domain, PRD |
| View | Download | 0.228 | N/A | N/A | a.24.2 | Aspartate receptor, ligand-binding domain |
| View | Download | 0.227 | N/A | N/A | d.58.1 | 4Fe-4S ferredoxins |
| View | Download | 0.221 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.216 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.211 | N/A | N/A | a.60.6 | DNA polymerase beta, N-terminal domain-like |
| View | Download | 0.206 | N/A | N/A | a.126.1 | Serum albumin-like |
| View | Download | 0.204 | N/A | N/A | f.18.1 | F1F0 ATP synthase subunit A |
|
Region A: Residues: [123-375] |
1 11 21 31 41 51
| | | | | |
1 IESKAAKDPK FRQVLDVLEE NKANGKGKGK HQDVRRRKTE HEEDAELLKE EDSDDDESIE 60
61 FQFRESPAYV NGQLRPYQIQ GVNWLVSLHK NKIAGILADE MGLGKTLQTI SFLGYLRYIE 120
121 KIPGPFLVIA PKSTLNNWLR EINRWTPDVN AFILQGDKEE RAELIQKKLL GCDFDVVIAS 180
181 YEIIIREKSP LKKINWEYII IDEAHRIKNE ESMLSQVLRE FTSRNRLLIT GTPLQNNLHE 240
241 LWALLNFLLP DIF
|
| Detection Method: | |
| Confidence: | 4.69897 |
| Match: | 1gm5A_ |
| Description: | RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| general RNA polymerase II transcription factor activity | 3.1726526166851 | bayes_pls_golite062009 |
| binding | 2.64537357529343 | bayes_pls_golite062009 |
| nucleic acid binding | 2.51683451033161 | bayes_pls_golite062009 |
| DNA binding | 2.12258000781149 | bayes_pls_golite062009 |
| transcription regulator activity | 2.09345198747025 | bayes_pls_golite062009 |
| structural constituent of ribosome | 1.47858140861683 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 1.23094623498843 | bayes_pls_golite062009 |
| protein binding | 1.22129154759482 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.21658213854831 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.21652144153182 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.21571071905795 | bayes_pls_golite062009 |
| nucleotide binding | 1.20347573865566 | bayes_pls_golite062009 |
| motor activity | 1.14667913749579 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 1.11383295816593 | bayes_pls_golite062009 |
| lysine N-acetyltransferase activity | 1.05990253628867 | bayes_pls_golite062009 |
| histone acetyltransferase activity | 1.05990253628867 | bayes_pls_golite062009 |
| catalytic activity | 1.00104173493322 | bayes_pls_golite062009 |
| transcription activator activity | 0.889929694023098 | bayes_pls_golite062009 |
| transcription factor activity | 0.887108427603557 | bayes_pls_golite062009 |
| structural molecule activity | 0.86514677273731 | bayes_pls_golite062009 |
| transcription repressor activity | 0.862685397469217 | bayes_pls_golite062009 |
| protein-DNA loading ATPase activity | 0.729056749897011 | bayes_pls_golite062009 |
| steroid hormone receptor binding | 0.647625526012423 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.620212706423176 | bayes_pls_golite062009 |
| helicase activity | 0.6191010101321 | bayes_pls_golite062009 |
| microtubule motor activity | 0.60036517876321 | bayes_pls_golite062009 |
| DNA helicase activity | 0.57378485697982 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.543891899378373 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.500462538667228 | bayes_pls_golite062009 |
| DNA clamp loader activity | 0.49811753387851 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.49000746592281 | bayes_pls_golite062009 |
| guanyl nucleotide binding | 0.388587892299301 | bayes_pls_golite062009 |
| guanyl ribonucleotide binding | 0.372638007722845 | bayes_pls_golite062009 |
| GTP binding | 0.364508542344128 | bayes_pls_golite062009 |
| hormone receptor binding | 0.351501100511918 | bayes_pls_golite062009 |
| centromeric DNA binding | 0.322818640526369 | bayes_pls_golite062009 |
| ATP-dependent helicase activity | 0.29664013896754 | bayes_pls_golite062009 |
| purine NTP-dependent helicase activity | 0.29664013896754 | bayes_pls_golite062009 |
| translation regulator activity | 0.29096092258568 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 0.274994961137851 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 0.24825301806267 | bayes_pls_golite062009 |
| nuclear hormone receptor binding | 0.246160342138071 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.243902356228423 | bayes_pls_golite062009 |
| GTPase activity | 0.234351968078991 | bayes_pls_golite062009 |
| ATP binding | 0.1860481660648 | bayes_pls_golite062009 |
| RNA helicase activity | 0.18426050934025 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 0.152859582615242 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.147579541298736 | bayes_pls_golite062009 |
| RNA-dependent ATPase activity | 0.14606996093053 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 0.138615225841109 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.133017653323467 | bayes_pls_golite062009 |
| ATP-dependent RNA helicase activity | 0.13050483816765 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.113504049290503 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.111293884322157 | bayes_pls_golite062009 |
| actin binding | 0.00482938540552702 | bayes_pls_golite062009 |
|
Region A: Residues: [376-433] |
1 11 21 31 41 51
| | | | | |
1 SDAQDFDDWF SSESTEEDQD KIVKQLHTVL QPFLLRRIKS DVETSLLPKK ELNLYVGM
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.397 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.714 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.490 | f.13.1 | Family A G protein-coupled receptor-like |
| View | Download | 0.493 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.394 | a.56.1 | CO dehydrogenase ISP C-domain like |
| View | Download | 0.387 | a.60.1 | SAM/Pointed domain |
| View | Download | 0.368 | a.46.2 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| View | Download | 0.365 | d.15.2 | CAD & PB1 domains |
| View | Download | 0.361 | f.30.1 | Photosystem I reaction center subunit X, PsaK |
| View | Download | 0.357 | a.60.12 | DNA polymerase beta-like, second domain |
| View | Download | 0.354 | a.50.1 | Anaphylotoxins (complement system) |
| View | Download | 0.354 | a.179.1 | Replisome organizer (g39p helicase loader/inhibitor protein) |
| View | Download | 0.351 | a.22.1 | Histone-fold |
| View | Download | 0.335 | a.23.5 | Hemolysin expression modulating protein HHA |
| View | Download | 0.330 | a.144.2 | Ribosomal protein L20 |
| View | Download | 0.320 | a.179.1 | Replisome organizer (g39p helicase loader/inhibitor protein) |
| View | Download | 0.306 | a.4.1 | Homeodomain-like |
| View | Download | 0.305 | a.5.1 | DNA helicase RuvA subunit, C-terminal domain |
| View | Download | 0.287 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.285 | a.164.1 | C-terminal domain of DFF45/ICAD (DFF-C domain) |
| View | Download | 0.272 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.261 | a.5.2 | UBA-like |
| View | Download | 0.252 | a.48.3 | Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 |
| View | Download | 0.251 | a.179.1 | Replisome organizer (g39p helicase loader/inhibitor protein) |
| View | Download | 0.242 | a.76.1 | Iron-dependent represor protein, dimerization domain |
| View | Download | 0.241 | d.52.7 | Ribosome-binding factor A, RbfA |
| View | Download | 0.238 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.235 | a.180.1 | N-terminal, cytoplasmic domain of anti-sigmaE factor RseA |
| View | Download | 0.235 | a.5.1 | DNA helicase RuvA subunit, C-terminal domain |
| View | Download | 0.230 | a.60.13 | Putative methyltransferase TM0872, insert domain |
| View | Download | 0.230 | a.101.1 | Uteroglobin-like |
| View | Download | 0.226 | a.65.1 | Annexin |
| View | Download | 0.224 | a.5.2 | UBA-like |
| View | Download | 0.224 | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.222 | a.4.1 | Homeodomain-like |
| View | Download | 0.221 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.220 | a.28.3 | Retrovirus capsid protein C-terminal domain |
| View | Download | 0.220 | a.2.7 | tRNA-binding arm |
| View | Download | 0.214 | a.35.1 | lambda repressor-like DNA-binding domains |
| View | Download | 0.210 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.208 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
|
Region A: Residues: [434-618] |
1 11 21 31 41 51
| | | | | |
1 SSMQKKWYKK ILEKDLDAVN GSNGSKESKT RLLNIMMQLR KCCNHPYLFD GAEPGPPYTT 60
61 DEHLVYNAAK LQVLDKLLKK LKEEGSRVLI FSQMSRLLDI LEDYCYFRNY EYCRIDGSTA 120
121 HEDRIQAIDD YNAPDSKKFV FLLTTRAGGL GINLTSADVV VLYDSDWNPQ ADLQAMDRAH 180
181 RIGQK
|
| Detection Method: | |
| Confidence: | 11.154902 |
| Match: | 1hv8A_ |
| Description: | Putative DEAD box RNA helicase |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [619-990] |
1 11 21 31 41 51
| | | | | |
1 KQVKVFRLVT DNSVEEKILE RATQKLRLDQ LVIQQNRTSL KKKENKADSK DALLSMIQHG 60
61 AADVFKSGTS TGSAGTPEPG SGEKGDDIDL DELLLKSENK TKSLNAKYET LGLDDLQKFN 120
121 QDSAYEWNGQ DFKKKIQRDI ISPLLLNPTK RERKENYSID NYYKDVLNTG RSSTPSHPRM 180
181 PKPHVFHSHQ LQPPQLKVLY EKERMWTAKK TGYVPTMDDV KAAYGDISDE EEKKQKLELL 240
241 KLSVNNSQPL TEEEEKMKAD WESEGFTNWN KLEFRKFITV SGKYGRNSIQ AIARELAPGK 300
301 TLEEVRAYAK AFWSNIERIE DYEKYLKIIE NEEEKIKRVK MQQEALRRKL SEYKNPFFDL 360
361 KLKHPPSSNN KR
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [991-1129] |
1 11 21 31 41 51
| | | | | |
1 TYSEEEDRFI LLMLFKYGLD RDDVYELVRD EIRDCPLFEL DFYFRSRTPV ELARRGNTLL 60
61 QCLEKEFNAG IVLDDATKDR MKKEDENGKR IREEFADQTA NEKENVDGVE SKKAKIEDTS 120
121 NVGTEQLVAE KIPENETTH
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.291 | d.20.1 | UBC-like |
| View | Download | 0.259 | a.77.1 | DEATH domain |
| View | Download | 0.270 | a.118.8 | TPR-like |
| View | Download | 0.273 | a.74.1 | Cyclin-like |
| View | Download | 0.261 | a.174.1 | Double Clp-N motif |
| View | Download | 0.232 | d.162.1 | LDH C-terminal domain-like |
| View | Download | 0.212 | d.58.13 | Anticodon-binding domain of PheRS |
| View | Download | 0.207 | a.74.1 | Cyclin-like |
